Molecular Pathology of X-Linked Immunoglobulin Deficiency with Normal or Elevated IgM (HIGMX-1)

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins

1990 • 977 citations

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

1993 • 840 citations

CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome

1993 • 836 citations

A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells.

1992 • 818 citations

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

1993 • 769 citations

Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

1993 • 739 citations

CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

1993 • 719 citations

Induction of human IgE synthesis in B cells by mast cells and basophils

1993 • 662 citations

Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease

1992 • 654 citations

Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal.

1993 • 622 citations

CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40.

1993 • 593 citations

Long-Term Human B Cell Lines Dependent on Interleukin-4 and antibody to CD40

1991 • 554 citations

A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.

1989 • 527 citations

The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity.

1992 • 518 citations

Prevention of Collagen-Induced Arthritis with an Antibody to gp39, the Ligand for CD40

1993 • 471 citations

CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells.

1990 • 453 citations

Germinal center cells express bcl‐2 protein after activation by signals which prevent their entry into apoptosis

1991 • 446 citations

Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50.

1986 • 439 citations

Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion.

1992 • 409 citations

The distinct surface of human blood dendritic cells, as observed after an improved isolation method.

1990 • 402 citations

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.

1993 • 393 citations

The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells.

1993 • 384 citations

Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM.

1993 • 372 citations

Identification of a novel surface protein on activated CD4+ T cells that induces contact-dependent B cell differentiation (help).

1992 • 357 citations

In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39.

1993 • 354 citations

Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens.

1989 • 331 citations

Immunodeficiency with hyper-IgM (HIM).

1992 • 318 citations

Cloning of TRAP, a ligand for CD40 on human T cells

1992 • 280 citations

Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation.

1993 • 261 citations

CD40 is functionally expressed on human thymic epithelial cells.

1992 • 261 citations

IL-13 induces proliferation and differentiation of human B cells activated by the CD40 ligand

1993 • 260 citations

In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate T-B cell interactions.

1993 • 250 citations

Activation of human B lymphocytes through CD40 and interleukin 4

1989 • 227 citations

Immunoglobulin Class Switching: Molecular and Cellular Analysis

1990 • 224 citations

Isolation and characterization of human tonsil dendritic cells.

1988 • 201 citations

RECURRENT BACTERIAL INFECTIONS AND DYSGAMMAGLOBULINEMIA: DEFICIENCY OF 7S GAMMA-GLOBULINS IN THE PRESENCE OF ELEVATED 19S GAMMA-GLOBULINS

1961 • 185 citations

Suppression of apoptosis in normal and neoplastic human B lymphocytes by CD40 ligand is independent of Bcl‐2 induction

1993 • 180 citations

A p50 surface antigen restricted to human urinary bladder carcinomas and B lymphocytes

1985 • 169 citations

A 3-D model for the CD40 ligand predicts that it is a compact trimer similar to the tumor necrosis factors

1993 • 168 citations

IgE secretion by Epstein-Barr virus-infected purified human B lymphocytes is stimulated by interleukin 4 and suppressed by interferon gamma.

1989 • 167 citations

Regulation of expression of the ligand for CD40 on T helper lymphocytes.

1993 • 155 citations

Soluble forms of CD40 inhibit biologic responses of human B cells.

1992 • 154 citations

Hydrocortisone and IL-4 induce IgE isotype switching in human B cells.

1991 • 149 citations

Rescue from anti-IgM-induced programmed cell death by the B cell surface proteins CD20 and CD40

1992 • 142 citations

Augmentation of normal and malignant B cell proliferation by monoclonal antibody to the B cell-specific antigen BP50 (CDW40).

1987 • 141 citations

Stimulation of protein tyrosine phosphorylation, phosphoinositide turnover, and multiple previously unidentified serine/threonine-specific protein kinases by the Pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B-cell ontogeny.

1991 • 139 citations

Resting B lymphocytes can be triggered directly through the CDw40 (Bp50) antigen. A comparison with IL-4-mediated signaling.

