Long-Term Treatment of Bile Duct-Ligated Rats with Rapamycin (Sirolimus) Significantly Attenuates Liver Fibrosis: Analysis of the Underlying Mechanisms

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

TOR, a Central Controller of Cell Growth

2000 • 1,919 citations

RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1994 • 1,470 citations

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

1998 • 1,319 citations

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

1999 • 1,255 citations

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

1994 • 903 citations

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1998 • 872 citations

Translational Control of p27 ^Kip1 Accumulation During the Cell Cycle

1996 • 864 citations

Stimulation of Fibroblast Cell Growth, Matrix Production, and Granulation Tissue Formation by Connective Tissue Growth Factor

1996 • 754 citations

Retinoblastoma protein switches the E2F site from positive to negative element

1992 • 663 citations

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

2000 • 587 citations

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

1998 • 579 citations

Connective Tissue Growth Factor: What's in a Name?

2000 • 483 citations

Cytokines and Fibrogenesis

1999 • 358 citations

Expression of connective tissue growth factor in experimental rat and human liver fibrosis

1999 • 326 citations

Immunopurified Mammalian Target of Rapamycin Phosphorylates and Activates p70 S6 Kinase α in Vitro

1999 • 325 citations

Rapamycin Resistance Tied to Defective Regulation of p27^Kip1

1996 • 213 citations

Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis

1999 • 211 citations

Mechanism of action of rapamycin: New insights into the regulation of G1-phase progression in eukaryotic cells

1995 • 166 citations

Proliferating Bile Duct Epithelial Cells Are a Major Source of Connective Tissue Growth Factor in Rat Biliary Fibrosis

2001 • 148 citations

The evolution of changes in quantitative liver function tests in a rat model of biliary cirrhosis: Correlation with morphometric measurement of hepatocyte mass

1987 • 146 citations

Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression

2003 • 145 citations

Rapamycin inhibition of interleukin-2-dependent p33cdk2 and p34cdc2 kinase activation in T lymphocytes.

1993 • 143 citations

Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells

2000 • 138 citations

Expression of platelet-derived growth factor in newly formed cholangiocytes during experimental biliary fibrosis in rats

1999 • 128 citations

Expression of G1-S modulators (p53, p16, p27, cyclin D1, Rb) and Smad4/Dpc4 in intrahepatic cholangiocarcinoma

2002 • 113 citations

Mitogenic signals for platelet-derived growth factor isoforms in liver fat-storing cells

1991 • 112 citations

Rapamycin Potentiates Transforming Growth Factor β-Induced Growth Arrest in Nontransformed, Oncogene-Transformed, and Human Cancer Cells

2002 • 103 citations

Sirolimus increases transforming growth factor-β1 expression and potentiates chronic cyclosporine nephrotoxicity

2004 • 89 citations

Rapamycin-insensitive Regulation of 4E-BP1 in Regenerating Rat Liver

2001 • 82 citations

Splanchnic hemodynamics in portal-hypertensive rats: measurement with gamma-labeled microspheres

1982 • 78 citations

FK506 binding protein 12 mediates sensitivity to both FK506 and rapamycin in murine mast cells

1995 • 74 citations

MECHANISM OF THE COMBINATION IMMUNOSUPPRESSIVE EFFECTS OF RAPAMYCIN WITH EITHER CYCLOSPORINE OR TACROLIMUS

2000 • 71 citations

Regulation and role of p21 and p27 cyclin-dependent kinase inhibitors during hepatocyte differentiation and growth

2003 • 65 citations

Establishment of an Immortalized Human Hepatic Stellate Cell Line to Develop Antifibrotic Therapies

2003 • 58 citations

Overexpression of endothelin-1 in bile duct ligated rats: correlation with activation of hepatic stellate cells and portal pressure

2001 • 44 citations

Rapamycin inhibits cdk4 activation, p 21^WAF1/CIP1 expression and G1‐phase progression in transformed mouse fibroblasts

2003 • 40 citations

The Translational Cis ‐Regulatory Element of Mammalian Ribosomal Protein mRNAs is Recognized by the Plant Translational Apparatus

1996 • 39 citations

MAMMALIAN TARGET OF RAPAMYCIN AND 3-PHOSPHATIDYLINOSITOL 3-KINASE PATHWAY INHIBITION ENHANCES GROWTH INHIBITION OF TRANSFORMING GROWTH FACTOR-β1 IN PROSTATE CANCER CELLS

2004 • 36 citations

Characterisation of portal hypertension models by microspheres in anaesthetised rats: a comparison of liver flow

2001 • 33 citations

Leucine, Glutamine, and Tyrosine Reciprocally Modulate the Translation Initiation Factors eIF4F and eIF2B in Perfused Rat Liver

1999 • 32 citations

Adenoviral-mediated transfer of p53 or retinoblastoma protein blocks cell proliferation and induces apoptosis in culture-activated hepatic stellate cells

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Effect of development on the functional and histological changes induced by bile-duct ligation in the rat

1994 • 28 citations

Vasodilator mRNA levels are increased in the livers of portal hypertensive NO‐synthase 3‐deficient mice

2004 • 26 citations

Liver cell dysplasia: reactivities for c-met protein, Rb protein, E-cadherin and transforming growth factor-beta 1 in comparison with hepatocellular carcinoma.

1998 • 19 citations

Immunomodulation in stable renal transplant recipients with concomitant tacrolimus and sirolimus therapy.

2002 • 10 citations

Activity of aminopeptidase M, dipeptidylpeptidase IV and g-glutamyltransferase in the gallbladder mucosa of donors for organ transplantation

2001 • 2 citations