Cachectin/Tumor Necrosis Factor and Lymphotoxin

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

1984 • 1,738 citations

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.

1986 • 1,591 citations

Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones

1986 • 1,521 citations

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

1986 • 1,501 citations

Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon.

1986 • 1,439 citations

Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors

1986 • 1,433 citations

Modulation of endothelial cell hemostatic properties by tumor necrosis factor.

1986 • 1,335 citations

Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance

1986 • 1,305 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Identity of tumour necrosis factor and the macrophage-secreted factor cachectin

1985 • 1,125 citations

ASSOCIATION BETWEEN TUMOUR NECROSIS FACTOR IN SERUM AND FATAL OUTCOME IN PATIENTS WITH MENINGOCOCCAL DISEASE

1987 • 1,108 citations

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF

1988 • 1,105 citations

Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.

1985 • 1,056 citations

THE TREATMENT OF MALIGNAT TUMORS BY REPEATED INOCULATIONS OF ERYSIPELAS

1893 • 946 citations

Human tumor necrosis factor. Production, purification, and characterization.

1985 • 922 citations

Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors.

1985 • 922 citations

The treatment of malignant tumors by repeated inoculations of erysipelas. With a report of ten original cases. 1893.

1991 • 917 citations

Characterization of receptors for human tumour necrosis factor and their regulation by γ-interferon

1985 • 896 citations

BONE-MARROW TRANSPLANTATION IN A PATIENT WITH THE WISKOTT-ALDRICH SYNDROME

1968 • 873 citations

Stimulation of neutrophils by tumor necrosis factor.

1986 • 847 citations

Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells.

1985 • 833 citations

Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo.

1985 • 788 citations

Tumor Necrosis Factor (Cachectin) as an Essential Mediator in Murine Cerebral Malaria

1987 • 749 citations

Two distinct monokines, interleukin 1 and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells.

1986 • 748 citations

Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation.

1988 • 745 citations

Tumour necrosis factor α stimulates resorption and inhibits synthesis of proteoglycan in cartilage

1986 • 742 citations

Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome

1988 • 739 citations

Tumor necrosis factor/cachectin interacts with endothelial cell receptors to induce release of interleukin 1.

1986 • 709 citations

Fibroblast growth enhancing activity of tumor necrosis factor and its relationship to other polypeptide growth factors.

1986 • 674 citations

Tumors secreting human TNF/cachectin induce cachexia in mice

1987 • 634 citations

Molecular Cloning of the Complementary DNA for Human Tumor Necrosis Factor

1985 • 633 citations

Cachectin/TNF and IL-1 Induced by Glucose-Modified Proteins: Role in Normal Tissue Remodeling

1988 • 606 citations

Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits.

1988 • 603 citations

Tumour necrosis factor-α in murine autoimmune 'lupus' nephritis

1988 • 599 citations

An endothelial cell surface factor(s) induced in vitro by lipopolysaccharide, interleukin 1, and tumor necrosis factor-alpha increases neutrophil adherence by a CDw18-dependent mechanism.

1986 • 593 citations

Interleukin 1 induces endothelial cell procoagulant while suppressing cell-surface anticoagulant activity.

1986 • 592 citations

Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression.

1986 • 585 citations

Cytokine activation of vascular endothelium. Effects on tissue-type plasminogen activator and type 1 plasminogen activator inhibitor.

1988 • 561 citations

Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice.

1987 • 560 citations

Tumor necrosis factor is chemotactic for monocytes and polymorphonuclear leukocytes.

1987 • 533 citations

Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors.

1986 • 532 citations

Recombinant human TNF induces production of granulocyte–monocyte colony-stimulating factor

1986 • 528 citations

Synergistic interactions between interleukin 1, tumor necrosis factor, and lymphotoxin in bone resorption.

1987 • 527 citations

A Macrophage Factor Inhibits Adipocyte Gene Expression: An in Vitro Model of Cachexia

1985 • 525 citations

Human Lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization

1985 • 509 citations

Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A,B antigens in vascular endothelial cells and dermal fibroblasts in vitro.

1986 • 496 citations

Endotoxin and tumor necrosis factor induce interleukin-1 gene expression in adult human vascular endothelial cells.

1986 • 496 citations

Immunoregulatory activity of recombinant human tumor necrosis factor (TNF)-alpha: induction of TNF receptors on human T cells and TNF-alpha-mediated enhancement of T cell responses.

