Haplotypes extending across ACE are associated with Alzheimer's disease

“Mini-mental state”

1975 • 82,784 citations

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

2001 • 5,526 citations

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

1991 • 4,669 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

Beta blockade during and after myocardial infarction: An overview of the randomized trials

1985 • 3,248 citations

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1995 • 2,028 citations

The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

2000 • 1,770 citations

Clinical diagnosis of Alzheimer's disease: Report of the NINCDS—ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

2011 • 1,523 citations

Linkage Disequilibrium in Humans: Models and Data

2001 • 1,280 citations

Haplotype tagging for the identification of common disease genes

2001 • 1,188 citations

Low-penetrance susceptibility to breast cancer due to CHEK2*1100delC in noncarriers of BRCA1 or BRCA2 mutations

2002 • 1,081 citations

Apolipoprotein E Polymorphism and Cardiovascular Disease: A HuGE Review

2002 • 783 citations

The allelic architecture of human disease genes: common disease-common variant... or not?

2002 • 718 citations

Fundamentals of Genetic Epidemiology

1993 • 691 citations

Bayesian Haplotype Inference for Multiple Linked Single-Nucleotide Polymorphisms

2002 • 656 citations

Cerebrospinal Fluid β-Amyloid(1-42) in Alzheimer Disease

1999 • 631 citations

Estimation of linkage disequilibrium in randomly mating populations

1974 • 625 citations

Dissecting the architecture of a quantitative trait locus in yeast

2002 • 549 citations

Sequence variation in the human angiotensin converting enzyme

1999 • 490 citations

High Cerebrospinal Fluid Tau and Low Amyloid β42 Levels in the Clinical Diagnosis of Alzheimer Disease and Relation to Apolipoprotein E Genotype

1998 • 445 citations

Haplotypes vs single marker linkage disequilibrium tests: what do we gain?

2001 • 444 citations

Linkage disequilibrium and the mapping of complex human traits

2002 • 399 citations

Linkage disequilibrium mapping of complex disease: fantasy or reality?

1998 • 366 citations

Angiotensin-converting Enzyme Degrades Alzheimer Amyloid β-Peptide (Aβ); Retards Aβ Aggregation, Deposition, Fibril Formation; and Inhibits Cytotoxicity

2001 • 339 citations

Measured Haplotype Analysis of the Angiotensin-I Converting Enzyme Gene

1998 • 210 citations

Higher relative, but lower absolute risks of myocardial infarction in women than in men: analysis of some major risk factors in the S <scp>heep</scp> study

1999 • 150 citations

ACE, MTHFR, Factor V Leiden, and APOE Polymorphisms in Patients With Vascular and Alzheimer’s Dementia

1998 • 125 citations

The ACE gene and Alzheimer's disease susceptibility

2000 • 118 citations

Association Between Angiotensin-Converting Enzyme and Alzheimer Disease

2000 • 102 citations

Angiotensin-1-converting enzyme (ACE) plasma concentration is influenced by multiple ACE-linked quantitative trait nucleotides

2002 • 99 citations

Angiotensin converting enzyme and endothelial nitric oxide synthase DNA polymorphisms and late onset Alzheimer's disease

1999 • 99 citations

Fundamentals of Genetic Epidemiology

1994 • 91 citations

Alzheimer's disease : advances in etiology, pathogenesis, and therapeutics

2001 • 89 citations

β-Amyloid (Aβ) protein in cerebrospinal fluid as a biomarker for Alzheimer’s disease

2002 • 83 citations

High-resolution genetic mapping of the ACE-linked QTL influencing circulating ACE activity

2002 • 82 citations

Investigation of association of 13 polymorphisms in eight genes in southeastern African American Alzheimer disease patients as compared to age‐matched controls

2001 • 81 citations

iFRET: An Improved Fluorescence System for DNA-Melting Analysis

2002 • 78 citations

Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population

1999 • 74 citations

Genetic polymorphisms in older subjects with vascular or Alzheimer's dementia

2001 • 73 citations

DNA Polymorphisms of Apolipoprotein B and Angiotensin I-Converting Enzyme Genes and Relationships with Lipid Levels in Italian Patients with Vascular Dementia or Alzheimer’s Disease

1998 • 65 citations

Using meta-analysis to explain the diversity of results in genetic studies of late-onset Alzheimer’s disease and to identify high-risk subgroups

2001 • 62 citations

Gender-specific association of the angiotensin converting enzyme gene with Alzheimer's disease

2000 • 56 citations

Angiotensin converting enzyme deletion allele in different kinds of dementia disorders

1999 • 52 citations

Dipeptidyl carboxypeptidase 1 (DCP1) and butyrylcholinesterase (BCHE) gene interactions with the apolipoprotein E epsilon 4 allele as risk factors in Alzheimer's disease and in Parkinson's disease with coexisting Alzheimer pathology

2000 • 51 citations

Study of the Association between Alzheimer’s Disease and Angiotensin-Converting Enzyme Gene Polymorphism Using DNA from Lymphocytes

2002 • 51 citations

Cardiovascular risk factors and Alzheimer's disease: a genetic association study in a population aged 85 or over

2000 • 50 citations

The angiotensin 1-converting enzyme insertion (I)/deletion (D) polymorphism does not influence the extent of amyloid or tau pathology in patients with sporadic Alzheimer's disease

2002 • 46 citations

Case-control study and meta-analysis of low density lipoprotein receptor-related protein gene exon 3 polymorphism in Alzheimer's disease

2001 • 46 citations

Association between angiotensin-converting enzyme gene and late onset Alzheimer's disease in Han Chinese

2000 • 38 citations

No association between DCP1 genotype and late‐onset Alzheimer disease

2002 • 25 citations

Angiotensin converting enzyme gene polymorphism in Alzheimer's disease

2000 • 11 citations

Angiotensin converting enzyme gene polymorphism in Alzheimer's disease

2000 • 1 citations