C4b-Binding Protein (C4BP) Activates B Cells through the CD40 Receptor

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

2000 • 3,323 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2)

2000 • 1,604 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

1995 • 1,046 citations

X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-κB signaling

2001 • 806 citations

Mice deficient for the CD40 ligand

1994 • 753 citations

NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1999 • 526 citations

CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells.

1990 • 453 citations

Specific missense mutations in NEMO result in hyper-IgM syndrome with hypohydrotic ectodermal dysplasia

2001 • 384 citations

Mutations ofCD40gene cause an autosomal recessive form of immunodeficiency with hyper IgM

2001 • 379 citations

Mechanism and control of class-switch recombination

2002 • 379 citations

Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa B.

1994 • 358 citations

TRAF5, an Activator of NF-κB and Putative Signal Transducer for the Lymphotoxin-β Receptor

1996 • 343 citations

TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling.

1996 • 339 citations

Modulation of the classical pathway C3 convertase by plasma proteins C4 binding protein and C3b inactivator.

1979 • 338 citations

Within Germinal Centers, Isotype Switching of Immunoglobulin Genes Occurs after the Onset of Somatic Mutation

1996 • 310 citations

CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.

1994 • 245 citations

Differential activation of the ERK, JNK, and p38 mitogen-activated protein kinases by CD40 and the B cell antigen receptor.

1996 • 237 citations

Activation of the B-cell Surface Receptor CD40 Induces A20, a Novel Zinc Finger Protein That Inhibits Apoptosis

1995 • 205 citations

The CD40 ligand expressed by human B cells costimulates B cell responses.

1995 • 200 citations

Deficient natural killer cell cytotoxicity in patients with IKK-γ/NEMO mutations

2002 • 193 citations

Regulation of Immune Responses by NF-κB/Rel Transcription Factors

1998 • 193 citations

IgE in asthma and atopy: cellular and molecular connections

1999 • 191 citations

Deficient natural killer cell cytotoxicity in patients with IKK-γ/NEMO mutations

2002 • 167 citations

Novel subunit in C4b-binding protein required for protein S binding.

1988 • 151 citations

Hydrocortisone and IL-4 induce IgE isotype switching in human B cells.

1991 • 149 citations

CCP1–4 of the C4b-binding protein α-chain are required for factor I mediated cleavage of complement factor C3b

2002 • 146 citations

CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: synergy with IL-4 induction.

1997 • 136 citations

Structural Requirements for the Complement Regulatory Activities of C4BP

2001 • 133 citations

A highly variable region in members of the streptococcal M protein family binds the human complement regulator C4BP.

1996 • 129 citations

Differential Role for p38 Mitogen-Activated Protein Kinase in Regulating CD40-Induced Gene Expression in Dendritic Cells and B Cells

1999 • 126 citations

Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes

2002 • 122 citations

The Binding Site for TRAF2 and TRAF3 but Not for TRAF6 Is Essential for CD40-Mediated Immunoglobulin Class Switching

2002 • 120 citations

A Cluster of Positively Charged Amino Acids in the C4BP α-Chain Is Crucial for C4b Binding and Factor I Cofactor Function

1999 • 111 citations

Bordetella pertussis binds the human complement regulator C4BP: role of filamentous hemagglutinin

1997 • 110 citations

Protein S binding in relation to the subunit composition of human C4b‐binding protein

1989 • 95 citations

Independent association of serum amyloid P component, protein S, and complement C4b with complement C4b-binding protein and subsequent association of the complex with membranes.

1990 • 89 citations

Degradation of human complement component C4b in the presence of the C4b-binding protein-protein S complex

1983 • 80 citations

Molecular control of B Lymphocyte growth and differentiation

1994 • 77 citations

Localization in situ of the co‐stimulatory molecules B7.1, B7.2, CD40 and their ligands in normal human lymphoid tissue

1995 • 77 citations

Serum Amyloid P Component Binding to C4b-binding Protein

1995 • 71 citations

Opposing roles of CD95 (Fas/APO-1) and CD40 in the death and rescue of human low density tonsillar B cells.

1995 • 70 citations

Deletions in the ligand for CD40 in X-linked immunoglobulin deficiency with normal or elevated IgM (HIGMX-1)

1993 • 67 citations

The localization of heparin-binding fragments on human C4b-binding protein.

1990 • 66 citations

Role of cytokines in the early stages of chronic colitis in TCR alpha-mutant mice.

1997 • 61 citations

A Novel Interaction Between Type IV Pili ofNeisseria gonorrhoeaeand the Human Complement Regulator C4b-Binding Protein

2001 • 61 citations

CD40-CD154 Interactions in B-Cell Signaling

2000 • 61 citations

Structural Requirements for the Intracellular Subunit Polymerization of the Complement Inhibitor C4b-Binding Protein

2002 • 59 citations

Isoforms of human C4b-binding protein. II. Differential modulation of the C4BPA and C4BPB genes by acute phase cytokines.

1995 • 58 citations

Somatic mutation of human immunoglobulin V genes in the X-linked HyperIgM syndrome.

1995 • 56 citations

Signals delivered via MHC class II molecules synergize with signals delivered via TCR/CD3 to cause proliferation and cytokine gene expression in T cells.

1992 • 54 citations

Independent regulation of c-myc, B-myb, and c-myb gene expression by inducers and inhibitors of proliferation in human B lymphocytes.

1992 • 51 citations

Human genes for the alpha and beta chains of complement C4b-binding protein are closely linked in a head-to-tail arrangement.

1990 • 46 citations

Murine C4b-binding protein. Mapping of the ligand binding site and the N-terminus of the pre-protein.

1993 • 43 citations

Molecular Pathology of X-Linked Immunoglobulin Deficiency with Normal or Elevated IgM (HIGMX-1)

1994 • 43 citations

Interferon-induced transcriptional and post-transcriptional modulation of factor H and C4 binding-protein synthesis in human monocytes

1990 • 43 citations

Analysis of the promoter elements necessary for IL-4 and anti-CD40 antibody induction of murine Fc epsilon RII (CD23): comparison with the germline epsilon promoter.

1997 • 41 citations

Regulation of C4b-binding protein gene expression by the acute-phase mediators tumor necrosis factor-.alpha., interleukin-6, and interleukin-1

1992 • 38 citations

Epitope‐dependent synergism and antagonism between CD40 antibodies and soluble CD40 ligand for the regulation of CD23 expression and IgE synthesis in human B cells

1999 • 26 citations

CD40-mediated p38 mitogen-activated protein kinase activation is required for immunoglobulin class switch recombination to IgE

2002 • 24 citations

Characterization of a 23-kDa protein associated with CD40.

1995 • 23 citations

CD40 Employs p38 MAP Kinase in IgE Isotype Switching

2001 • 19 citations

Evidence that C4b-binding protein (proline-rich protein) is synthesized by hepatocytes

1991 • 17 citations

Pig apolipoprotein R: A new member of the short consensus repeat family of proteins

1992 • 15 citations

Quantifiable analysis of human immunoglobulin heavy chain class-switch recombination to all isotypes

2000 • 11 citations