DBC1 is a negative regulator of SIRT1

Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

2004 • 3,100 citations

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

2005 • 2,981 citations

hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

2001 • 2,550 citations

Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase

2004 • 2,531 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

2001 • 2,042 citations

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

2001 • 1,892 citations

Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase

2004 • 1,877 citations

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

2004 • 1,847 citations

Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

2000 • 1,756 citations

Mammalian SIRT1 Represses Forkhead Transcription Factors

2004 • 1,352 citations

Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration

2004 • 1,052 citations

Human SirT1 Interacts with Histone H1 and Promotes Formation of Facultative Heterochromatin

2004 • 865 citations

Calorie Restriction— the SIR2 Connection

2005 • 794 citations

Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway

2004 • 660 citations

Tumor Suppressor HIC1 Directly Regulates SIRT1 to Modulate p53-Dependent DNA-Damage Responses

2005 • 637 citations

Sirtuins in Aging and Age-Related Disease

2006 • 613 citations

Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

2004 • 582 citations

Sir2 Regulates Skeletal Muscle Differentiation as a Potential Sensor of the Redox State

2003 • 578 citations

FOXO4 Is Acetylated upon Peroxide Stress and Deacetylated by the Longevity Protein hSir2

2004 • 531 citations

Antitumor Activity of a Small-Molecule Inhibitor of Human Silent Information Regulator 2 Enzymes

2006 • 456 citations

Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage

2006 • 431 citations

Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras–MAPK signaling in human cancer cells

2005 • 422 citations

Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation

2005 • 402 citations

Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation

2006 • 375 citations

Cancer-Specific Functions of SIRT1 Enable Human Epithelial Cancer Cell Growth and Survival

2005 • 291 citations

Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress

2005 • 257 citations

DBC2 , a candidate for a tumor suppressor gene involved in breast cancer

2002 • 207 citations

SIRT1: Tumor promoter or tumor suppressor?

2006 • 88 citations

Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling

2005 • 64 citations