Structural Requirements for the Complement Regulatory Activities of C4BP

Modulation of the classical pathway C3 convertase by plasma proteins C4 binding protein and C3b inactivator.

1979 • 338 citations

Purification of human C4b-binding protein and formation of its complex with vitamin K-dependent protein S

1983 • 285 citations

Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis.

1988 • 274 citations

Human C4-binding protein. I. Isolation and characterization

1978 • 263 citations

Mapping of the complement regulatory domains in the human factor H-like protein 1 and in factor H1.

1995 • 260 citations

Identification of complement regulatory domains in human factor H.

1995 • 250 citations

Three-dimensional structure of a complement control protein module in solution

1991 • 242 citations

Each of the Three Binding Sites on Complement Factor H Interacts with a Distinct Site on C3b

2000 • 222 citations

Visualization of human C4b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C4b.

1983 • 221 citations

Binding of C4b-Binding Protein to Porin

2001 • 209 citations

The unactivated form of the first component of human complement, C1

1976 • 190 citations

Mapping of the domains required for decay acceleration activity of the human factor H-like protein 1 and factor H

1996 • 167 citations

Novel subunit in C4b-binding protein required for protein S binding.

1988 • 151 citations

Contribution of the repeating domains of membrane cofactor protein (CD46) of the complement system to ligand binding and cofactor activity.

1991 • 143 citations

Diversity of Sites for Measles Virus Binding and for Inactivation of Complement C3b and C4b on Membrane Cofactor Protein CD46

1995 • 132 citations

Sites within the complement C3b/C4b receptor important for the specificity of ligand binding.

1991 • 127 citations

Localization of the complement-component-C3b-binding site and the cofactor activity for factor I in the 38kDa tryptic fragment of factor H

1984 • 115 citations

A Cluster of Positively Charged Amino Acids in the C4BP α-Chain Is Crucial for C4b Binding and Factor I Cofactor Function

1999 • 111 citations

Bordetella pertussis binds the human complement regulator C4BP: role of filamentous hemagglutinin

1997 • 110 citations

Localization of classical and alternative pathway regulatory activity within the decay-accelerating factor.

1996 • 107 citations

Purification of the human complement control protein C3b inactivator

1980 • 98 citations

Identification of multiple sites of interaction between heparin and the complement system

1993 • 96 citations

Analysis of the functional domains of complement receptor type 1 (C3b/C4b receptor; CD35) by substitution mutagenesis.

1994 • 95 citations

Complement activation and inhibition in experimental models of arthritis

1999 • 93 citations

Structure-Function Analysis of the Active Sites of Complement Receptor Type 1

1998 • 89 citations

Functional domains, structural variations and pathogen interactions of MCP, DAF and CR1

2000 • 87 citations

Human C4b-Binding Protein Has Overlapping, But Not Identical, Binding Sites for C4b and Streptococcal M Proteins

2000 • 82 citations

Degradation of human complement component C4b in the presence of the C4b-binding protein-protein S complex

1983 • 80 citations

Binding of human complement component C4b-binding protein (C4BP) to Streptococcus pyogenes involves the C4b-binding site.

1996 • 77 citations

Characterization of the interaction of human C4b-binding protein with physiological ligands.

1984 • 75 citations

The amino-terminal module of the C4b-binding protein α-chain is crucial for C4b binding and factor I-cofactor function

1997 • 69 citations

Soluble complement receptor one (sCR1) inhibits the development and progression of rat collagen-induced arthritis

2000 • 60 citations

Ultrastructure of C4b-binding protein fragments formed by limited proteolysis using chymotrypsin.

1984 • 58 citations

cDNA structure of murine C4b-binding protein, a regulatory component of the serum complement system

1987 • 51 citations

Structural investigation of C4b-binding protein by molecular modeling: Localization of putative binding sites

1998 • 48 citations

Limited Chymotryptic Cleavage of Human C4-Binding Protein: Isolation of a Carbohydrate-Containing Core Domain and an Active Fragment1

1982 • 44 citations

Murine C4b-binding protein. Mapping of the ligand binding site and the N-terminus of the pre-protein.

1993 • 43 citations

Interaction of C4-binding protein with cell-bound C4b. A quantitative analysis of binding and the role of C4-binding protein in proteolysis of cell-bound C4b.

1983 • 41 citations

Positively charged amino acids at the interface between α-chain CCP1 and CCP2 of C4BP are required for regulation of the classical C3-convertase

2000 • 35 citations

Structural and functional studies on C4b-binding protein, a regulatory component of the human complement system

1985 • 34 citations

Inhibition of complement components C3 and C4 by cadralazine and its active metabolite

1991 • 30 citations

Characterization of functional properties of C4-binding protein by monoclonal antibodies.

1985 • 27 citations

The region Ser³³³‐Arg³⁵⁶ of the α‐chain of human C4b‐binding protein is involved in the binding of complement C4b

1993 • 18 citations

A monomeric human C4b-binding protein (C4bp) more efficiently inactivates C3b than natural C4bp: Participation of C-terminal domains in factor I-cofactor activity

1998 • 13 citations