1988 • 136 citations

Temporal association of CD40 antigen expression with discrete stages of human B-cell ontogeny and the efficacy of anti-CD40 immunotoxins against clonogenic B-lineage acute lymphoblastic leukemia as well as B- lineage non-Hodgkin's lymphoma cells

1990 • 129 citations

Evidence for a Defect in Switch T Cells in Patients with Immunodeficiency and Hyperimmunoglobulinemia M

1986 • 126 citations

Human B cell precursors proliferate and express CD23 after CD40 ligation.

1993 • 123 citations

CD40 ligand is a T cell growth factor

1993 • 123 citations

Regulation of IgE synthesis in humans: A tale of two signals

1991 • 103 citations

Induction by anti‐CD40 antibody or soluble CD40 ligand and cytokines of IgG, IgA and IgE production by B cells from patients with X‐linked hyper IgM syndrome

1993 • 96 citations

Hyper Immunoglobulin M Immunodeficiency (Dysgammaglobulinemia)

1979 • 88 citations

Hyper IgM immunodeficiency. A primary dysfunction of B lymphocyte isotype switching.

1983 • 80 citations

Induction of germ-line and mature C epsilon transcripts in human B cells stimulated with rIL-4 and EBV.

1990 • 77 citations

Human b-cell differentiation. I. Analysis of immunoglobulin heavy chain switching using monoclonal anti-immunoglobulin M, G, and A antibodies and pokeweed mitogen-induced plasma cell differentiation.

1982 • 75 citations

Deletional switch recombination occurs in interleukin-4-induced isotype switching to IgE expression by human B cells.

1991 • 74 citations

Role of CD40-CD40-ligand interaction in Ig-isotype switching

1993 • 69 citations

Deletions in the ligand for CD40 in X-linked immunoglobulin deficiency with normal or elevated IgM (HIGMX-1)

1993 • 67 citations

Dysgammaglobulinemia in the Adult Manifested as Autoimmune Hemolytic Anemia

1963 • 66 citations

Biochemical characteristics and partial amino acid sequence of the receptor-like human B cell and carcinoma antigen CDw40.

1989 • 64 citations

Genomic structure and chromosomal mapping of the murine CD40 gene.

1992 • 58 citations

Close linkage of random DNA fragments from Xq 21.3–22 to X-linked agammaglobulinaemia (XLA)

1987 • 57 citations

Mapping of the x-linked form of hyper-IgM syndrome (HIGM1) to Xq26 by close linkage to HPRT

1992 • 57 citations

X-linked immunodeficiency with hyperimmunoglobulinemia M appears to be linked to the DXS42 restriction fragment length polymorphism locus

1987 • 53 citations

Evidence that in X‐linked immunodeficiency with hyperimmunoglobulinemia M the intrinsic immunoglobulin heavy chain class switch mechanism is intact

1990 • 50 citations

Acquired Dysgammaglobulinemia

1963 • 43 citations

The molecular basis for T cell help in humoral immunity: CD40 and its ligand, gp39

1993 • 41 citations

Chromosomal location of the human tumor necrosis factor receptor genes

1991 • 39 citations

Human B-lymphocyte subpopulations

1981 • 31 citations

Evidence that Pokeweed‐Mitogen‐reactive B Cells are Pre‐committed in Vivo to the High‐rate Secretion of a Single Immunoglobulin Isotype in Vitro

1981 • 30 citations

Dinucleotide repeat polymorphism in the human CD40 ligand gene

1993 • 23 citations

IgM-restricted production of immunoglobulin by lymphoid cell lines from patients with immunodeficiency with hyper IgM (dysgammaglobulinemia)

1981 • 19 citations

Chromosomal localization of the gene for human B-cell antigen CD40

1993 • 18 citations

Analysis of X-chromosome inactivation in X-linked immunodeficiency with hyper-IgM (HIGM1): evidence for involvement of different hematopoietic cell lineages

1991 • 18 citations

Mapping of the X linked form of hyper IgM syndrome (HIGM1)

1993 • 18 citations

T cell malignancy in Richter's syndrome presenting as hyper IgM. Induction and characterization of a novel CD3, CD4-, CD8 T cell subset from phytohemagglutinin-stimulated patient's CD3, CD4, CD8 leukemic T cells

1989 • 14 citations