1987 • 490 citations

RAISED SERUM LEVELS OF TUMOUR NECROSIS FACTOR IN PARASITIC INFECTIONS

1986 • 469 citations

Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor

1985 • 464 citations

21-TRISOMY/NORMAL MOSAICISM IN AN INTELLIGENT CHILD WITH SOME MONGOLOID CHARACTERS

1963 • 438 citations

The active form of tumor necrosis factor is a trimer.

1987 • 430 citations

Cachectin/tumor necrosis factor induces lethal shock and stress hormone responses in the dog.

1987 • 425 citations

EVIDENCE FOR TUMOUR NECROSIS FACTOR/CACHECTIN PRODUCTION IN CANCER

1987 • 425 citations

Activation of cultured human endothelial cells by recombinant lymphotoxin: comparison with tumor necrosis factor and interleukin 1 species.

1987 • 418 citations

Tumor necrosis factor and interleukin-1β: suppression of food intake by direct action in the central nervous system

1988 • 414 citations

Recombinant tumor necrosis factor and immune interferon act singly and in combination to reorganize human vascular endothelial cell monolayers.

1986 • 401 citations

Macrophages as a source of tumoricidal activity (tumor-necrotizing factor)

1980 • 398 citations

Macrophage growth factor CSF-1 stimulates human monocyte production of interferon, tumor necrosis factor, and colony stimulating activity.

1986 • 397 citations

Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor.

1985 • 394 citations

Production of Lymphotoxin, a Bone-Resorbing Cytokine, by Cultured Human Myeloma Cells

1987 • 386 citations

Alpha and beta human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria.

1985 • 382 citations

Tumor necrosis factor, alone or in combination with IL-2, but not IFN-gamma, is associated with macrophage killing of Mycobacterium avium complex.

1988 • 378 citations

Independent regulation of tumor necrosis factor and lymphotoxin production by human peripheral blood lymphocytes.

1987 • 372 citations

Cell-associated tumor necrosis factor (TNF) as a killing mechanism of activated cytotoxic macrophages.

1987 • 361 citations

Impact of T-cell depletion on outcome of allogeneic bone-marrow transplantation for standardrisk leukaemias.

1987 • 358 citations

Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages

1986 • 344 citations

Studies of endotoxin-induced decrease in lipoprotein lipase activity.

1981 • 333 citations

Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex.

1986 • 312 citations

Cachectin/tumor necrosis factor-alpha formation in human decidua. Potential role of cytokines in infection-induced preterm labor.

1989 • 307 citations

Tumor necrosis factor provokes superoxide anion generation from neutrophils

1986 • 307 citations

Actions of Tumor Necrosis Factor on Cultured Vascular Endothelial Cells: Morphologic Modulation, Growth Inhibition, and Cytotoxicity

1986 • 300 citations

Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet-activating factor.

1988 • 300 citations

CYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY

1968 • 298 citations

Possible importance of macrophage-derived mediators in acute malaria

1981 • 297 citations

Enhancement of human eosinophil cytotoxicity and leukotriene synthesis by biosynthetic (recombinant) granulocyte-macrophage colony-stimulating factor.

1986 • 297 citations

Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor.

1988 • 295 citations

The toxic effects of tumor necrosis factor in vivo and their prevention by cyclooxygenase inhibitors.

1987 • 295 citations

Growth inhibition of Candida albicans by human polymorphonuclear neutrophils: activation by interferon-gamma and tumor necrosis factor.

1986 • 293 citations

Cellular receptor for 125I-labeled tumor necrosis factor: specific binding, affinity labeling, and relationship to sensitivity.

1985 • 287 citations

TUMOUR NECROSIS FACTOR AS AN AUTOCRINE TUMOUR GROWTH FACTOR FOR CHRONIC B-CELL MALIGNANCIES

1988 • 282 citations

Interferons and tumor necrosis factors have similar catabolic effects on 3T3 L1 cells.

1986 • 280 citations

Two monokines, interleukin 1 and tumor necrosis factor, render cultured vascular endothelial cells susceptible to lysis by antibodies circulating during Kawasaki syndrome.

1986 • 275 citations

Lipoprotein lipase suppression in 3T3-L1 cells by an endotoxin-induced mediator from exudate cells.

1982 • 272 citations

Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression

1985 • 266 citations

Hypertriglyceridemia associated with Trypanosoma brucei brucei infection in rabbits: Role of defective triglyceride removal

1980 • 260 citations

Tumor necrosis factor alpha in cerebrospinal fluid during bacterial, but not viral, meningitis. Evaluation in murine model infections and in patients.

