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Deconstructing Schizophrenia: An Overview of the Use of Endophenotypes in Order to Understand a Complex Disorder

Data up to Jan 2025

Published2006
Citations457
References94

Total Citations Per Year

Abstract

References (94)

Statistical Power Analysis for the Behavioral Sciences

1989 • 83,906 citations

Statistical power analysis for the behavioral sciences

1990 • 65,781 citations

Inference of Population Structure Using Multilocus Genotype Data

2000 • 32,000 citations

The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions

2003 • 5,516 citations

Genetic Dissection of Complex Traits

1994 • 3,497 citations

Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia

2001 • 2,408 citations

Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies

2001 • 1,695 citations

Neuregulin 1 and Susceptibility to Schizophrenia

2002 • 1,654 citations

Disruption of two novel genes by a translocation co-segregating with schizophrenia

2000 • 1,250 citations

Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus

1997 • 1,142 citations

Schizophrenia and genetics : a twin study vantage point

1972 • 727 citations

Fundamentals of Genetic Epidemiology

1993 • 691 citations

Dopamine, schizophrenia, mania, and depression: Toward a unified hypothesis of cortico-striatopallido-thalamic function

1987 • 682 citations

Cognitive Deficits in Unaffected First-Degree Relatives of Schizophrenia Patients: A Meta-analytic Review of Putative Endophenotypes

2005 • 681 citations

A polygenic theory of schizophrenia.

1967 • 622 citations

Neurophysiological Endophenotypes of Schizophrenia: The Viability of Selected Candidate Measures

2006 • 567 citations

Association of Neuregulin 1 with Schizophrenia Confirmed in a Scottish Population

2003 • 557 citations

Extreme Discordant Sib Pairs for Mapping Quantitative Trait Loci in Humans

1995 • 532 citations

Proof-of-Concept Trial of an α7 Nicotinic Agonist in Schizophrenia

2006 • 529 citations

Location of a Major Susceptibility Locus for Familial Schizophrenia on Chromosome 1q21-q22

2000 • 528 citations

Basic Methods for Sensitivity Analysis of Biases

1996 • 519 citations

Toward Constructing an Endophenotype Strategy for Bipolar Disorders

2006 • 423 citations

The Stages of Mania

1973 • 415 citations

Deficits in Sensory Gating in Schizophrenic Patients and Their Relatives

1984 • 381 citations

The Consortium on the Genetics of Schizophrenia: Neurocognitive Endophenotypes

2006 • 378 citations

Association Between a Functional Catechol O-Methyltransferase Gene Polymorphism and Schizophrenia: Meta-Analysis of Case-Control and Family-Based Studies

2003 • 348 citations

Association of DISC1/TRAX Haplotypes With Schizophrenia, Reduced Prefrontal Gray Matter, and Impaired Short- and Long-term Memory

2005 • 344 citations

Psychiatric genetics: search for phenotypes

1998 • 334 citations

Cell biology of the hippocampal formation in schizophrenia

1999 • 324 citations

Mouse genetic models for prepulse inhibition: an early review

2002 • 286 citations

Replication of Linkage Studies of Complex Traits: An Examination of Variation in Location Estimates

1999 • 282 citations

A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22

2001 • 278 citations

Poor P50 Suppression Among Schizophrenia Patients and Their First-Degree Biological Relatives

1998 • 272 citations

Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: A diagnostic efficiency analysis.

1995 • 271 citations

Selective α 7 -nicotinic agonists normalize inhibition of auditory response in DBA mice

1998 • 268 citations

Endophenotypes in bipolar disorder†

2002 • 267 citations

Sensory gating deficits in schizophrenia: new results

1992 • 263 citations

Genetic Analysis of an Inherited Predisposition to Colon Cancer in a Family with a Variable Number of Adenomatous Polyps

1990 • 254 citations

12 Variance component methods for detecting complex trait loci

2001 • 238 citations

Endophenotypes for psychiatric disorders: ready for primetime?

2006 • 209 citations

Normal P50 Suppression in Schizophrenia Patients Treated With Atypical Antipsychotic Medications

2000 • 209 citations

Relationship of Obstetric Complications and Differences in Size of Brain Structures in Monozygotic Twin Pairs Discordant for Schizophrenia

2000 • 207 citations

Gating of auditory P50 in schizophrenics: Unique effects of clozapine

1996 • 203 citations

Epigenetics and twins: three variations on the theme

2006 • 194 citations

Mapping quantitative trait loci with extreme discordant sib pairs: sampling considerations.

1996 • 176 citations

Colorectal cancer: a model for epigenetic tumorigenesis

2006 • 176 citations

Effects of typical and atypical antipsychotics on prepulse inhibition in schizophrenia: a critical evaluation of current evidence and directions for future research

2002 • 173 citations

P50 Suppression among schizophrenia and normal comparison subjects: A methodological analysis

1997 • 169 citations

Linkage analysis of quantitative traits: increased power by using selected samples.

