Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity.

1980 • 1,185 citations

Molecular Diagnosis of Thiopurine S-Methyltransferase Deficiency: Genetic Basis for Azathioprine and Mercaptopurine Intolerance

1997 • 765 citations

6-Mercaptopurine in the Management of Inflammatory Bowel Disease: Short- and Long-Term Toxicity

1989 • 757 citations

Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia

1990 • 657 citations

Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience.

1993 • 501 citations

Human thiopurine methyltransferase pharmacogenetics: Gene sequence polymorphisms*

1997 • 396 citations

Thiopurine pharmacogenetics in leukemia: Correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations

1987 • 345 citations

Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians.

1996 • 321 citations

Thiopurine Methyltransferase Pharmacogenetics: Human Gene Cloning and Characterization of a Common Polymorphism

1996 • 310 citations

A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase.

1995 • 303 citations

Polymorphism of the thiopurine S-methyltransferase gene in African- Americans

1999 • 272 citations

Thiopurine methyltransferase alleles in British and Ghanaian populations

1999 • 245 citations

Sulphasalazine inhibition of thiopurine methyltransferase: possible mechanism for interaction with 6‐mercaptopurine and azathioprine.

1995 • 226 citations

THE IMPORTANCE OF THIOPURINE METHYLTRANSFERASE ACTIVITY FOR THE USE OF AZATHIOPRINE IN TRANSPLANT RECIPIENTS1

1992 • 178 citations

Genotypic and phenotypic analysis of the polymorphic thiopurine S‐methyltransferase gene (TPMT) in a European population

1998 • 171 citations

Olsalazine and 6-mercaptopurine-related bone marrow suppression: A possible drug-drug interaction

1997 • 153 citations

Human thiopurine methyltransferase pharmacogenetics. Kindred with a terminal exon splice junction mutation that results in loss of activity.

1998 • 118 citations

Clinical Implications of Thiopurine Methyltransferase-Optimization of Drug Dosage and Potential Drug Interactions

1998 • 115 citations

Detection of known and new mutations in the thiopurineS-methyltransferase gene by single-strand conformation polymorphism analysis

1998 • 112 citations

Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase.

1995 • 112 citations

Trimethoprim‐sulphamethoxazole‐associated blood dyscrasias. Ten years'experience of the Swedish spontaneous reporting system

1990 • 98 citations

Azathioprine and allopurinol: a potentially dangerous combination

1990 • 91 citations

Isolation of a human thiopurine S-methyltransferase (TPMT) complementary DNA with a single nucleotide transition A719G (TPMT*3C) and its association with loss of TPMT protein and catalytic activity in humans*

1998 • 74 citations

MONITORED HIGH-DOSE AZATHIOPRINE TREATMENT REDUCES ACUTE REJECTION EPISODES AFTER RENAL TRANSPLANTATION

1998 • 59 citations

Should 6- Thioguanine Nucleotides Be Monitored in Heart Transplant Recipients Given Azathioprine?

1996 • 54 citations

Thiol S-methylation in uremia: Erythrocyte enzyme activities and plasma inhibitors

1980 • 51 citations

Long-term antihypertensive therapy with captopril.

1983 • 49 citations

MONITORING OF AZATHIOPRINE-INDUCED IMMUNOSUPPRESSION WITH THIOPURINE METHYLTRANSFERASE ACTIVITY IN KIDNEY TRANSPLANT RECIPIENTS

1995 • 48 citations

Mechanisms of thrombocytopenia in varicella

1979 • 40 citations

Azathioprine Pharmacogenetics: The Relationship between 6-Thioguanine Nucleotides and Thiopurine Methyltransferase in Patients after Heart and Kidney Transplantation

1996 • 40 citations

Neutropenia associated with metronidazole therapy.

1980 • 21 citations

Primary Infection by Human Parvovirus B19

1993 • 17 citations

Parvovirus infection causing red cell aplasia and leukopenia in rheumatoid arthritis

1994 • 12 citations

Human thiopurine methyltransferase pharmacogenetics: Identification of a novel variant allele

1996 • 6 citations