Dissociation of peripheral T cell responses from thymocyte negative selection by weak agonists supports a spare receptor model of T cell activation

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

A MODIFICATION OF RECEPTOR THEORY

1956 • 1,126 citations

Kinetic proofreading in T-cell receptor signal transduction.

1995 • 931 citations

Altered Peptide Ligand–Induced Partial T Cell Activation: Molecular Mechanisms and Role in T Cell Biology

1996 • 698 citations

Evidence for a differential avidity model of T cell selection in the thymus

1994 • 679 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

Positive Selection of Thymocytes

1995 • 604 citations

Structure of the p53 Tumor Suppressor Bound to the Ankyrin and SH3 Domains of 53BP2

1996 • 569 citations

COMPARISON OF DISSOCIATION CONSTANTS AND OF RELATIVE EFFICACIES OF SELECTED AGONISTS ACTING ON PARASYMPATHETIC RECEPTORS*

1967 • 517 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

1990 • 468 citations

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness.

1994 • 431 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

Low avidity recognition of self-antigen by T cells permits escape from central tolerance

1995 • 415 citations

Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands

1993 • 414 citations

The Minimal Number of Class II MHC-Antigen Complexes Needed for T Cell Activation

1990 • 410 citations

Structures of an MHC Class II Molecule with Covalently Bound Single Peptides

1996 • 369 citations

High- and Low-Potency Ligands with Similar Affinities for the TCR

1998 • 322 citations

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

2001 • 314 citations

Enhanced Antigen-Specific Antitumor Immunity with Altered Peptide Ligands that Stabilize the MHC-Peptide-TCR Complex

2000 • 312 citations

T cell receptor antagonists and partial agonists

1995 • 303 citations

Kinetic discrimination in T-cell activation.

1996 • 286 citations

Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes

1994 • 253 citations

Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells

1991 • 249 citations

A differential-avidity model for T-cell selection

1994 • 239 citations

How Much TCR Does a T Cell Need?

2001 • 224 citations

The major histocompatibility complex-restricted antigen receptor on T cells: Distribution on thymus and peripheral T cells

1984 • 210 citations

Preselection Thymocytes Are More Sensitive to T Cell Receptor Stimulation Than Mature T Cells

1998 • 208 citations

Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II.

1995 • 186 citations

Use of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93-103).

1994 • 185 citations

Divergent Changes in the Sensitivity of Maturing T Cells to Structurally Related Ligands Underlies Formation of a Useful T Cell Repertoire

1999 • 176 citations

Peptides in positive and negative selection: A delicate balance

1994 • 153 citations

Complete dissection of the Hb(64-76) determinant using T helper 1, T helper 2 clones, and T cell hybridomas.

1992 • 131 citations

Several Different Cell Surface Molecules Control Negative Selection of Medullary Thymocytes

1999 • 127 citations

Receptor Mechanisms

1964 • 107 citations

Quantitative Analysis of the T Cell Repertoire that Escapes Negative Selection

1999 • 103 citations

Correlation Between the Number of T Cell Receptors Required for T Cell Activation and TCR–Ligand Affinity

1996 • 103 citations

Modulation of the Major Histocompatibility Complex Class II–Associated Peptide Repertoire by Human Histocompatibility Leukocyte Antigen (Hla)-Do

2000 • 89 citations

Negative selection of CD4+ CD8+ thymocytes by T-cell receptor peptide antagonists.

1994 • 88 citations

A peptide antigen antagonist prevents the differentiation of T cell receptor transgenic thymocytes.

1994 • 86 citations

Lowering the tone: mechanisms of immunodominance among epitopes with low affinity for MHC

1996 • 74 citations

T cell positive selection by a high density, low affinity ligand

1998 • 69 citations

Differential TCR Signaling Regulates Apoptosis and Immunopathology during Antigen Responses In Vivo

1998 • 63 citations

Kinetics of the reactions between the invariant chain (85–99) peptide and proteins of the murine class II MHC

1995 • 55 citations

Kinetics of Peptide Binding to the Class II MHC Protein I−E^k

2000 • 53 citations

Costimulatory signals are required for induction of transcription factor Nur77 during negative selection of CD4⁺CD8⁺thymocytes

1999 • 35 citations

Antigen processing: HLA-DO – a hitchhiking inhibitor of HLA-DM

1998 • 34 citations

Cellular and biochemical requirements for thymocyte negative selection

1996 • 32 citations