1988 • 249 citations

Natural killer (NK) cell-derived hematopoietic colony-inhibiting activity and NK cytotoxic factor. Relationship with tumor necrosis factor and synergism with immune interferon.

1985 • 249 citations

Effect of tumour necrosis factor on cultured human melanoma cells

1975 • 240 citations

Multiple effects of tumor necrosis factor on lipoprotein lipase in vivo.

1987 • 240 citations

Tumour necrosis factor and lymphotoxin genes map close to H–2D in the mouse major histocompatibility complex

1987 • 230 citations

Transcriptional and posttranscriptional regulation of tumor necrosis factor gene expression in human monocytes.

1988 • 227 citations

Receptor Binding and Activation of Polymorphonuclear Neutrophils by Tumor Necrosis Factor-Alpha

1987 • 219 citations

The Primary Role of Lymphoreticnlar Cells in the Mediation of Host Responses to Bacterial Endotoxim

1980 • 212 citations

Weight loss associated with an endotoxin-induced mediator from peritoneal macrophages: The role of cachectin (tumor necrosis factor)

1985 • 205 citations

Lymphotoxin

1988 • 205 citations

Cell cycle-specific effects of tumor necrosis factor.

1984 • 204 citations

CYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY

1968 • 200 citations

Possible roles of tumor necrosis factor in the pathology of malaria.

1987 • 195 citations

Identity of differentiation inducing factor and tumour necrosis factor

1986 • 181 citations

Sensitization and desensitization to lethal effects of tumor necrosis factor and IL-1.

1988 • 179 citations

Regulation of food intake and hepatic protein synthesis by recombinant-derived cytokines

1988 • 178 citations

Effects of Tumour Necrosis Factor Alpha and Interleukin-1 Alpha and Beta on Human Neutrophil Migration, Respiratory Burst and Degranulation

1988 • 178 citations

The 3' untranslated region of the human interferon-beta mRNA has an inhibitory effect on translation.

1987 • 177 citations

Malarial parasites induce TNF production by macrophages.

1988 • 177 citations

Cytotoxic Effect of Lymphocyte-Antigen Interaction in Delayed Hypersensitivity

1967 • 177 citations

Tumor necrosis factor enhances eosinophil toxicity to Schistosoma mansoni larvae.

1986 • 175 citations

Human Recombinant TNF Suppresses Lipoprotein Lipase Activity and Stimulates Lipolysis in 3T3-L1 Cells1

1987 • 175 citations

Evolution of the genome and the genetic code: selection at the dinucleotide level by methylation and polyribonucleotide cleavage.

1989 • 173 citations

Cachectin/tumor necrosis factor mediates changes of skeletal muscle plasma membrane potential.

1986 • 172 citations

DOES ENDOTOXIN CAUSE BOTH THE DISEASE AND PARASITE DEATH IN ACUTE MALARIA AND BABESIOSIS?

1978 • 165 citations

Chemical Treatment of Tumors. V. Isolation of the Hemorrhage-Producing Fraction from <italic>Serratia marcescens (Bacillus prodigiosus)</italic> Culture Filtrate<xref ref-type="fn" rid="fn1"><sup>1</sup></xref>

1943 • 164 citations

Recombinant human tumor necrosis factor-alpha. Regulation of N-formylmethionylleucylphenylalanine receptor affinity and function on human neutrophils.

1988 • 162 citations

The Intestinal Factor in Irreversible Endotoxin Shock

1958 • 159 citations

DNA fragmentation: manifestation of target cell destruction mediated by cytotoxic T-cell lines, lymphotoxin-secreting helper T-cell clones, and cell-free lymphotoxin-containing supernatant.

1986 • 152 citations

Partial purification of a serum factor that causes necrosis of tumors.

1976 • 146 citations

Interactions of granulocytes with the lungs.

1984 • 146 citations

Selective inhibition of synthesis of enzymes for de novo fatty acid biosynthesis by an endotoxin-induced mediator from exudate cells.

1983 • 143 citations

Tumor necrosis factor mediates endotoxic effects in mice

1987 • 140 citations

Effect of endotoxin-induced monokines on glucose metabolism in the muscle cell line L6.

1987 • 135 citations

Protective Effects of Tumor Necrosis Factor in Experimental Legionella pneumophila Infections of Mice via Activation of PMN Function

1988 • 133 citations

Natural killer-sensitive targets stimulate production of TNF-alpha but not TNF-beta (lymphotoxin) by highly purified human peripheral blood large granular lymphocytes.

