Small effects of amino acid replacements on the reduced and unfolded state of pancreatic trypsin inhibitor

Protein Denaturation

1968 • 2,108 citations

DENATURED STATES OF PROTEINS

1991 • 870 citations

Proteins as Random Coils. I. Intrinsic Viscosities and Sedimentation Coefficients in Concentrated Guanidine Hydrochloride

1967 • 545 citations

Reexamination of the Folding of BPTI: Predominance of Native Intermediates

1991 • 505 citations

Characterization of a partly folded protein by NMR methods: studies on the molten globule state of guinea pig .alpha.-lactalbumin

1989 • 473 citations

Kinetic role of a meta-stable native-like two-disulphide species in the folding transition of bovine pancreatic trypsin inhibitor

1984 • 308 citations

Viscosity, Sedimentation, et Cetera, of Ring- and Straight-Chain Polymers in Dilute Solution

1966 • 282 citations

Mutant forms of staphylococcal nuclease with altered patterns of guanidine hydrochloride and urea denaturation

1986 • 275 citations

Solvent denaturation and stabilization of globular proteins

1991 • 260 citations

Electrophoretic analysis of the unfolding of proteins by urea

1979 • 241 citations

Residual structure in large fragments of staphylococcal nuclease: effects of amino acid substitutions

1989 • 234 citations

Probing the stability of a partly folded apomyoglobin intermediate by site-directed mutagenesis

1991 • 179 citations

Circular and circularly permuted forms of bovine pancreatic trypsin inhibitor

1983 • 163 citations

Hydrodynamic Properties of Flexible-Ring Macromolecules

1966 • 145 citations

A magnetization-transfer nuclear magnetic resonance study of the folding of staphylococcal nuclease

1989 • 133 citations

Probing the Determinants of Protein Folding and Stability with Amino Acid Substitutions

1989 • 133 citations

Modeling the effects of mutations on the denatured states of proteins

1992 • 126 citations

Use of site-directed mutagenesis to destabilize native apomyoglobin relative to folding intermediates

1989 • 124 citations

Mutational analysis of a protein-folding pathway

1989 • 111 citations

[22] Structural characterization of protein folding intermediates by proton magnetic resonance and hydrogen exchange

1989 • 105 citations

Circular dichroism spectroscopy of bovine pancreatic trypsin inhibitor and five altered conformational states. Relationship of conformation and the refolding pathway of the trypsin inhibitor

1981 • 85 citations

Kinetic analysis of the folding and unfolding of a mutant form of bovine pancreatic trypsin inhibitor lacking the cysteine-14 and -38 thiols

1988 • 84 citations

Reduced bovine pancreatic trypsin inhibitor has a compact structure

1988 • 60 citations

Circular dichroism, Raman spectroscopy, and gel filtration of trapped folding intermediates of ribonuclease

1981 • 57 citations

A photochemically induced dynamic nuclear polarization study of denatured state of lysozyme

1991 • 52 citations

Detection of local structures in reduced unfolded bovine pancreatic trypsin inhibitor

1992 • 46 citations

On the relevance of non-random polypeptide conformations for protein folding

1988 • 42 citations

Reactivities of the cysteine residues of the reduced pancreatic trypsin inhibitor

1975 • 36 citations

Ultraviolet difference spectroscopy of intermediates trapped in unfolding and refolding of bovine pancreatic trypsin inhibitor

1980 • 35 citations

A Circular Dichroic Spectral Study on Disuffide-Reduced Pancreatic Ribonuclease A and Its Renaturation to the Active Enzyme1

1977 • 33 citations

A genetic screen to identify variants of bovine pancreatic trypsin inhibitor with altered folding energetics

1990 • 31 citations

Genetic dissection of pancreatic trypsin inhibitor.

1992 • 21 citations