Deconstructing Schizophrenia: An Overview of the Use of Endophenotypes in Order to Understand a Complex Disorder
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References (94)
Statistical Power Analysis for the Behavioral Sciences
1989 • 83,906 citations
Statistical power analysis for the behavioral sciences
1990 • 65,781 citations
Inference of Population Structure Using Multilocus Genotype Data
2000 • 32,000 citations
The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions
2003 • 5,516 citations
Genetic Dissection of Complex Traits
1994 • 3,497 citations
Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
2001 • 2,408 citations
Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies
2001 • 1,695 citations
Neuregulin 1 and Susceptibility to Schizophrenia
2002 • 1,654 citations
Disruption of two novel genes by a translocation co-segregating with schizophrenia
2000 • 1,250 citations
Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus
1997 • 1,142 citations
Schizophrenia and genetics : a twin study vantage point
1972 • 727 citations
Fundamentals of Genetic Epidemiology
1993 • 691 citations
Dopamine, schizophrenia, mania, and depression: Toward a unified hypothesis of cortico-striatopallido-thalamic function
1987 • 682 citations
Cognitive Deficits in Unaffected First-Degree Relatives of Schizophrenia Patients: A Meta-analytic Review of Putative Endophenotypes
2005 • 681 citations
A polygenic theory of schizophrenia.
1967 • 622 citations
Neurophysiological Endophenotypes of Schizophrenia: The Viability of Selected Candidate Measures
2006 • 567 citations
Association of Neuregulin 1 with Schizophrenia Confirmed in a Scottish Population
2003 • 557 citations
Extreme Discordant Sib Pairs for Mapping Quantitative Trait Loci in Humans
1995 • 532 citations
Proof-of-Concept Trial of an α7 Nicotinic Agonist in Schizophrenia
2006 • 529 citations
Location of a Major Susceptibility Locus for Familial Schizophrenia on Chromosome 1q21-q22
2000 • 528 citations
Basic Methods for Sensitivity Analysis of Biases
1996 • 519 citations
Toward Constructing an Endophenotype Strategy for Bipolar Disorders
2006 • 423 citations
The Stages of Mania
1973 • 415 citations
Deficits in Sensory Gating in Schizophrenic Patients and Their Relatives
1984 • 381 citations
The Consortium on the Genetics of Schizophrenia: Neurocognitive Endophenotypes
2006 • 378 citations
Association Between a Functional Catechol O-Methyltransferase Gene Polymorphism and Schizophrenia: Meta-Analysis of Case-Control and Family-Based Studies
2003 • 348 citations
Association of DISC1/TRAX Haplotypes With Schizophrenia, Reduced Prefrontal Gray Matter, and Impaired Short- and Long-term Memory
2005 • 344 citations
Psychiatric genetics: search for phenotypes
1998 • 334 citations
Cell biology of the hippocampal formation in schizophrenia
1999 • 324 citations
Mouse genetic models for prepulse inhibition: an early review
2002 • 286 citations
Replication of Linkage Studies of Complex Traits: An Examination of Variation in Location Estimates
1999 • 282 citations
A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22
2001 • 278 citations
Poor P50 Suppression Among Schizophrenia Patients and Their First-Degree Biological Relatives
1998 • 272 citations
Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: A diagnostic efficiency analysis.
1995 • 271 citations
Selective α 7 -nicotinic agonists normalize inhibition of auditory response in DBA mice
1998 • 268 citations
Endophenotypes in bipolar disorder†
2002 • 267 citations
Sensory gating deficits in schizophrenia: new results
1992 • 263 citations
Genetic Analysis of an Inherited Predisposition to Colon Cancer in a Family with a Variable Number of Adenomatous Polyps
1990 • 254 citations
12 Variance component methods for detecting complex trait loci
2001 • 238 citations
Endophenotypes for psychiatric disorders: ready for primetime?
2006 • 209 citations
Normal P50 Suppression in Schizophrenia Patients Treated With Atypical Antipsychotic Medications
2000 • 209 citations
Relationship of Obstetric Complications and Differences in Size of Brain Structures in Monozygotic Twin Pairs Discordant for Schizophrenia
2000 • 207 citations
Gating of auditory P50 in schizophrenics: Unique effects of clozapine
1996 • 203 citations
Epigenetics and twins: three variations on the theme
2006 • 194 citations
Mapping quantitative trait loci with extreme discordant sib pairs: sampling considerations.
1996 • 176 citations
Colorectal cancer: a model for epigenetic tumorigenesis
2006 • 176 citations
Effects of typical and atypical antipsychotics on prepulse inhibition in schizophrenia: a critical evaluation of current evidence and directions for future research
2002 • 173 citations
P50 Suppression among schizophrenia and normal comparison subjects: A methodological analysis
1997 • 169 citations
Linkage analysis of quantitative traits: increased power by using selected samples.
