Probing the structure‐activity relationship of Escherichia coli LT‐A by site‐directed mutagenesis

Oligonucleotide-directed mutagenesis using M13-derived vectors: an efficient and general procedure for the production of point mutations in any fragment of DNA

1982 • 764 citations

Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli

1991 • 556 citations

Sourcebook of bacterial protein toxins

1991 • 537 citations

Detection of Heat-Labile Escherichia coli Enterotoxin with the Use of Adrenal Cells in Tissue Culture

1974 • 406 citations

Amino acid sequence homology between cholera toxin and Escherichia coli heat-labile toxin

1980 • 328 citations

Intestinal Electrolyte Transport and Diarrheal Disease

1989 • 320 citations

Mutants of Pertussis Toxin Suitable for Vaccine Development

1989 • 318 citations

Refined Structure of Escherichia coli Heat-labile Enterotoxin, a Close Relative of Cholera Toxin

1993 • 299 citations

Adp‐Ribosylation of Guanyl Nucleotide‐Binding Regulatory Proteins by Bacterial Toxins

1988 • 270 citations

A Heat-Labile Enterotoxin from Strains of Escherichia coli Enteropathogenic for Pigs

1969 • 246 citations

The amino-acid sequence of two non-toxic mutants of diphtheria toxin: CRM45 and CRM197

1984 • 245 citations

Studies on Escherichia coli enterotoxin

1967 • 237 citations

Intestinal Electrolyte Transport and Diarrheal Disease

1989 • 205 citations

Investigation of the detoxification mechanism of formaldehyde-treated tetanus toxin

2007 • 189 citations

NAD binding site of diphtheria toxin: identification of a residue within the nicotinamide subsite by photochemical modification with NAD.

1984 • 150 citations

Genetics of Bacterial Enterotoxins

1986 • 149 citations

Exotoxin A of Pseudomonas aeruginosa: substitution of glutamic acid 553 with aspartic acid drastically reduces toxicity and enzymatic activity

1987 • 115 citations

Pertussis Toxin S1 Mutant with Reduced Enzyme Activity and a Conserved Protective Epitope

1988 • 113 citations

Common features of the NAD‐binding and catalytic site of ADP‐ribosylating toxins

1994 • 111 citations

Subunit S1 of pertussis toxin: mapping of the regions essential for ADP-ribosyltransferase activity.

1988 • 105 citations

Escherichia coli heat-labile enterotoxin. Nucleotide sequence of the A subunit gene.

1982 • 104 citations

Diphtheria toxin. Effect of substituting aspartic acid for glutamic acid 148 on ADP-ribosyltransferase activity.

1985 • 96 citations

Active-site mutations of diphtheria toxin: effects of replacing glutamic acid-148 with aspartic acid, glutamine, or serine

1990 • 91 citations

Sequence homologies between A subunits of Escherichia coli and Vibrio cholerae enterotoxins.

1981 • 85 citations

Effect of site-directed mutagenic alterations on ADP-ribosyltransferase activity of the A subunit of Escherichia coli heat-labile enterotoxin

1991 • 80 citations

A single amino acid substitution in the A subunit of Escherichia coli enterotoxin results in a loss of its toxic activity.

1990 • 73 citations

Computer modelling of the NAD binding site of ADP‐ribosylating toxins: active‐site structure and mechanism of NAD binding

1991 • 72 citations

Site-specific mutagenesis of the catalytic subunit of cholera toxin: substituting lysine for arginine 7 causes loss of activity

1991 • 66 citations

Evolution and structure of two ADP‐ribosylation enterotoxins, Escherichia coli heat‐labile toxin and cholera toxin

1984 • 62 citations

ADP-ribosyltransferase mutations in the catalytic S-1 subunit of pertussis toxin

1988 • 61 citations

A single amino acid substitution in the A subunit of Escherichia coli enterotoxin results in a loss of its toxic activity.

1990 • 60 citations

[23] Cholera toxin-catalyzed [32P]ADP-ribosylation of proteins

1991 • 50 citations

Inactivation of the Escherichia coli heat‐labile enterotoxin by in vitro mutagenesis of the A‐subunit gene

1989 • 44 citations

Glutamic acid‐112 of the A subunit of heat‐labile enterotoxin from enterotoxigenic Escherichia coli is important for ADP‐ribosyltransferase activity

1991 • 43 citations

The subunit S1 is important for pertussis toxin secretion.

1990 • 41 citations

Activation of cholera toxin and Escherichia coli heat‐labile enterotoxins by ADP‐ribosylation factors, a family of 20 kDa guanine nucleotide‐binding proteins

1991 • 39 citations

Alkylation of Cysteine 41, but Not Cysteine 200, Decreases the ADP-ribosytransferase Activity of the S1 Subunit of Pertussis Toxin

1989 • 37 citations

Pseudomonas aeruginosa exotoxin A: Alterations of biological and biochemical properties resulting from mutation of glutamic acid 553 to aspartic acid

1990 • 37 citations

The NAD-glycohydrolase activity of the pertussis toxin S1 subunit. Involvement of the catalytic HIS-35 residue.

1994 • 33 citations

Heat-labile enterotoxin of Escherichia coli. Characterization of different crystal forms.

1985 • 32 citations

Progress towards the development of new vaccines against whooping cough

1992 • 32 citations

Heat-labile enterotoxin of Escherichia coli. Characterization of different crystal forms.

1985 • 28 citations

ADP-ribosyl transferase activity of cholera toxin polypeptide A1 and the effect of limited trypsinolysis

1981 • 25 citations

Binding specificities of heat-labile enterotoxins isolated from porcine and human enterotoxigenic Escherichia coli for different gangliosides

1989 • 22 citations

Histidine-21 is involved in diphtheria toxin NAD+ binding

1990 • 20 citations

[21] Soluble guanine nucleotide-dependent ADP-ribosylation factors in activation of adenylyl cyclase by cholera toxin

1991 • 13 citations

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