A Critical Role for Mouse CXC Chemokine(s) in Pulmonary Neutrophilia During Th Type 1-Dependent Airway Inflammation

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

The expanding universe of T-cell subsets: Th1, Th2 and more

1996 • 3,710 citations

Predominant T_H2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

1992 • 2,802 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.

1996 • 1,382 citations

The Inverse Association Between Tuberculin Responses and Atopic Disorder

1997 • 1,305 citations

Noninvasive Measurement of Airway Responsiveness in Allergic Mice Using Barometric Plethysmography

1997 • 1,294 citations

Bronchoscopic Evaluation of Severe Asthma

1997 • 775 citations

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

1996 • 734 citations

Allergen-specific Th1 cells fail to counterbalance Th2 cell–induced airway hyperreactivity but cause severe airway inflammation

1999 • 642 citations

Sudden-Onset Fatal Asthma: A Distinct Entity with Few Eosinophils and Relatively More Neutrophils in the Airway Submucosa?

1993 • 588 citations

Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures.

1995 • 533 citations

Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses.

1993 • 479 citations

Distinct Role of Antigen-Specific T Helper Type 1 (Th1) and Th2 Cells in Tumor Eradication in Vivo

1999 • 445 citations

Airways obstruction, chronic expectoration, and rapid decline of FEV1 in smokers are associated with increased levels of sputum neutrophils.

1996 • 440 citations

Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-γ

1996 • 420 citations

CD4⁺T-Lymphocytes and Interleukin-5 Mediate Antigen-induced Eosinophil Infiltration into the Mouse Trachea

1992 • 353 citations

Interleukin-8: an important chemoattractant in sputum of patients with chronic inflammatory airway diseases

1993 • 315 citations

Abrogation of Bronchial Eosinophilic Inflammation and Airway Hyperreactivity in Signal Transducers and Activators of Transcription (STAT)6-deficient Mice

1998 • 314 citations

Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice.

1995 • 311 citations

Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation

1999 • 311 citations

T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma.

1996 • 309 citations

IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells.

1998 • 296 citations

CXC Chemokine Receptor CXCR2 Is Essential for Protective Innate Host Response in MurinePseudomonas aeruginosaPneumonia

2000 • 273 citations

Modulation of Airway Inflammation by Passive Transfer of Allergen-Specific Th1 and Th2 Cells in a Mouse Model of Asthma

1999 • 273 citations

Elevated Release of Tumor Necrosis Factor-alpha and Interferon-gamma by Bronchoalveolar Leukocytes from Patients with Bronchial Asthma

1993 • 262 citations

Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils.

1999 • 244 citations

T Helper 1 Cells and Interferon γ Regulate Allergic Airway Inflammation and Mucus Production

1999 • 243 citations

Cutting Edge: IL-4-Independent Induction of Airway Hyperresponsiveness by Th2, But Not Th1, Cells

1998 • 234 citations

Role for macrophage inflammatory protein-2 in lipopolysaccharide-induced lung injury in rats.

1996 • 200 citations

Th2-Induced Airway Mucus Production Is Dependent on IL-4Rα, But Not on Eosinophils

1999 • 192 citations

Requirement for C-X-C chemokines (macrophage inflammatory protein-2 and cytokine-induced neutrophil chemoattractant) in IgG immune complex-induced lung injury.

1997 • 176 citations

Thalamic modulation of high-frequency oscillating potentials in auditory cortex

1996 • 173 citations

lnterleukin-8 in Airway Inflammation in Patients with Asthma and Chronic Obstructive Pulmonary Disease

1996 • 170 citations

Lymphocyte Activation in Bronchoalveolar Lavage and Peripheral Blood in Atopic Asthma

1992 • 152 citations

Cloning, expression, and functional characterization of rat MIP-2: a neutrophil chemoattractant and epithelial cell mitogen

1995 • 152 citations

Soluble IL-4 Receptor Inhibits Airway Inflammation Following Allergen Challenge in a Mouse Model of Asthma

2000 • 151 citations

Physiologic Regulation of Postovulatory Neutrophil Migration into Vagina in Mice by a C-X-C Chemokine(s)

1998 • 85 citations

Therapeutic Effect of Anti-Macrophage Inflammatory Protein 2 Antibody on Influenza Virus-Induced Pneumonia in Mice

2000 • 82 citations

Airway hyperreactivity in patients with sarcoidosis.

1981 • 74 citations

Indispensable Role for TNF-α and IFN-γ at the Effector Phase of Liver Injury Mediated by Th1 Cells Specific to Hepatitis B Virus Surface Antigen

2000 • 66 citations

Rapid Up-Regulation of CXC Chemokines in the Airways after Ag-Specific CD4+ T Cell Activation

2001 • 28 citations

End-tidal CO2 Analysis in Sleep Apnea Syndrome

1993 • 21 citations

Clonal analysis of lung and blood T cells in patients with sarcoidosis.

1994 • 15 citations

A Role for T Helper-1 Cells in the Induction of Airway Hyperresponsiveness

1993 • 8 citations