Rapamycin Potentiates Transforming Growth Factor β-Induced Growth Arrest in Nontransformed, Oncogene-Transformed, and Human Cancer Cells

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1994 • 1,954 citations

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

1991 • 1,937 citations

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1998 • 1,763 citations

Mice Lacking p27 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors

1996 • 1,583 citations

RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1994 • 1,470 citations

MYC oncogenes and human neoplastic disease

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2001 • 981 citations

Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

1997 • 953 citations

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

1994 • 903 citations

Blocking Oncogenic Ras Signaling for Cancer Therapy

2001 • 837 citations

An Assay for Transforming Growth Factor-β Using Cells Transfected with a Plasminogen Activator Inhibitor-1 Promoter-Luciferase Construct

1994 • 749 citations

TGF-β1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains

1990 • 612 citations

Suppression of Tumorigenicity of Human Prostate Carcinoma Cells by Replacing a Mutated RB Gene

1990 • 606 citations

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1998 • 510 citations

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2001 • 479 citations

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Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F

1997 • 468 citations

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1999 • 427 citations

mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer.

2001 • 421 citations

Integrin β1 Signaling Is Necessary for Transforming Growth Factor-β Activation of p38MAPK and Epithelial Plasticity

2001 • 381 citations

The Immunophilin FKBP12 Functions as a Common Inhibitor of the TGFβ Family Type I Receptors

1996 • 370 citations

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1997 • 357 citations

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Rapamycin Inhibition of the G1 to S Transition Is Mediated by Effects on Cyclin D1 mRNA and Protein Stability

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2000 • 337 citations

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1995 • 292 citations

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1993 • 283 citations

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1989 • 283 citations

c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover

2000 • 276 citations

Inhibition of the Phosphoinositide 3-Kinase Pathway Induces a Senescence-like Arrest Mediated by p27Kip1

2000 • 273 citations

Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy.

2001 • 263 citations

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1995 • 253 citations

A role for transcriptional repression of p21 ^CIP1 by c-Myc in overcoming transforming growth factor β-induced cell-cycle arrest

2000 • 249 citations

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2000 • 248 citations

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1995 • 244 citations

c-myc Is a Downstream Target of the Smad Pathway

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1995 • 237 citations

Role of transforming growth factor beta in cancer

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Myc Downregulation by Transforming Growth Factor β Required for Activation of the p15^Ink4b G₁ Arrest Pathway

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Direct Interaction of c-Myc with Smad2 and Smad3 to Inhibit TGF-β-Mediated Induction of the CDK Inhibitor p15Ink4B

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1994 • 202 citations

Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor beta receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene.

1997 • 195 citations

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Translational induction of the c-myc oncogene via activation of the FRAP/TOR signalling pathway

1998 • 177 citations

Studies on the Mechanism of Resistance to Rapamycin in Human Cancer Cells

1998 • 173 citations

FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse

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1995 • 164 citations

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Transforming growth factor ? regulation of cell proliferation

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TGFβ in prostate cancer: A growth inhibitor that can enhance tumorigenicity

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A Link between Increased Transforming Activity of Lymphoma-Derived MYC Mutant Alleles, Their Defective Regulation by p107, and Altered Phosphorylation of the c-Myc Transactivation Domain

1995 • 142 citations

Transforming growth factors and control of neoplastic cell growth

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Expression of Dominant-Negative Mutant DP-1 Blocks Cell Cycle Progression in G₁

1996 • 139 citations

FKBP12, the 12-kDa FK506-binding protein, is a physiologic regulator of the cell cycle

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Association Between the T29→C Polymorphism in the Transforming Growth Factor β1 Gene and Breast Cancer Among Elderly White Women

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1995 • 131 citations

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Factor-binding element in the human c-myc promoter involved in transcriptional regulation by transforming growth factor beta 1 and by the retinoblastoma gene product.

1991 • 120 citations

p130 and p107 Use a Conserved Domain To Inhibit Cellular Cyclin-Dependent Kinase Activity†

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Characterization of the Interaction of FKBP12 with the Transforming Growth Factor-β Type I Receptor in Vivo

1996 • 85 citations

TGF-β1 effects on proliferation of rat intestinal epithelial cells are due to inhibition of cyclin D1 expression

1998 • 83 citations

Salicylate-induced Growth Arrest Is Associated with Inhibition of p70s6k and Down-regulation of c-Myc, Cyclin D1, Cyclin A, and Proliferating Cell Nuclear Antigen

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Transforming growth factor beta 1 regulation of c-myc expression, pRB phosphorylation, and cell cycle progression in keratinocytes.

1992 • 81 citations

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1993 • 69 citations

NF-κB is required for H-ras oncogene induced abnormal cell proliferation and tumorigenesis

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Alterations of the retinoblastoma gene in human prostate adenocarcinoma

1996 • 67 citations

Three distinct elements within the murine c-myc promoter are required for transcription.

1992 • 62 citations

Disruption of TGF-β growth inhibition by oncogenic ras is linked to p27Kip1 mislocalization

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A role for a p21-E2F interaction during senescence arrest of normal human fibroblasts.

1996 • 59 citations

E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor β through E2F binding sites

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Inhibition of DNA Synthesis by a Farnesyltransferase Inhibitor Involves Inhibition of the p70s6k Pathway

1999 • 46 citations

TGF-β-signaling with small molecule FKBP12 antagonists that bind myristoylated FKBP12-TGF-β type I receptor fusion proteins

1998 • 37 citations

Transforming growth factor-β receptors on human endometrial cells: identification of the type I, II, and III receptors and glycosylphosphatidylinositol anchored TGF-β binding proteins

1995 • 35 citations

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The effect of H-ras oncogene transfection on response of mink lung epithelial cells to growth factors and cytotoxic drugs.

1991 • 9 citations