Effects of long-term elevated serum levels of growth hormone on life expectancy of mice: Lessons from transgenic animal models

METALLOTHIONEIN

1986 • 1,606 citations

Effects of Human Growth Hormone in Men over 60 Years Old

1990 • 1,560 citations

Dramatic growth of mice that develop from eggs microinjected with metallothionein–growth hormone fusion genes

1982 • 1,338 citations

GERM-LINE TRANSFORMATION OF MICE

1986 • 1,165 citations

Metallothionein-Human GH Fusion Genes Stimulate Growth of Mice

1983 • 699 citations

Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone

1979 • 517 citations

Human growth hormone DNA sequence and mRNA structure: possible alternative splicing

1981 • 464 citations

Growth Hormone Heterogeneity: Genes, Isohormones, Variants, and Binding Proteins

1991 • 448 citations

Genetic Engineering of Livestock

1989 • 437 citations

Neuroendocrine rhythms and sleep in aging men

1991 • 335 citations

Progressive glomerulosclerosis develops in transgenic mice chronically expressing growth hormone and growth hormone releasing factor but not in those expressing insulinlike growth factor-1.

1988 • 304 citations

Pulsatile Intravenous Growth Hormone (GH) Infusion to Hypophysectomized Rats Increases Insulin-Like Growth Factor I Messenger Ribonucleic Acid in Skeletal Tissues More Effectively than Continuous GH Infusion*

1988 • 264 citations

Tissue-specific expression and dietary regulation of a chimeric phosphoenolpyruvate carboxykinase/bovine growth hormone gene in transgenic mice.

1988 • 243 citations

Histopathology Associated with Elevated Levels of Growth Hormone and Insulin-Like Growth Factor I in Transgenic Mice*

1989 • 229 citations

Psychological Well-Being before and after Growth Hormone Treatment in Adults with Growth Hormone Deficiency

1990 • 197 citations

Effect of Porcine Growth Hormone on Growth and Carcass Composition of the Pig3

1972 • 191 citations

Different Effects of Intermittent and Continuous Growth Hormone (GH) Administration on Serum Somatomedin-C/Insulin-Like Growth Factor I and Liver GH Receptors in Hypophysectomized Rats*

1988 • 188 citations

Production of transgenic mice, rabbits and pigs by microinjection into pronuclei

1985 • 167 citations

Sex differences in the ultradian pattern of plasma growth hormone concentrations in mice

1991 • 165 citations

Metabolic effects of developmental, tissue-, and cell-specific expression of a chimeric phosphoenolpyruvate carboxykinase (GTP)/bovine growth hormone gene in transgenic mice.

1990 • 155 citations

Immunohistochemical localization of metallothionein in cell nucleus and cytoplasm of fetal human liver and kidney and its changes during development

1987 • 148 citations

The Effect of Recombinant Human Growth Hormone on Malnourished Older Individuals

1991 • 146 citations

Growth Allometry of the Organs in Giant Transgenic Mice*

1987 • 136 citations

Pituitary Porcine Growth Hormone (pGH) and a Recombinant pGH Analog Stimulate Pig Growth Performance in a Similar Manner

1988 • 127 citations

Human Growth Hormone Replacement Therapy: Pharmacological and Clinical Aspects

1991 • 126 citations

Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice.

1992 • 113 citations

Ethical Issues in Growth Hormone Therapy

1989 • 98 citations

Use of Gene Transfer to Increase Animal Growth

1985 • 96 citations

Accelerated growth and visceral lesions in transgenic mice expressing foreign genes of the growth hormone family: an overview

1991 • 83 citations

Effects of long-term, low-dose growth hormone therapy on immune function and life expectancy of mice

1991 • 81 citations

THE PHARMACOKINETICS, SAFETY AND ENDOCRINE EFFECTS OF AUTHENTIC BIOSYNTHETIC HUMAN GROWTH HORMONE IN NORMAL SUBJECTS

1989 • 78 citations

Multiple consequences of human growth hormone expression in transgenic mice.