1986 • 133 citations

Tumor Necrosis Factor Not Detectable in Patients With Clinical Cancer Cachexia

1988 • 133 citations

Production of an anti-tumour cytotoxin by human monocytes.

1981 • 133 citations

Chemical Treatment of Tumors. IX. Reactions of Mice with Primary Subcutaneous Tumors to Injection of a Hemorrhage-Producing Bacterial Polysaccharide<xref ref-type="fn" rid="fn1"><sup>1</sup></xref>

1944 • 133 citations

Development of partial tolerance to the gastrointestinal effects of high doses of recombinant tumor necrosis factor-alpha in rodents.

1987 • 132 citations

Killing of human malaria parasites by macrophage secretory products

1984 • 130 citations

Activation of protein breakdown and prostaglandin E2 production in rat skeletal muscle in fever is signaled by a macrophage product distinct from interleukin 1 or other known monokines.

1988 • 129 citations

Tumor necrosis factor is the major monocyte product that increases complement receptor expression on mature human neutrophils

1988 • 123 citations

Tumour-necrosis factor from the rabbit. II. Production by monocytes

1978 • 116 citations

Tumor necrosis factor-mediated cytotoxicity involves ADP-ribosylation.

1988 • 113 citations

Neutrophil leukocyte emigration induced by endotoxin. Mediator roles of interleukin 1 and tumor necrosis factor alpha 1.

1988 • 112 citations

Recombinant tumor necrosis factor depresses cytochrome P450-dependent microsomal drug metabolism in mice

1986 • 112 citations

The involvement of human tumor necrosis factors-alpha and -beta in the mixed lymphocyte reaction.

1988 • 111 citations

Tumor necrosis factor can induce fever in rats without activating protein breakdown in muscle or lipolysis in adipose tissue.

1988 • 111 citations

Quantification and characterization of high‐affinity membrane receptors for tumor necrosis factor on human leukemic cell lines

1986 • 110 citations

Nonhematopoietic cells selected for resistance to tumor necrosis factor produce tumor necrosis factor.

1986 • 108 citations

Recombinant human cachectin/tumor necrosis factor but not interleukin-1 alpha downregulates lipoprotein lipase gene expression at the transcriptional level in mouse 3T3-L1 adipocytes.

1988 • 107 citations

Tumor necrosis factor production by human monocytes is a regulated event: induction of TNF-alpha-mediated cellular cytotoxicity by endotoxin.

1986 • 105 citations

The genes for lumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) are tandemly arranged on chromosome 17 of the mouse

1986 • 103 citations

Neuropeptide regulation of inflammatory and immunologic responses. The capacity of alpha-melanocyte-stimulating hormone to inhibit tumor necrosis factor and IL-1-inducible biologic responses.

1988 • 103 citations

Expression of tumor necrosis factor receptors on human monocytes and internalization of receptor bound ligand.

1987 • 102 citations

BCG-induced enhancement of endotoxin sensitivity in C3H/HeJ mice. I. In vivo studies.

1980 • 100 citations

Macrophage-mediated cytotoxicity: role of a soluble macrophage cytotoxic factor similar to lymphotoxin and tumor necrosis factor.

1983 • 99 citations

Tissue-specific regulation of guinea pig lipoprotein lipase; effects of nutritional state and of tumor necrosis factor on mRNA levels in adipose tissue, heart and liver

1988 • 98 citations

Species specificity of human and murine tumor necrosis factor. A comparative study of tumor necrosis factor receptors.

1986 • 95 citations

Target cell DNA fragmentation is mediated by lymphotoxin and tumor necrosis factor.

1987 • 94 citations

Tumor necrosis factor inhibits the proliferation of cultured capillary endothelial cells

1987 • 91 citations

Endotoxin-induced serum factor kills malarial parasites in vitro

1981 • 88 citations

Disparate effects of tumor necrosis factor-alpha/cachectin and tumor necrosis factor-beta/lymphotoxin on hematopoietic growth factor production and neutrophil adhesion molecule expression by cultured human endothelial cells.

1987 • 87 citations

A high molecular weight component of the human tumor necrosis factor receptor is associated with cytotoxicity.

