Drug Absorption Interactions Between Oral Targeted Anticancer Agents and PPIs: Is pH-Dependent Solubility the Achilles Heel of Targeted Therapy?

Membrane transporters in drug development

2010 • 3,093 citations

Predicting Drug Disposition via Application of BCS: Transport/Absorption/ Elimination Interplay and Development of a Biopharmaceutics Drug Disposition Classification System

2005 • 1,348 citations

Predicting in vivo drug interactions from in vitro drug discovery data

2005 • 842 citations

A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants

2006 • 713 citations

BDDCS Applied to Over 900 Drugs

2011 • 585 citations

Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption

2007 • 409 citations

Pharmacokinetic variability of anticancer agents

2005 • 241 citations

Pharmacokinetics of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Locally Advanced or Metastatic Solid Tumors: the Role of Alpha-1-Acid Glycoprotein Binding

2011 • 116 citations

Introduction to computational oral absorption simulation

2009 • 115 citations

Clinical impact of CYP2C19 polymorphism on the action of proton pump inhibitors: a review of a special problem

2007 • 104 citations

Phase I Study of the Effect of Gastric Acid pH Modulators on the Bioavailability of Oral Dasatinib in Healthy Subjects

2009 • 95 citations

Acid−Base Profiling of Imatinib (Gleevec) and Its Fragments

2004 • 94 citations

A Multicenter Phase II Study of Erlotinib and Sorafenib in Chemotherapy-Naïve Patients with Advanced Non–Small Cell Lung Cancer

2010 • 84 citations

Effect of the Proton Pump Inhibitor Esomeprazole on the Oral Absorption and Pharmacokinetics of Nilotinib

2010 • 81 citations

Fraction of a dose absorbed estimation for structurally diverse low solubility compounds

2010 • 67 citations

Pharmacokinetics of gefitinib in humans: The influence of gastrointestinal factors

2007 • 63 citations

Effect of a proton pump inhibitor on the pharmacokinetics of imatinib

2009 • 60 citations

A Single Dose Mass Balance Study of the Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Humans Using Accelerator Mass Spectrometry

2011 • 53 citations

Physiologic considerations in drug absorption from the gastrointestinal tract

1986 • 50 citations

Effect of antacid on imatinib absorption

2008 • 49 citations

Management of sorafenib, sunitinib, and temsirolimus toxicity in metastatic renal cell carcinoma

2009 • 48 citations

Natural history, management and pharmacokinetics of Everolimus-induced-oral ulcers: Insights into compliance issues

2011 • 43 citations

Importance of Characterizing Determinants of Variability in Exposure: Application to Dasatinib in Subjects With Chronic Myeloid Leukemia

2008 • 41 citations

Computational oral absorption simulation of free base drugs

2010 • 40 citations

The FDA Should Eliminate the Ambiguities in the Current BCS Biowaiver Guidance and Make Public the Drugs for Which BCS Biowaivers Have Been Granted

2010 • 39 citations