Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF‐a and TNF‐0 by human mononuclear cells: a possible link to insulin‐dependent diabetes mellitus

Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.

1989 • 3,458 citations

Tumor necrosis factor Characterization at the molecular, cellular and in vivo level

1991 • 708 citations

Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus.

1990 • 643 citations

Tumour necrosis factor-α in murine autoimmune 'lupus' nephritis

1988 • 599 citations

Tumor necrosis factor.

1991 • 568 citations

Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production.

1991 • 553 citations

Human Lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization

1985 • 509 citations

Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1.

1990 • 356 citations

Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes.

1987 • 351 citations

[1] High-efficiency cloning of full-length cDNA; Construction and screening of cDNA expression libraries for mammalian cells

1987 • 329 citations

Affinity-purified human Interleukin I is cytotoxic to isolated islets of Langerhans

1986 • 321 citations

Increased tumor necrosis factor and IL-1 beta gene expression in the kidneys of mice with lupus nephritis.

1988 • 321 citations

Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex.

1986 • 312 citations

Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta-cell cytotoxicity.

1987 • 305 citations

Destruction of Rat Islet Cell Monolayers by Cytokines: Synergistic Interactions of Interferon-γ, Tumor Necrosis Factor, Lymphotoxin, and Interleukin 1

1988 • 296 citations

Endotoxin‐Stimulated Human Monocyte Secretion of Interleukin 1, Tumour Necrosis Factor Alpha, and Prostaglandin E₂ Shows Stable Interindividual Differences

1988 • 266 citations

Molecular mapping of the human major histocompatibility complex by pulsed-field gel electrophoresis.

1987 • 237 citations

Tumour necrosis factor and lymphotoxin genes map close to H–2D in the mouse major histocompatibility complex

1987 • 230 citations

Lymphotoxin

1988 • 205 citations

DNA sequence polymorphism at the human tumor necrosis factor (TNF) locus. Numerous TNF/lymphotoxin alleles tagged by two closely linked microsatellites in the upstream region of the lymphotoxin (TNF-beta) gene.

1991 • 186 citations

Cytokines and Free Radicals as Effector Molecules in the Destruction of Pancreatic Beta Cells

1990 • 185 citations

Recombinant human tumor necrosis factor alpha suppresses autoimmune diabetes in nonobese diabetic mice.

1989 • 180 citations

Cytokines Cause Functional and Structural Damage to Isolated Islets of Langerhans

1985 • 180 citations

The Common Mediator of Shock, Cachexia, and Tumor Necrosis

1988 • 175 citations

Measurement of immunoreactive interleukin-1β from human mononuclear cells: Optimization of recovery, intrasubject consistency, and comparison with interleukin-1α and tumor necrosis factor

1988 • 173 citations

Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes.

1991 • 171 citations

A Tumour Necrosis Factor Beta Gene Polymorphism in Relation to Monokine Secretion and Insulin‐Dependent Diabetes Mellitus

1991 • 156 citations

Association between HLA‐DR2 and Production of Tumour Necrosis Factor α and Interleukin 1 by Mononuclear Cells Activated by Lipopolysaccharide

1988 • 144 citations

Genes encoding tumor necrosis factor alpha and granzyme A are expressed during development of autoimmune diabetes.

1990 • 134 citations

Tandem Arrangement of Genes Coding for Tumor Necrosis Factor (TNF- ) and Lymphotoxin (TNF- ) in the Human Genome

1986 • 133 citations

Involvement of class II MHC molecules in the LPS-induction of IL-1/TNF secretions by human monocytes. Quantitative differences at the polymorphic level.

1989 • 108 citations

Nco I Restriction Fragment Length Polymorphism (RFLP) of the Tumor Necrosis Factor (TNFα) region in four autoimmune diseases

1989 • 89 citations

New, sensitive rocket immunoelectrophoretic assay for measurement of the reaction between endotoxin and Limulus amoebocyte lysate

1983 • 86 citations

Cytokine gene expression in the islets of the diabetic Biobreeding/Worcester rat.

1991 • 81 citations

Some disease-associated ancestral haplotypes carry a polymorphism of TNF

1989 • 79 citations

Interleukin-1 induced impairment in pancreatic islet oxidative metabolism of glucose is potentiated by tumor necrosis factor

1988 • 78 citations

HLA associations in insulin‐dependent diabetes: search for heterogeneity in different groups of patients from a homogeneous population

1986 • 74 citations

Polymorphisms in the tumor necrosis factor alpha (TNF-alpha) gene correlate with murine resistance to development of toxoplasmic encephalitis and with levels of TNF-alpha mRNA in infected brain tissue.

1992 • 72 citations

NcoI Restriction Fragment Length Polymorphism (RFLP) of the Tumour Necrosis Factor (TNFα) Region in Primary Biliary Cirrhosis and in Healthy Danes

1989 • 71 citations

Mouse lymphotoxin and tumor necrosis factor: structural analysis of the cloned genes, physical linkage, and chromosomal position.

1987 • 71 citations

TNF-? gene polymorphisms in Type 1 (insulin-dependent) diabetes mellitus

1989 • 64 citations

Monocyte Function in IDDM Patients and Healthy Individuals

1990 • 60 citations

The susceptibility to insulin-dependent diabetes mellitus bis associated with C4 allotypes independently of the association with HLA-DQ alleles in HLA-DR3, 4 heterozygotes

1988 • 60 citations

Conservation of the central MHC genome: PFGE mapping and RFLP analysis of complement, HSP70, and TNF genes in the goat

1990 • 57 citations

Tumour necrosis factor alpha production is upregulated in diabetes prone BB rats

1990 • 50 citations

Localization of the genes for tumor necrosis factor and lymphotoxin between the HLA class I and III regions by field inversion gel electrophoresis

1988 • 43 citations

Low Degree of DNA Polymorphism in the HLA‐Linked Lymphotoxin (Tumour Necrosis Factor β) Gene

1988 • 42 citations

Allelic Variation in the TNF‐β Gene Does Not Explain the Low TNF‐β Response in Patients With Primary Biliary Cirrhosis

1991 • 29 citations

The porcine tumor necrosis factor-encoding genes: sequence and comparative analysis

1991 • 25 citations

Mapping and genetic organization of the TNF genes in the swine Mhc

1991 • 19 citations

The Effect of HLA and Insulin‐Dependent Diabetes Mellitus on the Secretion Levels of Tumour Necrosis Factors Alpha and Beta and Gamma Interferon

1990 • 17 citations

Deleted Work

1955 • 0 citations