Analysis of the role of membrane transport and polyglutamation of methotrexate in gut and the Ehrlich tumor in vivo as factors in drug sensitivity and selectivity.

Carrier-mediated Transport of the Folic Acid Analogue, Methotrexate, in the L1210 Leukemia Cell

1968 • 384 citations

Clinical Pharmacokinetics

1975 • 298 citations

THE BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ACTION AND EFFECTS OF THE FOLIC ACID ANTAGONISTS.

1963 • 156 citations

Evidence for the cytotoxic activity of polyglutamate derivatives of methotrexate.

1980 • 147 citations

Correlates of folate analog transport, pharmacokinetics and selective antitumor action

1980 • 135 citations

Transport and metabolism of methotrexate in normal and resistant cultured rat hepatoma cells.

1979 • 118 citations

Studies with a mathematical model of folate metabolism

1973 • 116 citations

Efflux of methotrexate and its polyglutamate derivatives from hepatic cells in vitro.

1981 • 89 citations

Synthesis of methotrexate polyglutamates in L1210 murine leukemia cells.

1977 • 86 citations

Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissues in vivo.

1981 • 84 citations

Mechanism of action of methotrexate. IV. Free intracellular methotrexate required to suppress dihydrofolate reduction to tetrahydrofolate by Ehrlich ascites tumor cells in vitro.

1976 • 82 citations

Stoichiometric inhibition of mammalian dihydrofolate reductase by the γ-glutamyl metabolite of methotrexate, 4-amino-4-deoxy-N10-methylpteroylglutamyl-γ-glutamate

1975 • 81 citations

Tissue-Specific Synthesis of Methotrexate Polyglutamates in the Rat

1975 • 80 citations

Reversal of methotrexate binding to dihydrofolate reductase by dihydrofolate. Studies with pure enzyme and computer modeling using network thermodynamics.

1979 • 78 citations

Methotrexate polyglutamate synthesis by cultured human breast cancer cells.

1980 • 70 citations

Kinetic correlates of methotrexate transport and therapeutic responsiveness in murine tumors.

1976 • 64 citations

Formation of methotrexate polyglutamates in rat hepatocytes.

1979 • 58 citations

Synthesis of methotrexate polyglutamates in cultured human cells.

1978 • 54 citations

Reactivation of dihydrofolate reductase inhibited by methotrexate or aminopterin

1977 • 43 citations

Application of network thermodynamics to the computer modeling of the pharmacology of anticancer agents: A network model for methotrexate action as a comprehensive example

1981 • 43 citations

Differential cell permeability and the basis for selective activity of methotrexate during therapy of the L1210 leukemia.

1973 • 42 citations

Synthesis of Methotrexate Polyglutamates by Bone Marrow Cells from Patients with Leukemia and Lymphoma

1980 • 41 citations

Further evidence for a basis of selective activity and relative responsiveness during antifolate therapy of murine tumors.

1975 • 38 citations

Extracellular recovery of methotrexate-polyglutamates following efflux from L1210 leukemia cells

1980 • 35 citations

Studies on the enzymatic hydrolysis of polyglutamyl folates by chicken liver folyl poly-γ-glutamyl carboxypeptidase I. Intracellular localization, purification and partial characterization of the enzyme

1977 • 28 citations

Effects of 2,4-dinitrophenol and other metabolic inhibitors on the bidirectional carrier fluxes, net transport, and intracellular binding of methotrexate in Ehrlich ascites tumor cells.

1980 • 23 citations

Some network thermodynamic models of coupled, dynamic physiological systems

1979 • 21 citations

Different effects of vincristine on methotrexate uptake by L1210 cells and mouse intestinal epithelia in vitro and in vivo.

1979 • 20 citations

Transport, growth inhibition and biochemical properties of the gamma-glutamyl and gamma-aspartyl peptides of 2,4-diamino folate analogs in l1210 leukemia cells in vitro. Abstr.

1978 • 2 citations