Studies with a mathematical model of folate metabolism

ENZYMATIC REDUCTION OF FOLIC ACID AND DIHYDROFOLIC ACID TO TETRAHYDROFOLIC ACID

1957 • 416 citations

Carrier-mediated Transport of the Folic Acid Analogue, Methotrexate, in the L1210 Leukemia Cell

1968 • 384 citations

THE CHARACTERISTICS OF THE MEMBRANE TRANSPORT OF AMETHOPTERIN AND THE NATURALLY OCCURRING FOLATES

1971 • 291 citations

Thymidylate synthetase from amethopterin- resistant Lactobacillus casei

1971 • 228 citations

Fluorinated pyrimidines. XXVI. Mammalian thymidylate synthetase: its mechanism of action and inhibition by fluorinated nucleotides.

1965 • 192 citations

THE MECHANISM OF ENZYME-INHIBITOR-SUBSTRATE REACTIONS

1944 • 176 citations

Defective transport of amethopterin (methotrexate) as a mechanism of resistance to the antimetabolite in L5178Y leukemic cells

1962 • 172 citations

Metabolic Control Mechanisms

1964 • 160 citations

Increased levels of folic acid reductase as a mechanism of resistance to amethopterin in leukemic cells

1961 • 152 citations

Cell killing studies on the mode of action of methotrexate on L-cells in vitro.

1969 • 132 citations

On the nature of a transport alteration determining resistance to amethopterin in the L1210 leukemia.

1968 • 129 citations

Uptake as a Determinant of Methotrexate Response in Mouse Leukemias

1965 • 107 citations

Increased Dihydrofolate Reductase Activity as a Possible Basis of Drug Resistance in Leukæmia

1961 • 107 citations

BIOSYNTHESIS OF THE PURINES

1957 • 97 citations

SITES OF ACTION OF AMETHOPTERIN: INTRINSIC AND ACQUIRED DRUG RESISTANCE*

1971 • 87 citations

On the enzymic reduction of folic acid by a purified hydrogenase

1958 • 63 citations

Intracellular pH of the Ehrlich Ascites Tumor Cell as It Is Affected by Sugars and Sugar Derivatives

1967 • 58 citations

Studies relating to the mode of action of methotrexate. 3. Inhibition of thymidylate synthetase in tissue culture cells and in cell-free systems.

1969 • 56 citations

Purification of Thymidylate Synthetase from Ehrlich Ascites Carcinoma Cells

1971 • 41 citations

MATHEMATICAL SIMULATION IN CHEMOTHERAPY*

1971 • 39 citations

[113] Serine hydroxymethylase

1962 • 33 citations

Tetrahydrofolate Cofactors in Tissues Sensitive and Refractory to Amethopterin^*

1966 • 32 citations

Turnover of dihydrofolate reductase in rapidly dividing cells

1973 • 28 citations

Coordinated changes in biochemical patterns: the effect of cytosine arabinoside and methotrexate on leukocytes from patients with acute granulocytic leukemia.

1969 • 24 citations

Sequential Biochemical Alteration to Antifolate Resistance in L121O Leukaemia

1967 • 17 citations

Nutritional factors in the design of more selective antitumor agents.

1969 • 15 citations

On the mechanism of action of some 4-aminoanalogues of folic acid

1961 • 14 citations

Steady states of general multi‐enzyme networks and their associated properties. Computational approaches

1969 • 7 citations

DISCUSSION PAPER: NUMBER OF BINDING SITES AND POSSIBLE MECHANISMS OF ACTION

1971 • 2 citations

[198] N5,N10-methenyltetrahydrofolate cyclohydrolase

1971 • 1 citations