Genomics of the major histocompatibility complex: haplotypes, duplication, retroviruses and disease

A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis

1996 • 3,682 citations

Histocompatibility Testing

1971 • 1,937 citations

The evolutionary dynamics of repetitive DNA in eukaryotes

1994 • 1,584 citations

Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells

1998 • 1,134 citations

NONVIRAL RETROPOSONS: GENES, PSEUDOGENES, AND TRANSPOSABLE ELEMENTS GENERATED BY THE REVERSE FLOW OF GENETIC INFORMATION

1986 • 1,032 citations

Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium.

1996 • 1,010 citations

HLA and Disease Associations

1985 • 893 citations

A second lineage of mammalian major histocompatibility complex class I genes.

1994 • 779 citations

The viruses in all of us: characteristics and biological significance of human endogenous retrovirus sequences.

1996 • 684 citations

A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway

1990 • 644 citations

Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus.

1990 • 643 citations

The origin of interspersed repeats in the human genome

1996 • 595 citations

Structure of human steroid 21-hydroxylase genes.

1986 • 568 citations

Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF‐a and TNF‐0 by human mononuclear cells: a possible link to insulin‐dependent diabetes mellitus

1993 • 562 citations

Complete nucleotide sequence of two steroid 21-hydroxylase genes tandemly arranged in human chromosome: a pseudogene and a genuine gene.

1986 • 559 citations

Nomenclature for the major histocompatibility complexes of different species: a proposal

1990 • 546 citations

Family study of the major histocompatibility complex in patients with systemic lupus erythematosus: importance of null alleles of C4A and C4B in determining disease susceptibility.

1983 • 456 citations

Origin of major histocompatibility complex polymorphism: The trans-species hypothesis

1987 • 450 citations

HL-A, IMMUNE-RESPONSE GENES, AND DISEASE

1974 • 449 citations

Inhibition of Lymphocyte Proliferation by a Synthetic Peptide Homologous to Retroviral Envelope Proteins

1985 • 433 citations

A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B

1984 • 433 citations

Isolation of an Active Human Transposable Element

1991 • 433 citations

Nature of polymorphism in HLA-A, -B, and -C molecules.

1988 • 379 citations

Large-scale search for genes on which positive selection may operate

1996 • 367 citations

Triplet repeat polymorphism in the transmembrane region of the MICA gene: A strong association of six GCT repetitions with Behçet disease

1997 • 366 citations

HLA-A and B polymorphisms predate the divergence of humans and chimpanzees

1988 • 341 citations

Insertional mutagenesis of the myc locus by a LINE-1 sequence in a human breast carcinoma

1988 • 320 citations

Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex.

1986 • 312 citations

Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology

1994 • 311 citations

Clonal deletion of V β814-bearing T cells in mice transgenic for mammary tumour virus

1991 • 277 citations

Disease Associations with Complotypes, Supratypes and Haplotypes

1983 • 276 citations

Highly Informative Typing of the Human TNF Locus Using Six Adjacent Polymorphic Markers

1993 • 273 citations

Ancestral haplotypes: conserved population MHC haplotypes

1992 • 255 citations

New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci

1992 • 251 citations

Gene map of the cow: conservation of linkage with mouse and man

1986 • 241 citations

Diversity and diversification of HLA-A,B,C alleles.

1989 • 224 citations

Relationship between C4 null genes, HLA-D region antigens, and genetic susceptibility to systemic lupus erythematosus in Caucasian and Black Americans

1986 • 223 citations

Structural basis of the polymorphism of human complement components C4A and C4B: gene size, reactivity and antigenicity.

1986 • 220 citations

HLA‐B27 polymorphism and worldwide susceptibility to ankylosing spondylitis

1997 • 218 citations

Endogenous Human Retroviruses

1994 • 215 citations

A Virus-Encoded "Superantigen" in a Retrovirus-Induced Immunodeficiency Syndrome of Mice

1991 • 198 citations

Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplication.

1994 • 190 citations

DNA sequence polymorphism at the human tumor necrosis factor (TNF) locus. Numerous TNF/lymphotoxin alleles tagged by two closely linked microsatellites in the upstream region of the lymphotoxin (TNF-beta) gene.

1991 • 186 citations

Transcript encoded on the opposite strand of the human steroid 21-hydroxylase/complement component C4 gene locus.

1989 • 164 citations

Sequence-Dependent Gene Conversion: Can Duplicated Genes Diverge Fast Enough to Escape Conversion?

