A Virus-Encoded "Superantigen" in a Retrovirus-Induced Immunodeficiency Syndrome of Mice

Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.

1989 • 2,118 citations

The Staphylococcal Enterotoxins and Their Relatives

1990 • 1,914 citations

The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice

1989 • 1,095 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

Interaction of Staphylococcus aureus toxin "superantigens" with human T cells.

1989 • 1,000 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor.

1985 • 676 citations

The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens

1988 • 491 citations

T cell stimulation by staphylococcal enterotoxins. Clonally variable response and requirement for major histocompatibility complex class II molecules on accessory or target cells.

1988 • 427 citations

T‐Cell Responses to Mls and to Bacterial Proteins that Mimic its Behavior^#

1989 • 337 citations

The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cells.

1989 • 331 citations

Retroviral induction of acute lymphoproliferative disease and profound immunosuppression in adult C57BL/6 mice.

1985 • 310 citations

Identification of homologous regions in human immunodeficiency virus I gp41 and human MHC class II beta 1 domain. I. Monoclonal antibodies against the gp41-derived peptide and patients' sera react with native HLA class II antigens, suggesting a role for autoimmunity in the pathogenesis of acquired immune deficiency syndrome.

1988 • 268 citations

Severe immunodeficiency disease induced by a defective murine leukaemia virus

1989 • 258 citations

Identification of the region of T cell receptor β chain that interacts with the self-superantigen MIs-1a

1990 • 242 citations

An explanation for the protective effect of the MHC class II I–E molecule in murine diabetes

1989 • 216 citations

Defective virus is associated with induction of murine retrovirus-induced immunodeficiency syndrome.

1989 • 209 citations

Characterization of monoclonal antibodies reactive with murine leukemia viruses: Use in analysis of strains of friend MCF and friend ecotropic murine leukemia virus

1983 • 201 citations

Retrovirus-induced murine acquired immunodeficiency syndrome: natural history of infection and differing susceptibility of inbred mouse strains

1989 • 200 citations

Requirement for Cotolerogenic Gene Products in the Clonal Deletion of I-E Reactive T Cells

1990 • 193 citations

Helper T-cell antigenic site identification in the acquired immunodeficiency syndrome virus gp120 envelope protein and induction of immunity in mice to the native protein using a 16-residue synthetic peptide.

1987 • 175 citations

Binding of staphylococcal enterotoxin A to HLA-DR on B cell lines.

1989 • 169 citations

Prevention and treatment of murine experimental allergic encephalomyelitis with T cell receptor V beta-specific antibodies.

1990 • 164 citations

Evolution of B cell lineage lymphomas in mice with a retrovirus-induced immunodeficiency syndrome, MAIDS.

1988 • 162 citations

CD4+ T cells are required for development of a murine retrovirus-induced immunodeficiency syndrome (MAIDS).

1988 • 147 citations

Antigenic peptides recognized by T lymphocytes from AIDS viral envelope-immune humans

1988 • 146 citations

Preferential expression of the T-cell receptor Vβ3 gene by Mlsc reactive T cells

1988 • 123 citations

T cell recognition of HIV synthetic peptides in a natural infection.

1989 • 119 citations

Characteristics of B cell proliferation and activation in murine AIDS.

1989 • 118 citations

The T cell receptor Vβ6 domain imparts reactivity to the Mls-1a antigen

1989 • 114 citations

Postnatal disappearance of self-reactive (V beta 6+) cells from the thymus of Mlsa mice. Implications for T cell development and autoimmunity.

1989 • 108 citations

B cells are required for induction of T cell abnormalities in a murine retrovirus-induced immunodeficiency syndrome.

1990 • 106 citations

Abrogation of resistance to severe mousepox in C57BL/6 mice infected with LP-BM5 murine leukemia viruses

1987 • 97 citations

Immunodeficiency and Clonal Growth of Target Cells Induced by Helper-Free Defective Retrovirus

1989 • 94 citations

Functional and phenotypic alterations in T cell subsets during the course of MAIDS, a murine retrovirus-induced immunodeficiency syndrome.