1987 • 85 citations

In vitro production of rabbit macrophage tumor cell cytotoxin

1983 • 83 citations

D-Galactosamine Ire atotoxicit Is Associated With Endotoxin Sensitivity and Mediated by Lymphoreticular Cells in Mice

1985 • 83 citations

Lipopolysaccharide (LPS) stimulates fresh human monocytes to lyse actinomycin D-treated WEHI-164 target cells via increased secretion of a monokine similar to tumor necrosis factor.

1985 • 79 citations

Tumor necrosis factor type α (cachectin) stimulates mouse osteoblast-like cells (MC3T3-E1) to produce macrophage-colony stimulating activity and prostaglandin E2

1987 • 78 citations

Tumour-necrosis factor from the rabbit. V. Synthesis in vitro by mononuclear phagocytes from various tissues of normal and BCG-injected rabbits

1981 • 74 citations

Nucleotide sequence of the murine TNF locus, including the TNF-α (tumor necrosis factor) and TNF-β (lymphotoxin) genes

1987 • 69 citations

Action of Bacterial Polysaccharide on Tumors. II. Damage of Sarcoma 37 by Serum of Mice Treated With <italic>Serratia Marcescens</italic> Polysaccharide, and Induced Tolerance

1962 • 69 citations

Lipopolysaccharide-treated RAW 264.7 cells produce a mediator that inhibits lipoprotein lipase in 3T3-L1 cells.

1985 • 66 citations

Central effects of TNF α on thermogenesis and fever in the rat

1988 • 66 citations

Serum containing tumor necrosis factor is cytotoxic for the human malaria parasite Plasmodium falciparum

1983 • 63 citations

Lectin-gold labeling of glycoconjugates in normal and Brattleboro rat papilla: effect of vasopressin

1988 • 62 citations

B-cell activation by lipopolysaccharide. Distinct pathways for induction of mitosis and antibody production.

1977 • 61 citations

Malarial parasites and tumour cells are killed by the same component of tumour necrosis serum.

1984 • 61 citations

Binding and Crosslinking of 125I-Labeled Recombinant Human Tumor Necrosis Factor to Cell Surface Receptors1

1986 • 60 citations

Suggested importance of monokines in pathophysiology of endotoxin shock and malaria

1982 • 59 citations

Identification of a translation inhibitory element (TIE) in the 3′ untranslated region of the human interferon-β mRNA

1988 • 59 citations

Binding of human TNF-α to high-affinity cell surface receptors: Effect of IFN

1986 • 59 citations

Limited effects of recombinant human and murine interleukin 1 and tumour necrosis factor on production of acute phase proteins by cultured rat hepatocytes.

1987 • 58 citations

CYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY

1968 • 57 citations

Differential sensitivity in vivo of lethal and nonlethal malarial parasites to endotoxin-induced serum factor

1982 • 57 citations

Lipoprotein lipase suppression in 3T3-L1 cells by a haematoprotozoan-induced mediator from peritoneal exudate cells

1984 • 52 citations

Correlation between susceptibility to malaria and babesia parasites and to endotoxicity

1982 • 52 citations

Requirement for the continual presence of lipopolysaccharide for production of tumor necrosis factor by thioglycollate‐induced peritoneal murine macrophages

1986 • 52 citations

Assay of a ribonuclease that preferentially hydrolyses mRNAs containing cytokine-derived UA-rich instability sequences

1988 • 52 citations

Structure of human tumor necrosis factor .alpha. derived from recombinant DNA

1987 • 51 citations

Purification of rabbit tumor necrosis factor

1985 • 50 citations

Changes in thermogenesis and brown fat activity in response to tumour necrosis factor in the rat

1987 • 49 citations

Regulation of B cell maturation and differentiation. I. Suppression of pokeweed mitogen-induced B cell differentiation by tumor necrosis factor (TNF).

1987 • 49 citations

Vascular Reactions of Normal and Malignant Tissues <italic>in Vivo</italic>. V. The Rôle of Hypotension in the Action of a Bacterial Polysaccharide on Tumors

1952 • 48 citations

Significance of leukocytes in endotoxic shock

1975 • 48 citations

Crystallization of trimeric recombinant human tumor necrosis factor (cachectin).

1988 • 48 citations

Modulation of receptors and cytotoxic response of tumor necrosis factor-alpha by various lectins.