1987 • 161 citations

Allelic repertoire of the humanMHC class IMICA gene

1996 • 160 citations

HLA-DR beta genes vary in number between different DR specificities, whereas the number of DQ beta genes is constant.

1985 • 154 citations

Polymorphic MHC ancestral haplotypes affect the activity of tumour necrosis factor-alpha

1993 • 151 citations

A new polymorphic and multicopy MHC gene family related to nonmammalian class I

1994 • 150 citations

The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates

1994 • 145 citations

Association between HLA‐DR2 and Production of Tumour Necrosis Factor α and Interleukin 1 by Mononuclear Cells Activated by Lipopolysaccharide

1988 • 144 citations

Retroviral and pseudogene insertion sites reveal the lineage of human salivary and pancreatic amylase genes from a single gene during primate evolution.

1990 • 144 citations

Characterization of the MHC class II region in cattle. The number of DQ genes varies between haplotypes

1988 • 139 citations

Comparison of Class I MHC Alleles in Humans and Apes

1990 • 137 citations

Linkage Analysis of Human Leukocyte Antigen (HLA) Markers in Familial Psoriasis: Strong Disequilibrium Effects Provide Evidence for a Major Determinant in the HLA-B/-C Region

1998 • 133 citations

An approach to the localization of the susceptibility genes for generalized myasthenia gravis by mapping recombinant ancestral haplotypes

1992 • 133 citations

Deletion of C4A genes in patients with systemic lupus erythematosus

1987 • 127 citations

Evolutionary study of multigenic families mapping close to the human MHC class I region

1993 • 123 citations

The complete exon-intron structure of a human complement component C4A gene. DNA sequences, polymorphism, and linkage to the 21-hydroxylase gene.

1991 • 122 citations

Mechanism and consequences of the duplication of the human C4/P450c21/gene X locus.

1992 • 110 citations

Ancestral haplotypes reveal the role of the central MHC in the immunogenetics of IDDM

1992 • 109 citations

Nucleotide Sequence Analysis of the HLA Class I Region Spanning the 237-kb Segment around the HLA-B and -C Genes

1997 • 108 citations

Expression of hemochromatosis in homozygous subjects

1990 • 107 citations

DEFICIENCY OF C4A IS A GENETIC DETERMINANT OF SYSTEMIC LUPUS ERYTHEMATOSUS IN THREE ETHNIC GROUPS

1987 • 102 citations

Null alleles of the fourth component of complement and HLA haplotypes in familial systemic lupus erythematosus

1985 • 96 citations

Improvement in chronic hepatocerebral degeneration following liver transplantation

1990 • 93 citations

Possible protective role of HLA‐B*2706 for ankylosing spondylitis

1997 • 90 citations

TNF, Apoptosis and Autoimmunity: A Common Thread?

1998 • 89 citations

Genetic predisposition to HIV-1 infection and acquired immune deficiency virus syndrome

1995 • 88 citations

Retroelements in the human MHC class II region

1998 • 87 citations

A 1.1-Mb Transcript Map of the Hereditary Hemochromatosis Locus

1997 • 84 citations

Nucleotide Sequencing Analysis of the 146-Kilobase Segment around theIkBLandMICAGenes at the Centromeric End of the HLA Class I Region

1998 • 82 citations

Identification in the HLA class I region of a gene expressed late in keratinocyte differentiation.

1993 • 81 citations

Cluster of fibronectin type III repeats found in the human major histocompatibility complex class III region shows the highest homology with the repeats in an extracellular matrix protein, tenascin

1992 • 81 citations

The Evolution of MHC Diversity by Segmental Duplication and Transposition of Retroelements

1997 • 81 citations

The conundrum of nonclassical major histocompatibility complex genes.

1994 • 79 citations

Major histocompatibility complex genes influence the outcome of HIV infection

1990 • 76 citations

Microsatellite polymorphism between the tumor necrosis factor and HLA-B genes in Behçet's disease

1995 • 76 citations

A novel coding sequence belonging to a new multicopy gene family mapping within the human MHC class I region

1993 • 75 citations

A Review of the Molecular and Cellular Biology of Butyrophilin, the Major Protein of Bovine Milk Fat Globule Membrane

1993 • 74 citations

Immune suppression gene on HLA-Bw54-DR4-DRw53 haplotype controls nonresponsiveness in humans to hepatitis B surface antigen via CD8+ suppressor T cells

1988 • 74 citations

Association of complement C4 and HLA-DR alleles with systemic lupus erythematosus in Koreans.

1994 • 73 citations

A Comparative Genetic Map of Rat, Mouse and Human Genomes.