1991 • 167 citations
The Consortium on the Genetics of Endophenotypes in Schizophrenia: Model Recruitment, Assessment, and Endophenotyping Methods for a Multisite Collaboration
2006 • 161 citations
Diagnostic accuracy and linkage analysis: how useful are schizophrenia spectrum phenotypes?
1995 • 160 citations
Recent Advances in the Neurobiology of Schizophrenia
2003 • 155 citations
NURR1 Mutations in cases of schizophrenia and manic-depressive disorder
2000 • 146 citations
Anxiety proneness linked to epistatic loci in genome scan of human personality traits
1998 • 145 citations
Further investigation of a chromosome 15 locus in schizophrenia: Analysis of affected sibpairs from the NIMH genetics initiative
1998 • 129 citations
Genetics of Chromosome 15q13-q14 in Schizophrenia
2006 • 129 citations
Search for schizophrenia susceptibility genes
2000 • 125 citations
Multiple site evaluation of P50 suppression among schizophrenia and normal comparison subjects
1998 • 114 citations
Methods for Conducting Sensitivity Analysis of Trials with Potentially Nonignorable Competing Causes of Censoring
2001 • 111 citations
Basic Methods for Sensitivity Analysis of Biases
1996 • 103 citations
Auditory P50 in Schizophrenics on Clozapine: Improved Gating Parallels Clinical Improvement and Changes in Plasma 3-Methoxy-4-Hydroxyphenylglycol
1999 • 103 citations
14 The future of genetic case-control studies
2001 • 102 citations
Prepulse inhibition of the startle response in risperidone-treated patients: comparison with typical antipsychotics
2002 • 100 citations
The Power to Detect Linkage Disequilibrium with Quantitative Traits in Selected Samples
2001 • 97 citations
No Association Between Schizophrenia and Polymorphisms in COMT in Two Large Samples
2005 • 97 citations
Fundamentals of Genetic Epidemiology
1994 • 91 citations
Prepulse Inhibition and P50 Suppression Are Both Deficient but not Correlated in Schizophrenia Patients
2006 • 90 citations
Genetic analysis of idiopathic hemochromatosis using both qualitative (disease status) and quantitative (serum iron) information.
1985 • 89 citations
Combining extremely concordant sibpairs with extremely discordant sibpairs provides a cost effective way to linkage analysis of quantitative trait loci
1996 • 85 citations
The inheritance of intermediate phenotypes for schizophrenia
2005 • 84 citations
Neonatal excitotoxic ventral hippocampal damage alters dopamine response to mild repeated stress and to chronic haloperidol
1995 • 83 citations
Defects in auditory sensory gating and their apparent compensation in relatives of schizophrenics
1988 • 82 citations
Improved P50 Auditory Gating With Ondansetron in Medicated Schizophrenia Patients
2005 • 82 citations
Psychiatry in the Genomics Era
2003 • 77 citations
Quantitative trait locus mapping using human pedigrees.
2000 • 77 citations
P50 Sensory Gating in Multiplex Schizophrenia Families From a Pacific Island Isolate
2002 • 71 citations
Power of variance component linkage analysis to detect epistasis
1997 • 50 citations
Effects of pergolide on sensorimotor gating of the startle reflex in rats
2001 • 46 citations
Variance-components QTL linkage analysis of selected and non-normal samples: Conditioning on trait values
2000 • 45 citations
Sensory gating of auditory evoked potentials in rats: effects of repetitive stimulation and the interstimulus interval
2001 • 44 citations
Ascertainment issues in variance components models
2000 • 43 citations
A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22
2001 • 42 citations
Ascertainment issues in variance components models
2000 • 39 citations
The NIMH perspective: next steps in schizophrenia research
2000 • 35 citations
21 Genome partitioning and whole-genome analysis
2001 • 30 citations
Statistical Genetics Concepts and Approaches in Schizophrenia and Related Neuropsychiatric Research
2006 • 27 citations
Trade-Off between Sibship Size and Sampling Scheme for Detecting Quantitative Trait Loci
1997 • 22 citations
Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: A diagnostic efficiency analysis.
1995 • 21 citations
Inverse Relationship of Perinatal Complications and Eye Tracking Dysfunction in Relatives of Patients With Schizophrenia: Evidence for a Two-Factor Model
1998 • 15 citations
Power of variance component linkage analysis to detect epistasis
1997 • 9 citations
Detection of major genes underlying several quantitative traits associated with a common disease using different ascertainment schemes
1997 • 8 citations
Sampling strategies for model free linkage analyses of quantitative traits: Implications for sib pair studies of reading and spelling disabilities to minimize the total study cost
1999 • 6 citations
Useful methods for sensitivity analysis of observational studies.
1999 • 5 citations
Detection of major genes underlying several quantitative traits associated with a common disease using different ascertainment schemes
1997 • 3 citations