1991 • 167 citations

The Consortium on the Genetics of Endophenotypes in Schizophrenia: Model Recruitment, Assessment, and Endophenotyping Methods for a Multisite Collaboration

2006 • 161 citations

Diagnostic accuracy and linkage analysis: how useful are schizophrenia spectrum phenotypes?

1995 • 160 citations

Recent Advances in the Neurobiology of Schizophrenia

2003 • 155 citations

NURR1 Mutations in cases of schizophrenia and manic-depressive disorder

2000 • 146 citations

Anxiety proneness linked to epistatic loci in genome scan of human personality traits

1998 • 145 citations

Further investigation of a chromosome 15 locus in schizophrenia: Analysis of affected sibpairs from the NIMH genetics initiative

1998 • 129 citations

Genetics of Chromosome 15q13-q14 in Schizophrenia

2006 • 129 citations

Search for schizophrenia susceptibility genes

2000 • 125 citations

Multiple site evaluation of P50 suppression among schizophrenia and normal comparison subjects

1998 • 114 citations

Methods for Conducting Sensitivity Analysis of Trials with Potentially Nonignorable Competing Causes of Censoring

2001 • 111 citations

Basic Methods for Sensitivity Analysis of Biases

1996 • 103 citations

Auditory P50 in Schizophrenics on Clozapine: Improved Gating Parallels Clinical Improvement and Changes in Plasma 3-Methoxy-4-Hydroxyphenylglycol

1999 • 103 citations

14 The future of genetic case-control studies

2001 • 102 citations

Prepulse inhibition of the startle response in risperidone-treated patients: comparison with typical antipsychotics

2002 • 100 citations

The Power to Detect Linkage Disequilibrium with Quantitative Traits in Selected Samples

2001 • 97 citations

No Association Between Schizophrenia and Polymorphisms in COMT in Two Large Samples

2005 • 97 citations

Fundamentals of Genetic Epidemiology

1994 • 91 citations

Prepulse Inhibition and P50 Suppression Are Both Deficient but not Correlated in Schizophrenia Patients

2006 • 90 citations

Genetic analysis of idiopathic hemochromatosis using both qualitative (disease status) and quantitative (serum iron) information.

1985 • 89 citations

Combining extremely concordant sibpairs with extremely discordant sibpairs provides a cost effective way to linkage analysis of quantitative trait loci

1996 • 85 citations

The inheritance of intermediate phenotypes for schizophrenia

2005 • 84 citations

Neonatal excitotoxic ventral hippocampal damage alters dopamine response to mild repeated stress and to chronic haloperidol

1995 • 83 citations

Defects in auditory sensory gating and their apparent compensation in relatives of schizophrenics

1988 • 82 citations

Improved P50 Auditory Gating With Ondansetron in Medicated Schizophrenia Patients

2005 • 82 citations

Psychiatry in the Genomics Era

2003 • 77 citations

Quantitative trait locus mapping using human pedigrees.

2000 • 77 citations

P50 Sensory Gating in Multiplex Schizophrenia Families From a Pacific Island Isolate

2002 • 71 citations

Power of variance component linkage analysis to detect epistasis

1997 • 50 citations

Effects of pergolide on sensorimotor gating of the startle reflex in rats

2001 • 46 citations

Variance-components QTL linkage analysis of selected and non-normal samples: Conditioning on trait values

2000 • 45 citations

Sensory gating of auditory evoked potentials in rats: effects of repetitive stimulation and the interstimulus interval

2001 • 44 citations

Ascertainment issues in variance components models

2000 • 43 citations

A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22

2001 • 42 citations

Ascertainment issues in variance components models

2000 • 39 citations

The NIMH perspective: next steps in schizophrenia research

2000 • 35 citations

21 Genome partitioning and whole-genome analysis

2001 • 30 citations

Statistical Genetics Concepts and Approaches in Schizophrenia and Related Neuropsychiatric Research

2006 • 27 citations

Trade-Off between Sibship Size and Sampling Scheme for Detecting Quantitative Trait Loci

1997 • 22 citations

Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: A diagnostic efficiency analysis.

1995 • 21 citations

Inverse Relationship of Perinatal Complications and Eye Tracking Dysfunction in Relatives of Patients With Schizophrenia: Evidence for a Two-Factor Model

1998 • 15 citations

Power of variance component linkage analysis to detect epistasis

1997 • 9 citations

Detection of major genes underlying several quantitative traits associated with a common disease using different ascertainment schemes

1997 • 8 citations

Sampling strategies for model free linkage analyses of quantitative traits: Implications for sib pair studies of reading and spelling disabilities to minimize the total study cost

1999 • 6 citations

Useful methods for sensitivity analysis of observational studies.

1999 • 5 citations

Detection of major genes underlying several quantitative traits associated with a common disease using different ascertainment schemes

1997 • 3 citations

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