Novel Interactions between Urokinase and Its Receptor

Physiological consequences of loss of plasminogen activator gene function in mice

1994 • 1,051 citations

Regulation of Integrin Function by the Urokinase Receptor

1996 • 734 citations

Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis.

1990 • 624 citations

Identification of the urokinase receptor as an adhesion receptor for vitronectin.

1994 • 593 citations

Kinetic analysis of macromolecular interactions using surface plasmon resonance biosensors

1997 • 540 citations

Plasminogen activation by receptor-bound urokinase. A kinetic study with both cell-associated and isolated receptor

1991 • 509 citations

The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes.

1990 • 480 citations

Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?

1996 • 460 citations

Urokinase plasminogen activator receptor, beta 2-integrins, and Src-kinases within a single receptor complex of human monocytes.

1995 • 355 citations

The urokinase receptor is required for human monocyte chemotaxis in vitro.

1994 • 308 citations

Induction of cell migration by pro-urokinase binding to its receptor: possible mechanism for signal transduction in human epithelial cells.

1994 • 266 citations

Trinodular structure of fibrinogen

1979 • 263 citations

A Model for Fibrinogen: Domains and Sequence

1985 • 257 citations

The Urokinase Receptor Is a Major Vitronectin-Binding Protein on Endothelial Cells

1996 • 252 citations

Carboxyl-terminal portions of the alpha chains of fibrinogen and fibrin. Localization by electron microscopy and the effects of isolated alpha C fragments on polymerization

1993 • 248 citations

Cell Surface Receptors: A Short Course on Theory and Methods

1986 • 246 citations

Requirement of Receptor-bound Urokinase-type Plasminogen Activator for Integrin αvβ5-directed Cell Migration

1996 • 244 citations

A urokinase-sensitive region of the human urokinase receptor is responsible for its chemotactic activity

1997 • 236 citations

Reversible cellular adhesion to vitronectin linked to urokinase receptor occupancy.

1994 • 216 citations

Fibrin deposition in tissues from endotoxin-treated mice correlates with decreases in the expression of urokinase-type but not tissue-type plasminogen activator.

1996 • 197 citations

The urokinase receptor (CD87) facilitates CD11b/CD18-mediated adhesion of human monocytes.

1996 • 196 citations

Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition.

1998 • 194 citations

Comparison of methods for immobilization to carboxymethyl dextran sensor surfaces by analysis of the specific activity of monoclonal antibodies

1995 • 152 citations

Proliferation of a human epidermal tumor cell line stimulated by urokinase

1987 • 132 citations

Single chain urokinase. Augmentation of enzymatic activity upon binding to monocytes

1991 • 110 citations

Interaction of single-chain urokinase-type plasminogen activator with human endothelial cells.

1990 • 109 citations

Domain Interplay in the Urokinase Receptor

1996 • 104 citations

Human urokinase-type plasminogen activator primes neutrophils for superoxide anion release. Possible roles of complement receptor type 3 and calcium.

1995 • 104 citations

Enhancement of the Enzymatic Activity of Single-chain Urokinase Plasminogen Activator by Soluble Urokinase Receptor

1995 • 101 citations

Interaction of urokinase‐type plasminogenactivator (u‐PA) with its cellular receptor (u‐PAR) induces phosphorylation on tyrosine of a 38 kDa protein

1993 • 100 citations

Contrasting Effects of Plasminogen Activators, Urokinase Receptor, and LDL Receptor–Related Protein on Smooth Muscle Cell Migration and Invasion

1996 • 100 citations

Integrin-dependent induction of functional urokinase receptors in primary T lymphocytes.

1996 • 95 citations

Effects of Ligand-Mimetic Peptides Arg-Gly-Asp-X (X = Phe, Trp, Ser) on αIIbβ3 Integrin Conformation and Oligomerization

1999 • 87 citations

Induction of c‐fos gene expression by urokinase‐type plasminogen activator in human ovarian cancer cells

1994 • 63 citations

Mitogenic Effects of Urokinase on Melanoma Cells Are Independent of High Affinity Binding to the Urokinase Receptor

1998 • 61 citations

Interaction of single-chain urokinase with its receptor induces the appearance and disappearance of binding epitopes within the resultant complex for other cell surface proteins

1996 • 53 citations

Urokinase-type plasminogen activator-deficient mice are predisposed to staphylococcal botryomycosis, pleuritis, and effacement of lymphoid follicles.

1997 • 45 citations

Lysis of Plasma Clots by Urokinase-Soluble Urokinase Receptor Complexes

1998 • 41 citations

Soluble Human Urokinase Receptor Is Composed of Two Active Units

1997 • 35 citations

Identification of Receptors Using Direct Radioligand Binding Techniques

1986 • 33 citations

Urokinase-type Plasminogen Activator-induced Monocyte Adhesion Requires a Carboxyl-terminal Lysine and cAMP-dependent Signal Transduction

1995 • 31 citations

Plasminogen Activation by Pro‐Urokinase in Complex with its Receptor — Dependence on a Tripeptide (Spectrozyme Plasmin)

1997 • 19 citations

Interaction of Urokinase-Type Plasminogen Activator with Its Receptor Rapidly Induces Activation of Glucose Transporters

1997 • 18 citations

Conformation of one- and two-chain high molecular weight urokinase analyzed by small-angle neutron scattering and vacuum ultraviolet circular dichroism

1991 • 15 citations

REGULATION OF SINGLE CHAIN UROKINASE BY SMALL PEPTIDES

1996 • 14 citations

Transgenic animals as tools for the study of fibrinolysis in vivo

1994 • 10 citations