Mitogenic signals for platelet-derived growth factor isoforms in liver fat-storing cells

PLATELET-DERIVED GROWTH FACTOR

1989 • 967 citations

cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

1986 • 786 citations

Signal Transduction by the Platelet-Derived Growth Factor Receptor

1989 • 653 citations

Interleukin-1 Mitogenic Activity for Fibroblasts and Smooth Muscle Cells Is Due to PDGF-AA

1989 • 648 citations

Isolation of a Novel Receptor cDNA Establishes the Existence of Two PDGF Receptor Genes

1989 • 610 citations

Two Classes of PDGF Receptor Eecognize Different Isoforms of PDGF

1988 • 603 citations

Role of Phosphatidylinositol Kinase in PDGF Receptor Signal Transduction

1989 • 516 citations

Cultured endothelial cells produce a platelet-derived growth factor-like protein

1983 • 507 citations

cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor.

1989 • 413 citations

Isolation and culture of hepatic lipocytes, Kupffer cells, and sinusoidal endothelial cells by density gradient centrifugation with Stractan

1987 • 359 citations

Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-gamma in quiescent BALB/c 3T3 cells.

1989 • 262 citations

Suramin binds to platelet‐derived growth factor and inhibits its biological activity

1985 • 257 citations

Platelet-derived growth factor synthesis in mesangial cells: induction by multiple peptide mitogens.

1989 • 240 citations

Platelet-derived growth factor (PDGF) binding promotes physical association of PDGF receptor with phospholipase C.

1989 • 235 citations

Platelet isoforms of platelet-derived growth factor stimulate fibroblasts to contract collagen matrices.

1989 • 224 citations

Sera and conditioned media contain different isoforms of platelet-derived growth factor (PDGF) which bind to different classes of PDGF receptor

1989 • 216 citations

Expression and developmental control of platelet-derived growth factor A-chain and B-chain/Sis genes in rat aortic smooth muscle cells.

1988 • 214 citations

Isoform-specific induction of actin reorganization by platelet-derived growth factor suggests that the functionally active receptor is a dimer.

1989 • 191 citations

Blockade of autocrine stimulation in simian sarcoma virus-transformed cells reverses down-regulation of platelet-derived growth factor receptors.

1984 • 163 citations

Ca2+-channel blockers inhibit the action of recombinant platelet-derived growth factor in vascular smooth muscle cells.

1989 • 138 citations

Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways.

1989 • 137 citations

Expression of Three Recombinant Homodimeric Isoforms of PDGF inSaccharomyces cerevisiae: Evidence for Difference in Receptor Binding and Functional Activities

1989 • 126 citations

Autocrine mechanism for v-sis transformation requires cell surface localization of internally activated growth factor receptors.

1989 • 112 citations

Production of platelet-derived growth factorlike protein by rat mesangial cells in culture.

1987 • 110 citations

Both homodimeric isoforms of PDGF (AA and BB) have mitogenic and chemotactic activity and stimulate phosphoinositol turnover

1989 • 78 citations

Localization of a chemotactic domain in human thrombin

1984 • 75 citations