Deficient natural killer cell cytotoxicity in patients with IKK-γ/NEMO mutations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

Activating Receptors and Coreceptors Involved in Human Natural Killer Cell-Mediated Cytolysis

2001 • 1,728 citations

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

2001 • 1,333 citations

Severe Herpesvirus Infections in an Adolescent without Natural Killer Cells

1989 • 1,251 citations

The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling

2000 • 927 citations

X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-κB signaling

2001 • 806 citations

X–linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein

1996 • 739 citations

Genomic rearrangement in NEMO impairs NF-κB activation and is a cause of incontinentia pigmenti

2000 • 714 citations

A Novel X-Linked Disorder of Immune Deficiency and Hypohidrotic Ectodermal Dysplasia Is Allelic to Incontinentia Pigmenti and Due to Mutations in IKK-gamma (NEMO)

2000 • 509 citations

CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells.

1990 • 453 citations

Mutations in the human homologue of mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasia

1999 • 393 citations

Specific missense mutations in NEMO result in hyper-IgM syndrome with hypohydrotic ectodermal dysplasia

2001 • 384 citations

An absolute and restricted requirement for IL-12 in natural killer cell IFN-gamma production and antiviral defense. Studies of natural killer and T cell responses in contrasting viral infections.

1996 • 384 citations

Gene defect in ectodermal dysplasia implicates a death domain adapter in development

2001 • 379 citations

IKKα controls formation of the epidermis independently of NF-κB

2001 • 357 citations

Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells

2000 • 348 citations

Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells

1997 • 320 citations

Pathogenesis of murine cytomegalovirus infection in natural killer cell-depleted mice

1984 • 287 citations

Clinical aspects of X-linked hypohidrotic ectodermal dysplasia.

1987 • 259 citations

A non-X-linked syndrome with susceptibility to severe epstein-barr virus infections

1982 • 143 citations

Atypical Forms of Incontinentia Pigmenti in Male Individuals Result from Mutations of a Cytosine Tract in Exon 10 of NEMO (IKK-γ)

2001 • 140 citations

Natural killer (NK) cell deficiency associated with an epitope-deficient Fc receptor type IIIA (CD16-II)

1996 • 133 citations

NK cell-mediated lysis of autologous antigen-presenting cells is triggered by the engagement of the phosphatidylinositol 3-kinase upon ligation of the natural cytotoxicity receptors NKp30 and NKp46

2001 • 131 citations

The CD40L Promoter Contains Nuclear Factor of Activated T Cells-binding Motifs Which Require AP-1 Binding for Activation of Transcription

1996 • 119 citations

IL-2-induced signal transduction involves the activation of nuclear NF-kappa B expression.

1992 • 89 citations

The Tyrosine Kinase Pyk-2/Raftk Regulates Natural Killer (Nk) Cell Cytotoxic Response, and Is Translocated and Activated upon Specific Target Cell Recognition and Killing

2000 • 87 citations

Role of IKKγ/NEMO in Assembly of the IκB Kinase Complex

2001 • 76 citations

A patient with simultaneous absence of “classical” natural killer cells (CD3−, CD16+, and NKH1+) and expansion of CD3+, CD4−, CD8−, NKH1+ subset

1990 • 71 citations

Impaired Natural Killing of MHC Class I-Deficient Targets by NK Cells Expressing a Catalytically Inactive Form of SHP-1

2000 • 65 citations

Effects of metabolic inhibitors on spontaneous and interferon-boosted human natural killer cell activity.

1980 • 64 citations

Cutting Edge: Functional Role for Proline-Rich Tyrosine Kinase 2 in NK Cell-Mediated Natural Cytotoxicity

2000 • 56 citations

Signaling for cytotoxicity

2000 • 43 citations

Role of JAK3 in CD40-Mediated Signaling

1998 • 34 citations

Cellular redox status influences both cytotoxic and NF‐κB activation in natural killer cells

1997 • 23 citations

Generation of cytotoxic NK cells in peripheral blood and bone marrow of patients with acute myelogenous leukemia after continuous infusion with recombinant interleukin‐2

1991 • 20 citations