1989 • 93 citations

The immunobiology of the T cell response to Mls-locus-disparate stimulator cells. I. Unidirectionality, new strain combinations, and the role of Ia antigens.

1985 • 85 citations

Stimulation of mouse lymphocytes by a mitogen derived from Mycoplasma arthritidis (MAM). VIII. Selective activation of T cells expressing distinct V beta T cell receptors from various strains of mice by the "superantigen" MAM.

1990 • 70 citations

T lymphocyte responses to Mls locus antigens involve recognition of H-2 I region gene products

1977 • 65 citations

Relative V beta transcript levels in thymus and peripheral lymphoid tissues from various mouse strains. Inverse correlation of I-E and Mls expression with relative abundance of several V beta transcripts in peripheral lymphoid tissues.

1989 • 65 citations

Immunoregulatory activities of human immunodeficiency virus (HIV) proteins: effect of HIV recombinant and synthetic peptides on immunoglobulin synthesis and proliferative responses by normal lymphocytes.

1988 • 60 citations

H-2-associated and background genes influence the development of a murine retrovirus-induced immunodeficiency syndrome.

1990 • 59 citations

Aberrant expression of cytokine genes in peritoneal macrophages from mice infected with LP-BM5 MuLV, a murine model of AIDS.

1991 • 58 citations

Characterization of the gag/fusion protein encoded by the defective Duplan retrovirus inducing murine acquired immunodeficiency syndrome

1990 • 48 citations

Stimulation of mouse lymphocytes by a mitogen derived from Mycoplasma arthritidis. VII. Responsiveness is associated with expression of a product(s) of the V beta 8 gene family present on the T cell receptor alpha/beta for antigen.

1989 • 44 citations

Expression of defective virus and cytokine genes in murine AIDS

1991 • 43 citations

Expression of the V beta 5.1 gene by murine peripheral T cells is controlled by MHC genes and skewed to the CD8+ subset.

1990 • 40 citations

Priming of CD4+ T cells specific for conserved regions of human immunodeficiency virus glycoprotein gp120 in humans immunized with a recombinant envelope protein.

1990 • 38 citations

Susceptibility to a mouse acquired immunodeficiency syndrome is influenced by theH-2

1989 • 37 citations

Characteristics of the cell populations involved in extra-thymic lymphosarcoma induced in C57BL/6 mice by RadLV-Rs

1981 • 37 citations

Abnormal regulation of IFN-alpha, -beta, and -gamma expression in MAIDS, a murine retrovirus-induced immunodeficiency syndrome.

1988 • 35 citations

Mls is not a single gene, allelic system. Different stimulatory Mls determinants are the products of at least two nonallelic, unlinked genes.

1987 • 35 citations

AN EXTERNAL STIMULUS THAT MIMICS Mls LOCUS RESPONSES

1988 • 34 citations

Molecular requirements for T cell activation by the staphylococcal toxic shock syndrome toxin-1.

1990 • 30 citations

The use of transfected fibroblasts and transgenic mice establishes that stimulation of T cells by the Mycoplasma arthritidis mitogen is mediated by E alpha.

1990 • 29 citations

CD4⁺ T cells in murine acquired immunodeficiency syndrome: Evidence for an intrinsic defect in the proliferative response to soluble antigen

1990 • 28 citations

Lymphocyte proliferative responses to soluble and liposome-conjugated envelope peptides of HIV-1.

1990 • 28 citations

The MIs system

1988 • 27 citations

Recognition of HIV glycoprotein gp120 by T cells. Role of monocyte CD4 in the presentation of gp120.

1989 • 24 citations

In vivo immunologic deficits in mice with murine acquired immunodeficiency syndrome and the effect of LP-BM5 infection on rejection of skin from infected mice.

1991 • 11 citations