The mechanism of action of methotrexate in cultured L5178Y leukemia cells.

A simple efficient liquid scintillator for counting aqueous solutions in a liquid scintillation counter

1960 • 7,610 citations

EVALUATION OF THE TRYPAN BLUE TECHNIQUE FOR DETERMINATION OF CELL VIABILITY

1964 • 718 citations

STUDIES ON UNBALANCED GROWTH IN ESCHERICHIA COLI

1954 • 406 citations

Studies on unbalanced growth in tissue culture. I. Induction and consequences of thymidine deficiency.

1960 • 340 citations

The incorporation of 3H-cytosine arabinoside and its effect on murine leukemic cells (L5178Y)

1968 • 296 citations

Threshold Methotrexate Concentration for In Vivo Inhibition of DNA Synthesis in Normal and Tumorous Target Tissues

1973 • 240 citations

Treatment of leukemia with large doses of methotrexate and folinic acid: clinical-biochemical correlates

1969 • 234 citations

Direct Spectrophotometric Evidence for the Oxidation of Tetrahydrofolate during the Enzymatic Synthesis of Thymidylate

1961 • 209 citations

THE BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ACTION AND EFFECTS OF THE FOLIC ACID ANTAGONISTS.

1963 • 156 citations

Cell killing studies on the mode of action of methotrexate on L-cells in vitro.

1969 • 132 citations

DEVELOPMENT, MAINTENANCE AND ASSAY OF DRUG RESISTANCE.

1964 • 108 citations

Purineless death as a link between growth rate and cytotoxicity by methotrexate.

1972 • 77 citations

S-phase cells of rapidly growing and resting populations. Differences in response to methotrexate.

1969 • 70 citations

Studies relating to the mode of action of methotrexate. 3. Inhibition of thymidylate synthetase in tissue culture cells and in cell-free systems.

1969 • 56 citations

Differential cell permeability and the basis for selective activity of methotrexate during therapy of the L1210 leukemia.

1973 • 42 citations

Effects of methotrexate and cytosine arabinoside on polyamine metabolism in a mouse L1210 leukemia.

1972 • 23 citations

Current studies of the folate antagonists in patients with acute leukemia.

1965 • 12 citations

Rationale for the selection of chemotherapeutic agents.

1969 • 8 citations

Clinical correlates of in vitro effect of methotrexate on acute leukemia blasts.

1974 • 7 citations