Poly(ADP‐Ribosyl)ation, Genomic Instability, and Longevity

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

1997 • 1,034 citations

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

1997 • 1,020 citations

PARP-2, A Novel Mammalian DNA Damage-dependent Poly(ADP-ribose) Polymerase

1999 • 713 citations

PARP is important for genomic stability but dispensable in apoptosis

1997 • 556 citations

ADP-ribosylation of proteins. Enzymology and biological significance.

1987 • 374 citations

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

1999 • 372 citations

Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin

1999 • 368 citations

DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines

1998 • 350 citations

Involvement of poly(ADP-ribose) polymerase in base excision repair

1999 • 322 citations

Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span.

1992 • 295 citations

Poly(ADP-ribose) Polymerase Null Mouse Cells Synthesize ADP-ribose Polymers

1998 • 291 citations

Inactivation of the Poly(ADP-ribose) Polymerase Gene Affects Oxygen Radical and Nitric Oxide Toxicity in Islet Cells

1995 • 270 citations

Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability

1999 • 255 citations

Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.

1993 • 242 citations

A dominant-negative mutant of human poly(ADP-ribose) polymerase affects cell recovery, apoptosis, and sister chromatid exchange following DNA damage.

1995 • 200 citations

DNA repair: PARP – another guardian angel?

1998 • 173 citations

A Human Poly(ADP-ribose) Polymerase Gene Family (ADPRTL): cDNA Cloning of Two Novel Poly(ADP-ribose) Polymerase Homologues

1999 • 145 citations

Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians

1998 • 135 citations

trans-Dominant Inhibition of Poly(ADP-Ribosyl)ation Sensitizes Cells against γ-Irradiation and N-Methyl-N′-Nitro-N-Nitrosoguanidine but Does Not Limit DNA Replication of a Polyomavirus Replicon

1995 • 113 citations

3-Aminobenzamide synergistically increases sister-chromatid exchanges in cells exposed to methyl methanesulfonate but not to ultraviolet light

1982 • 107 citations

Inhibition of poly(ADP-ribosyl)ation by overexpressing the poly(ADP-ribose) polymerase DNA-binding domain in mammalian cells.

1990 • 100 citations

pADPRT‐2: a novel mammalian polymerizing(ADP‐ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans¹

1999 • 53 citations

Overexpression of Human poly(ADP‐Ribose) Polymerase in Transfected Hamster Cells Leads to Increased Poly(ADP‐Ribosyl)ation and Cellular Sensitization to γ irradiation

1997 • 52 citations

Trans-dominant inhibition of poly(ADP-ribosyl)ation potentiates carcinogen induced gene amplification in SV40-transformed Chinese hamster cells.

1996 • 43 citations

γ-Radiation induced ADP-ribosyl transferase activity and mammalian longevity

1985 • 38 citations

Molecular Gerontology

1996 • 18 citations

Trans-dominant inhibition of poly(ADP-ribosyl)ation potentiates alkylation-induced shuttle-vector mutagenesis in Chinese hamster cells.

1999 • 17 citations

Maintaining the Stability of the Genome

1996 • 7 citations