Differential Regulation of Leptin Transport by the Choroid Plexus and Blood-Brain Barrier and High Affinity Transport Systems for Entry into Hypothalamus and Across the Blood-Cerebrospinal Fluid Barrier*

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Leptin and the regulation of body weight in mammals

1998 • 5,366 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

Leptin enters the brain by a saturable system independent of insulin

1996 • 1,210 citations

Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance

1996 • 1,170 citations

Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans

1996 • 1,004 citations

Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor

1997 • 907 citations

Localization of leptin receptor mRNA and the long form splice variant (Ob‐Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization

1996 • 879 citations

Specificity of Leptin Action on Elevated Blood Glucose Levels and Hypothalamic Neuropeptide Y Gene Expression in ob/ob Mice

1996 • 873 citations

Diet-induced obese mice develop peripheral, but not central, resistance to leptin.

1997 • 750 citations

CNS Drug Design Based on Principles of Blood‐Brain Barrier Transport

1998 • 436 citations

Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers.

1996 • 414 citations

Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels.

1997 • 374 citations

Expression of Leptin Receptor Isoforms in Rat Brain Microvessels

1998 • 342 citations

Regulation of Neuronal and Glial Proteins by Leptin: Implications for Brain Development*

1999 • 320 citations

Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation.

1999 • 249 citations

Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer.

1998 • 232 citations

Phenotype of the Obese Koletsky (f) Rat Due to Tyr763Stop Mutation in the Extracellular Domain of the Leptin Receptor (Lepr): Evidence for Deficient Plasma-to-CSF Transport of Leptin in Both the Zucker and Koletsky Obese Rat

1997 • 221 citations

Leptin Receptor Long-form Splice-variant Protein Expression in Neuron Cell Bodies of the Brain and Co-localization with Neuropeptide Y mRNA in the Arcuate Nucleus

1999 • 204 citations

Bioavailability and Transport of Peptides and Peptide Drugs into the Brain

1997 • 147 citations

Differential Expression and Regulation of Leptin Receptor Isoforms in the Rat Brain: Effects of Fasting and Oestrogen

1998 • 141 citations

Subcellular Localization and Internalization of the Four Human Leptin Receptor Isoforms

1999 • 139 citations

Cerebrovascular permeability to peptides: manipulations of transport systems at the blood-brain barrier.

1995 • 128 citations

OB protein binds specifically to the choroid plexus of mice and rats.

1996 • 124 citations

Fate of Leptin after Intracerebroventricular Injection into the Mouse Brain

1998 • 116 citations

Leptin in Anorexia Nervosa¹

1998 • 106 citations

Autoradiographic Localization of Leptin Binding in the Choroid Plexus ofob/obanddb/dbMice

1996 • 102 citations

Disruption of the Relationship between Fat Content and Leptin Levels with Aging in Humans¹

1998 • 102 citations

Up‐Regulation of Blood‐Brain Barrier Short‐Form Leptin Receptor Gene Products in Rats Fed a High Fat Diet

1998 • 96 citations

Micronutrient Homeostasis in Mammalian Brain and Cerebrospinal Fluid

1989 • 90 citations

Disruption of the Relationship between Fat Content and Leptin Levels with Aging in Humans

1998 • 80 citations

Functional Properties of Leptin Receptor Isoforms Containing the Gln→Pro Extracellular Domain Mutation of the Fatty Rat*

1998 • 76 citations

Leptin in Anorexia Nervosa

1998 • 70 citations

Leptin binding in the arcuate nucleus is increased during fasting

1999 • 65 citations

Acidosis, Acetazolamide, and Amiloride: Effects on²²Na Transfer Across the Blood-Brain and Blood-CSF Barriers

1989 • 62 citations

Efficacy of exogenous recombinant murine leptin in lean and obese 10- to 12-mo-old female CD-1 mice

1998 • 60 citations

Ultrastructural Immunolocalization of Leptin Receptor in Mouse Brain

1998 • 59 citations

Determinants of Serum Leptin Levels in Cushing’s Syndrome

1998 • 58 citations

Circulating leptin has saturable transport into intrathecal space in humans

1998 • 53 citations

Na(+)-H+ exchange in choroid plexus and CSF in acute metabolic acidosis or alkalosis

1990 • 47 citations

Leptin, a Pleiotropic Hormone: Physiology, Pharmacology, and Strategies for Discovery of Leptin Modulators

1998 • 43 citations

Regional localization of specific [125I]leptin binding sites in rat forebrain

1998 • 27 citations

Determinants of Serum Leptin Levels in Cushing's Syndrome

1998 • 27 citations

Kinetics of circulating vasopressin uptake by choroid plexus

1991 • 23 citations

Arachnoid membrane, subarachnoid CSF and pia–glia

1998 • 19 citations