1998 • 69 citations

Coevolution of PERB11 (MIC) and HLA Class I Genes with HERV-16 and Retroelements by Extended Genomic Duplication

1999 • 68 citations

C4A gene deletion and HLA associations in black Americans with systemic lupus erythematosus

1989 • 68 citations

Linkage of TATA-Binding Protein and Proteasome Subunit C5 Genes in Mice and Humans Reveals Synteny Conserved between Mammals and Invertebrates

1997 • 67 citations

Olfactory Receptor-like Genes Are Located in the Human Major Histocompatibility Complex

1995 • 66 citations

Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus in southern chinese

1992 • 65 citations

Major histocompatibility complex (MHC) complement deficiency, ancestral haplotypes and systemic lupus erythematosus (SLE): C4 deficiency explains some but not all of the influence of the MHC.

1991 • 64 citations

The major histocompatability complex (MHC) contains conserved polymorphic genomic sequences that are shuffled by recombination to form ethnic-specific haplotypes

1997 • 61 citations

The complete genomic sequence of 424,015 bp at the centromeric end of the HLA class I region: Gene content and polymorphism

1998 • 60 citations

Accurate size comparison of short tandem repeat alleles amplified by PCR.

1995 • 58 citations

Extracellular matrix protein tenascin-like gene found in human MHC class III region

1992 • 56 citations

Cloning of a New "Finger" Protein Gene (ZNF173) within the Class I Region of the Human MHC

1995 • 56 citations

New Insights into the Genomic Organization and Origin of the Major Histocompatibility Complex: Role of Chromosomal (genome) Duplication in the Emergence of the Adaptive Immune System

2004 • 54 citations

MICA gene and ankylosing spondylitis: linkage analysis via a transmembrane‐encoded triplet repeat polymorphism

1997 • 53 citations

Cloning, localization, and structure of new members of the butyrophilin gene family in the juxta-telomeric region of the major histocompatibility complex

1997 • 48 citations

TNF microsatellite a2, b3 and d2 alleles are associated with systemic lupus erythematosus

1997 • 48 citations

Characterisation of the novel gene G11 lying adjacent to the complement C4A gene in the human major histocompatibility complex

1994 • 48 citations

A promoter within intron 35 of the human C4A gene initiates abundant adrenal-specific transcription of a 1 kb RNA: location of a cryptic CYP21 promoter element?

1995 • 47 citations

Glucosephosphate Isomerase (GPI) Deficiency Mutations Associated with Hereditary Nonspherocytic Hemolytic Anemia (HNSHA)

1997 • 47 citations

Cloning, Characterization, and the Complete 56.8-Kilobase DNA Sequence of the Human NOTCH4 Gene

1998 • 47 citations

Class I gene contraction within the HLA-A subregion of the human MHC

1992 • 46 citations

Allelic repertoire of the human MICB gene

1997 • 46 citations

New major histocompatibility complex genes

1993 • 44 citations

Physical mapping of the human and mouse MOG gene at the distal end of the MHC class Ib region

1995 • 44 citations

Associations of antibodies to native DNA with HLA-DRw3. A possible major histocompatibility complex-linked human immune response gene.

1980 • 43 citations

Cloning and sequence analysis of human butyrophilin reveals a potential receptor function

1996 • 43 citations

Mapping of bovine markers CYP21, PRL, and BOLA DRBP1 by genetic linkage analysis in reference pedigrees

1992 • 42 citations

Lack of gene deletion for complement C4A deficiency in Japanese patients with systemic lupus erythematosus.

1990 • 41 citations

Partial C4A deficiency is associated with susceptibility to systemic lupus erythematosus in black americans

1988 • 40 citations

The Human Myelin Oligodendrocyte Glycoprotein (MOG) Gene: Complete Nucleotide Sequence and Structural Characterization

1995 • 38 citations

Current status of the swine leukocyte antigen complex

1994 • 37 citations

Allelic and interlocus comparison of the PERB11 multigene family in the MHC

1997 • 34 citations

HLA‐B27 presents a peptide from a polymorphic region of its own molecule with homology to proteins from arthritogenic bacteria

1997 • 33 citations

Molecular analysis of the rat MHC. II. Isolation of genes that map to the RT1.E-grc region.

