Palytoxin down-modulates the epidermal growth factor receptor through a sodium-dependent pathway

Early Signals in the Mitogenic Response

1986 • 1,498 citations

Amiloride: a molecular probe of sodium transport in tissues and cells

1982 • 837 citations

Epidermal growth factor. Relationship between receptor regulation and mitogenesis in 3T3 cells.

1978 • 324 citations

Structure of palytoxin

1981 • 263 citations

An Integrated view of the Molecular Toxinology of Sodium Channel Gating in Excitable Cells

1987 • 221 citations

Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor.

1984 • 219 citations

Further studies on palytoxin. II. structure of palytoxin

1981 • 176 citations

Lys-bradykinin stimulates Na+ influx and DNA synthesis in cultured human fibroblasts

1983 • 127 citations

A transient rise in cytosolic calcium follows stimulation of quiescent cells with growth factors and is inhibitable with phorbol myristate acetate.

1985 • 121 citations

Inhibition of chemotactic factor-activated Na+/H+ exchange in human neutrophils by analogues of amiloride: structure-activity relationships in the amiloride series.

1986 • 113 citations

Ouabain inhibits the increase due to palytoxin of cation permeability of erythrocytes

1982 • 109 citations

Palytoxin is a non-12-O-tetradecanoylphorbol-13-acetate type tumor promoter in two-stage mouse skin carcinogenesis

1986 • 103 citations

Activation of 45Ca2+ influx and 22Na+/H+ exchange by epidermal growth factor and vanadate in A431 cells is independent of phosphatidylinositol turnover and is inhibited by phorbol ester and diacylglycerol.

1986 • 101 citations

Platelet-derived growth factor modulates epidermal growth factor receptors by a mechanism distinct from that of phorbol esters.

1986 • 76 citations

Inhibition of epidermal growth factor-induced mitogenesis by amiloride and an analog: evidence against a requirement for Na+/H+ exchange.

1984 • 74 citations

Tetrodotoxin-sensitive sodium channels in normal human fibroblasts and normal human glia-like cells.

1979 • 68 citations

Ion selectivity of epithelial Na channels

1987 • 58 citations

The mode of contractile action of palytoxin on vascular smooth muscle

1977 • 58 citations

Cytosolic calcium regulates epidermal growth factor endocytosis in rat pancreas and cultured fibroblasts.

1984 • 46 citations

Involvement of (Na+ + K+)-ATPase in binding and actions of palytoxin on human erythrocytes

1986 • 45 citations

Palytoxin isolated from marine coelenterates. The inhibitory action on (Na,K)-ATPase.

1983 • 44 citations

Aequorin entrapment in mammalian cells

1985 • 38 citations

Molecular Basis of the Permeabilization of Mammalian Cells by Ionophores

1982 • 37 citations

Palytoxin binds to and inhibits kidney and erythrocyte Na+, K+-ATPase

1984 • 37 citations

Interaction of palytoxin and cardiac glycosides on erythrocyte membrane and (Na+ + K+) ATPase

1985 • 36 citations

Heterologous regulation of the epidermal growth factor receptor by palytoxin, a non-12-O-tetradecanoylphorbol-13-acetate-type tumor promoter.

1987 • 34 citations

Mechanism of palytoxin-induced [3H]norepinephrine release from a rat pheochromocytoma cell line.

1984 • 32 citations

The β2-adrenergic receptors of human epidermoid carcinoma cells bear two different types of oligosaccharides which influence expression on the cell surface

1988 • 31 citations

Involvement of (Na+ + K+)-ATPase in binding and actions of palytoxin on human erythrocytes

1986 • 25 citations

Growth factors modify the epidermal growth factor receptor through multiple pathways

1987 • 24 citations

Evaluation of surface tension and ion occupancy effects on gramicidin A channel lifetime

1988 • 24 citations

Palytoxin-induced permeability changes in excitable membranes

1985 • 21 citations

Sugar moiety of cardiac glycosides is essential for the inhibitory action on the palytoxin‐induced K⁺ release from red blood cells

1984 • 21 citations

Effects of the skin mitogens tumor‐promotor 12‐O‐tetradecanoylphorbol 13‐acetate and divalent‐cation‐ionophore A23187 on ion fluxes and membrane potential in a murine epidermal cell line (HEL30) and in 3T3 fibroblasts

1983 • 16 citations

Lack of interaction of rhodopsin chromophore with membrane lipids. An electron-electron double resonance study using 14N:15N pairs

1988 • 9 citations