1986 • 47 citations

Thyroid hormone resistance in a large kindred: Physiologic, biochemical, pharmacologic, and neuropsychologic studies

1989 • 46 citations

Resistance to Babesia spp. and Plasmodium sp. in mice pretreated with an extract of Coxiella burnetii

1979 • 46 citations

Enhancement of resistance to infections by endotoxin-induced serum factor from Mycobacterium bovis BCG-infected mice

1980 • 45 citations

Hypothalamic action of cachectin to alter pituitary hormone release

1989 • 38 citations

Continuous infusion of tumor necrosis factor: Mechanisms of toxicity in the rat

1988 • 37 citations

Chemical Treatment of Tumors. III. Separation of Hemorrhage-Producing Fraction of B. coli Filtrate

1936 • 37 citations

Activation of Lyt-1+ and Lyt-2+ T cell cloned lines: stimulation of proliferation, lymphokine production, and self-destruction.

1985 • 36 citations

Research on the production site of tumor necrosis factor (TNF).

1981 • 36 citations

Macrophages from Babesia and malaria infected mice are primed for monokine release

1984 • 34 citations

Role of first stimulating agents in the production of tumor necrosis factor

1984 • 33 citations

Characterization of a factor from the U937 cell line that enhances the toxicity of human eosinophils to Schistosoma mansoni larvae.

1987 • 33 citations

Serum containing endotoxin-induced tumour necrosis factor substitutes for helper T cells

1976 • 33 citations

Interleukin-1 induces c-fos protooncogene expression in cultured human endothelial cells

1988 • 29 citations

Chemical Treatment of Tumors. IV. Properties of Hemorrhage-Producing Fraction of B. coli Filtrate

1936 • 28 citations

Tumor necrosis factor/cachectin is a less potent inducer of serum amyloid A synthesis than interleukin 1.

1987 • 28 citations

ACTION OF BACTERIAL POLYSACCHARIDE ON TUMORS. III. REPEATED RESPONSE OF SARCOMA 37, IN TOLERANT MICE, TO SERRATIA MARCESCENS ENDOTOXIN.

1963 • 27 citations

Chemical Treatment of Tumors. VIII. Ultracentrifugal and Electrophoretic Analysis of the Hemorrhage-Producing Fraction from <italic>Serratia marcescens (Bacillus prodigiosus)</italic> Culture Filtrate

1943 • 26 citations

Induction of TNF‐like factor by murine macrophage‐like cell line J774.1 on treatment with Sarcophaga lectin

1984 • 24 citations

Lymphotoxin production in AIDS

1986 • 23 citations

Crystallization and preliminary X-ray investigation reveals that tumor necrosis factor is a compact trimer furnished with 3-fold symmetry

1988 • 21 citations

Characterization of macrophage function in Mycobacterium lepraemurium‐infected mice: sensitivity of mice to endotoxin and release of mediators and lysosomal enzymes after endotoxin treatment

1983 • 20 citations

Chemical Treatment of Tumors. VI. Method Employed in Determining the Potency of Hemorrhage-Producing Bacterial Preparations

1943 • 19 citations

Effects of activation on lipoprotein lipase secretion by macrophages. Evidence for autoregulation.

1986 • 18 citations

Cardiac lipoprotein lipase: effects of lipopolysaccharide and tumor necrosis factor

1988 • 18 citations

Cytotoxic effect of tumor necrosis factor on human lymphocytes and specific binding of the factor to the target cells.

1983 • 17 citations

Ontogeny of murine T lymphocytes

1981 • 14 citations

Interferons (IFNs) and tumor necrosis factors (TNFs) in T cell-mediated immune responses against alloantigens. I. influence on the activation of resting and antigenprimed T cells

1988 • 14 citations

What is tumour necrosis factor really for?

1984 • 14 citations

Purified native and recombinant human alpha lymphotoxin [tumor necrosis factor (TNF)-beta] induces inflammatory reactions in normal skin

1987 • 13 citations

Role of mononuclear phagocyte function in endotoxin-induced tumor necrosis

1984 • 13 citations

Effects of tumor necrosis factor (TNF) on lipolytic activities of rat heart

1988 • 12 citations

Endotoxic activities of tumor necrosis factor independent of IL1 secretion by macrophages/monocytes.

1987 • 10 citations

INTERFERON-Y (IFN-Y) AND LYMPHOTOXIN (LT) OR TUMOR-NECROSIS-FACTOR (TNF) SYNERGIZE TO ACTIVATE MACROPHAGES FOR TUMORICIDAL AND SCHISTOSOMULICIDAL FUNCTIONS

1987 • 5 citations

[Mechanisms of production of tumor necrosis factor (TNF)--reconstitution experiment white nude mice].

1984 • 2 citations