1989 • 32 citations

Avoidance of inter-repeat recombination by sequence divergence and a mechanism of neutral evolution

1991 • 32 citations

A first map of the porcine major histocompatibility complex class I region

1998 • 32 citations

Three highly polymorphic microsatellites at the human myelin oligodendrocyte glycoprotein locus, 100 kb telomeric to HLA-F

1995 • 31 citations

Differences in the central major histocompatibility complex between humans and chimpanzees implications for development of autoimmunity and acquired immune deficiency syndrome

1993 • 29 citations

Serological and molecular analysis of HLA class I and II alleles in Thai patients with psoriasis vulgaris

1998 • 29 citations

Mapping of H2-M homolog and MOG genes in the rat MHC

1995 • 29 citations

Chromosomal localization of HSP70 genes in cattle

1993 • 29 citations

PERB11 (MIC): a polymorphic MHC gene is expressed in skin and single nucleotide polymorphisms are associated with psoriasis

2000 • 27 citations

Characterization of 4AOHW cell line panel including new data for the 10IHW panel

1993 • 27 citations

Duplication and Polymorphism in the MHC: Alu Generated Diversity and Polymorphism Within the PERB11 Gene Family

2004 • 27 citations

Three Genes Encoding Zinc Finger Proteins on Human Chromosome 6p21.3: Members of a New Subclass of the Krüppel Gene Family Containing the Conserved SCAN Box Domain

1997 • 26 citations

Propeptide processing during factor IX biosynthesis. Effect of point mutations adjacent to the propeptide cleavage site.

1993 • 25 citations

Mapping of C2, Bf, and C4 genes to the swine major histocompatibility complex (swine leukocyte antigen).

1987 • 25 citations

Hereditary Hemochromatosis: Generation of a Transcription Map within a Refined and Extended Map of the HLA Class I Region

1996 • 23 citations

Structural Analysis of the HLA-A/HLA-F Subregion: Precise Localization of Two New Multigene Families Closely Associated with the HLA Class I Sequences

1996 • 22 citations

DQCAR microsatellite polymorphisms in three selected HLA class II‐associated diseases

1995 • 21 citations

The genomic structure of two ancestral haplotypes carrying C4A duplications

1991 • 21 citations

Organization and evolution of C4 and CYP21 genes in primates: importance of genomic segments

1993 • 20 citations

Mapping and genetic organization of the TNF genes in the swine Mhc

1991 • 19 citations

Fine mapping of the crossover-sites in theC4-H-2D region ofH-2 recombinant mouse strains

1991 • 19 citations

Unusual immunoglobulin DNA sequences from the nonexpressed chromosome of mouse normal B lymphocytes: implications for allelic exclusion and the DNA rearrangement process.

1987 • 18 citations

Evolution of class I major histocompatibility complex genes and molecules in humans and apes

1991 • 17 citations

Antibody reactivity profiles following immunization with diverse peptides of the PERB11 (MIC) family

1996 • 16 citations

The mouse HFE gene

1997 • 16 citations

Frequency of HLA‐B27 subtypes in a Danish population and in Danish patients with ankylosing spondylitis

1997 • 16 citations

Biological Significance of Human Endogenous Retroviral Sequences

1996 • 14 citations

Genetic mapping of C4 and Bf complement genes in the rat major histocompatibility complex

1988 • 14 citations

A region centromeric of the major histocampatibility complex class I region is as highly polymorphic as HLA-B implications for recombination

1993 • 14 citations

Visual Demonstration of the Organization of the Human Complement C4 and 21-Hydroxylase Genes by High-Resolution Fluorescencein SituHybridization

1996 • 13 citations

Retroelements and Segmental Duplications in the Generation of Diversity within the MHC

1997 • 13 citations

MIC genes in non-human primates

1999 • 10 citations

Linkage of complement factor B gene to the bovine major histocompatibility complex

1989 • 9 citations

The human complement C4B/steroid 21-hydroxylase (CYP21) and complement C4A/21-hydroxylase pseudogene (CYP21P) intergenic sequences: Comparison and identification of possible regulatory elements

1992 • 9 citations

The clinical significance of anticytoplasmic antibodies found on fluorescent antinuclear antibody testing.

1983 • 9 citations

TAP2 gene polymorphism segregates with DR-DQ in DR/DP recombinant siblings

1993 • 6 citations

Cloning of the cDNAs coding for cat growth hormone and prolactin

1996 • 5 citations

Homology models for the PERB11 multigene family

1998 • 4 citations

MHC and Disease Associations in Nonhuman Primates

1997 • 3 citations

Cloning, Sequencing and Evolutionary Analyses of the Human Major Histocompatibility Complex (MHC) Region

1996 • 2 citations

Rapid communication: TaqI restriction fragment length polymorphism at the porcine transporter associated with antigen processing 2 (TAP2) locus2

1994 • 2 citations