Bayesian Haplotype Inference for Multiple Linked Single-Nucleotide Polymorphisms

Maximum Likelihood from Incomplete Data Via the EM Algorithm

1977 • 46,601 citations

A New Statistical Method for Haplotype Reconstruction from Population Data

2001 • 7,499 citations

Identification of the Cystic Fibrosis Gene: Genetic Analysis

1989 • 4,105 citations

Molecular Beacons: Probes that Fluoresce upon Hybridization

1996 • 4,073 citations

Update on Key Emerging Challenges in Cystic Fibrosis

2014 • 3,606 citations

Monte Carlo Strategies in Scientific Computing

2004 • 2,830 citations

Therapy of CF-Patients with Amitriptyline and Placebo - a Randomised, Double-Blind, Placebo-Controlled Phase IIb Multicenter, Cohort-Study

2013 • 2,504 citations

Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population.

1995 • 1,977 citations

Searching for genetic determinants in the new millennium

2000 • 1,878 citations

Detecting Subtle Sequence Signals: a Gibbs Sampling Strategy for Multiple Alignment

1993 • 1,835 citations

Linkage disequilibrium in the human genome

2001 • 1,779 citations

Gene genealogies and the coalescent process.

1990 • 1,776 citations

High-resolution haplotype structure in the human genome

2001 • 1,752 citations

Monte Carlo Strategies in Scientific Computing

2002 • 1,447 citations

Mutation detection and single-molecule counting using isothermal rolling-circle amplification

1998 • 1,384 citations

Are Rare Variants Responsible for Susceptibility to Complex Diseases?

2001 • 1,224 citations

Oxford Surveys in Evolutionary Biology

1989 • 1,010 citations

Complex promoter and coding region β ₂ -adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness

2000 • 971 citations

Haplotype Variation and Linkage Disequilibrium in 313 Human Genes

2001 • 879 citations

Homozygosity Mapping: A Way to Map Human Recessive Traits with the DNA of Inbred Children

1987 • 875 citations

Inference of haplotypes from PCR-amplified samples of diploid populations.

1990 • 773 citations

Mutations in the Gene Encoding for the β₂-adrenergic Receptor in Normal and Asthmatic Subjects

1993 • 633 citations

Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing.

1997 • 624 citations

The Collapsed Gibbs Sampler in Bayesian Computations with Applications to a Gene Regulation Problem

1994 • 623 citations

The Effect of Polymorphisms of the β₂-Adrenergic Receptor on the Response to Regular Use of Albuterol in Asthma

2000 • 560 citations

An E-M algorithm and testing strategy for multiple-locus haplotypes.

1995 • 544 citations

Sequence variation in the human angiotensin converting enzyme

1999 • 490 citations

Haplotypes vs single marker linkage disequilibrium tests: what do we gain?

2001 • 444 citations

Genetic Analysis of Case/Control Data Using Estimated Haplotype Frequencies: Application to APOE Locus Variation and Alzheimer's Disease

2001 • 432 citations

High level multiplex genotyping by MALDI-TOF mass spectrometry

1998 • 416 citations

Accuracy of Haplotype Frequency Estimation for Biallelic Loci, via the Expectation-Maximization Algorithm for Unphased Diploid Genotype Data

2000 • 405 citations

High-Throughput Genotyping with Single Nucleotide Polymorphisms

2001 • 384 citations

Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays

1999 • 381 citations

HAPLO: A Program Using the EM Algorithm to Estimate the Frequencies of Multi-site Haplotypes

1995 • 331 citations

Parallel Genotyping of Human SNPs Using Generic High-density Oligonucleotide Tag Arrays

2000 • 309 citations

Direct haplotyping of kilobase-size DNA using carbon nanotube probes

2000 • 171 citations

Transmission/Disequilibrium Tests Using Multiple Tightly Linked Markers

2000 • 165 citations

Experimentally-derived haplotypes substantially increase the efficiency of linkage disequilibrium studies

2001 • 160 citations

Haplotype of multiple polymorphisms resolved by enzymatic amplification of single DNA molecules.

1990 • 151 citations

Molecular haplotyping of genetic markers 10 kb apart by allele-specific long-range PCR

1996 • 144 citations

Bayesian Analysis of Haplotypes for Linkage Disequilibrium Mapping

2001 • 143 citations

Data Mining Applied to Linkage Disequilibrium Mapping

2000 • 138 citations

Protection against bronchial asthma by CFTR ΔF508 mutation: A heterozygote advantage in cystic fibrosis

1995 • 130 citations

The Accuracy of Statistical Methods for Estimation of Haplotype Frequencies: An Example from the CD4 Locus

2000 • 128 citations

A cladistic analysis of phenotypic associations with haplotypes inferred from restriction endonuclease mapping or DNA sequencing. V. Analysis of case/control sampling designs: Alzheimer's disease and the apoprotein E locus.

1995 • 124 citations

Angiotensin Converting Enzyme Gene Insertion/Deletion Polymorphism and Cardiovascular Disease

2002 • 119 citations

Characterizing a Joint Probability Distribution by Conditionals

1993 • 99 citations

Fine genetic mapping using haplotype analysis and the missing data problem

1998 • 95 citations

Logistic regression model for analyzing extended haplotype data

1998 • 74 citations

Notes from the SNP vs. haplotype front

2001 • 62 citations

Homogeneous Assays for Single-Nucleotide Polymorphism Typing Using AlphaScreen

2001 • 59 citations

Fine genetic mapping using haplotype analysis and the missing data problem

1998 • 56 citations

A new vector for recombination-based cloning of large DNA fragments from yeast artificial chromosomes

1995 • 52 citations

Predictive Updating Methods with Application to Bayesian Classification

1996 • 37 citations

Data mining: Efficiency of using sequence databases for polymorphism discovery

2001 • 29 citations

Cladistic analysis: its applications in association studies of complex diseases.

2000 • 4 citations

Detection of Novel ALAD Gene Polymorphisms Using Denaturing High-Performance Liquid Chromatography

2001 • 3 citations