1989 • 75 citations

The GH-Transgenic Mouse as an Experimental Model for Growth Research: Clinical and Pathological Studies

1992 • 70 citations

Beneficial effects of GH replacement therapy in adults

1991 • 67 citations

Highly Improved Precision of the Hypophysectomized Female Rat Body Weight Gain Bioassay for Growth Hormone by Increased Frequency of Injections, Avoidance of Antibody Formation, and Other Simple Modifications*

1987 • 64 citations

A Moloney MLV-Rat Somatotropin Fusion Gene Produces Biologically Active Somatotropin in a Transgenic Pig

1988 • 62 citations

Response by the rat thyro‐parathyroidectomized at birth to growth hormone and to thyroxin given separately or in combination. I. General growth and organ changes

1949 • 59 citations

New Murine Model for Hepatocellular Carcinoma: Transgenic Mice Expressing Metallothionein--Ovine Growth Hormone Fusion Gene

1990 • 56 citations

Differential Regulation of the Rat Phosphoenolpyruvate Carboxykinase Gene Expression in Several Tissues of Transgenic Mice

1992 • 53 citations

Impaired secretion of growth hormone-releasing hormone, growth hormone and IGF-I in elderly men

1991 • 48 citations

Relative growth of the skull and postcranium in giant transgenic mice

1990 • 46 citations

Growth hormone parameters at four ages in intact and castrated male and female cattle

1991 • 43 citations

The gigantism produced in normal rats by injection of the pituitary growth hormone; body growth and organ changes.

1948 • 40 citations

Cardiac morphology in rats with growth hormone-producing tumours*

1985 • 38 citations

Production of transgenic pigs harbouring a rat phosphoenolpyruvate carboxykinase-bovine growth hormone fusion gene.

1990 • 38 citations

Response by the rat thyro‐parathyroidectomized at birth to growth hormone and to thyroxin given separately or in combination III. Skeletal changes: Tibia, metacarpal, and caudal vertebrae

1950 • 37 citations

Age-Related Changes in Growth Hormone and Prolactin Messenger RNA Levels in the Rat.

1990 • 35 citations

Differential regulation of the rat phosphoenolpyruvate carboxykinase gene expression in several tissues of transgenic mice.

1992 • 32 citations

An evaluation of the functions of the 22-kilodalton (kDa), the 20-kDa, and the N-terminal polypeptide forms of human growth hormone using transgenic mice.

1992 • 32 citations

Expression of metallothionein-human growth hormone fusion genes in transgenic mice results in disproportionate skeletal gigantism.

1991 • 30 citations

Wider indications for treatment with biosynthetic human growth hormone in children

1991 • 28 citations

Proteinuria induced by transplantable rat pituitary tumor MtT SA5. Model for homologous protein-overload proteinuria.

1986 • 27 citations

Biosynthetic Human Growth Hormone: Subchronic Toxicity Studies in Rats and Monkeys

1988 • 26 citations

Growth characteristics of metallothionein-human growth hormone transgenic mice as compared to mice selected for high eight-week body weight and unselected controls. I. Body weight gain and external body dimensions.

1991 • 26 citations

4 Treatment of growth hormone deficiency

1986 • 26 citations

Autologous fibroblast implantation. Feasibility and potential problems in gene replacement therapy.

1990 • 26 citations

Influence of exogenous growth hormone (GH) on performance and plasma GH concentrations of female veal calves

1987 • 25 citations

Restoration of Normal Growth Hormone Responsiveness to GHRH in Normal Aged Men by Infusion of Low Amounts of Theophylline

1991 • 23 citations

Developmental regulation and tissue-specific expression of a chimaeric phosphoenolpyruvate carboxykinase/bovine growth hormone gene in transgenic animals.

1990 • 18 citations

Tolerance to self-antigens in transgenic mice.

1990 • 16 citations

Growth characteristics of metallothionein-human growth hormone transgenic mice as compared to mice selected for high eight-week body weight and unselected controls. II. Skeleton.

1991 • 14 citations

Phenotypic and Patho-Morphological Characteristics in a Half-Sib-Family of Transgenic Mice Carrying Foreign MT-HGH Genes

1988 • 13 citations

Gigantism: its induction by growth hormone in the skeleton of intact and hypophysectomized rats, and its failure following thyroidectomy

1965 • 10 citations

A fast detection protocol for screening large numbers of transgenic animals

1989 • 9 citations

Effects of cytidine 5'-diphosphocholine administration on basal and growth hormone-releasing hormone-induced growth hormone secretion in elderly subjects

1991 • 9 citations

Integration of HGH Gene in Transgenic Mice and Transmission to Next Generation

1988 • 7 citations

Suppression of immunological response against a novel gene product delivered by implants of genetically modified fibroblasts.

1990 • 5 citations

Some pathological effects of anterior pituitary growth hormone preparations on swine.

1956 • 1 citations

[Can growth hormone therapy delay normal aging?].

1991 • 1 citations