BDDCS Applied to Over 900 Drugs

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1

2001 • 16,438 citations

Goodman and Gilman's the Pharmacological Basis of Therapeutics

1986 • 6,964 citations

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability.

1995 • 5,050 citations

Drug-like properties and the causes of poor solubility and poor permeability

2000 • 3,405 citations

Goodman and Gilman's The Pharmacological Basis of Therapeutics

1996 • 2,325 citations

Predicting Drug Disposition via Application of BCS: Transport/Absorption/ Elimination Interplay and Development of a Biopharmaceutics Drug Disposition Classification System

2005 • 1,348 citations

Waiver of In Vivo Bioavailability and Bioequivalence Studies for Immediate-Release Solid Oral Dosage Forms Based on a Biopharmaceutics Classification System

2001 • 786 citations

Calculating log Poct from structures

1993 • 687 citations

Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 1. Prediction of intestinal absorption

1999 • 569 citations

A Provisional Biopharmaceutical Classification of the Top 200 Oral Drug Products in the United States, Great Britain, Spain, and Japan

2006 • 565 citations

Molecular fields in quantitative structure–permeation relationships: the VolSurf approach

2000 • 550 citations

Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure–activity relationship (QSAR) with the Abraham descriptors

2001 • 496 citations

Drug, Meal and Formulation Interactions Influencing Drug Absorption After Oral Administration

1999 • 489 citations

Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption

2007 • 409 citations

The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs

2009 • 404 citations

Effect of OATP1B Transporter Inhibition on the Pharmacokinetics of Atorvastatin in Healthy Volunteers

2006 • 315 citations

Aqueous solubilities of some variously substituted quinolone antimicrobials

1990 • 284 citations

The “High Solubility” Definition of the Current FDA Guidance on Biopharmaceutical Classification System May Be Too Strict for Acidic Drugs

2004 • 280 citations

Intestinal permeability and its relevance for absorption and elimination

2007 • 270 citations

A Physiological Model for the Estimation of the Fraction Dose Absorbed in Humans

2004 • 219 citations

Improved method for estimating water solubility from octanol/water partition coefficient

1996 • 218 citations

Computing chemistry on the web

2005 • 199 citations

The Drug Transporter−Metabolism Alliance: Uncovering and Defining the Interplay

2009 • 198 citations

Warfarin sensitivity related to CYP2C9, CYP3A5, ABCB1 (MDR1) and other factors

2003 • 193 citations

Current trends in lead discovery: are we looking for the appropriate properties?

2002 • 192 citations

Transporter-Enzyme Interactions: Implications for Predicting Drug-Drug Interactions from In Vitro Data

2003 • 183 citations

Quantitative Biopharmaceutics Classification System: The Central Role of Dose/Solubility Ratio

2003 • 178 citations

Chris Lipinski discusses life and chemistry after the Rule of Five

2003 • 162 citations

Multiple Transporters Affect the Disposition of Atorvastatin and Its Two Active Hydroxy Metabolites: Application of in Vitro and ex Situ Systems

2005 • 141 citations

Systems chemical biology

2007 • 139 citations

The Use of BDDCS in Classifying the Permeability of Marketed Drugs

2008 • 137 citations

Elucidating Rifampin's Inducing and Inhibiting Effects on Glyburide Pharmacokinetics and Blood Glucose in Healthy Volunteers: Unmasking the Differential Effects of Enzyme Induction and Transporter Inhibition for a Drug and Its Primary Metabolite

2008 • 122 citations

Associating Drugs, Targets and Clinical Outcomes into an Integrated Network Affords a New Platform for Computer‐Aided Drug Repurposing

2011 • 120 citations

Predicting Drug Disposition via Application of a Biopharmaceutics Drug Disposition Classification System

2010 • 108 citations

PHARMACOKINETICS OF ATORVASTATIN AND ITS HYDROXY METABOLITES IN RATS AND THE EFFECTS OF CONCOMITANT RIFAMPICIN SINGLE DOSES: RELEVANCE OF FIRST-PASS EFFECT FROM HEPATIC UPTAKE TRANSPORTERS, AND INTESTINAL AND HEPATIC METABOLISM

2006 • 108 citations

Chemical biology : from small molecules to systems biology and drug design

2007 • 91 citations

The BCS, BDDCS, and Regulatory Guidances

2011 • 88 citations

Assessment of the Health Effects of Chemicals in Humans: I. QSAR Estimation of the Maximum Recommended Therapeutic Dose (MRTD) and No Effect Level (NOEL) of Organic Chemicals Based on Clinical Trial Data1

2004 • 79 citations

Identification of Biowaivers Among Class II Drugs: Theoretical Justification and Practical Examples

2004 • 77 citations

Computational Models to Assign Biopharmaceutics Drug Disposition Classification from Molecular Structure

2007 • 63 citations

DISPOSITION OF TACROLIMUS IN ISOLATED PERFUSED RAT LIVER: INFLUENCE OF TROLEANDOMYCIN, CYCLOSPORINE, AND GG918

2003 • 62 citations

Expression of LAT1 and LAT2 amino acid transporters in human and rat intestinal epithelial cells

2005 • 54 citations

The Use of Drug Metabolism for Prediction of Intestinal Permeability

2009 • 49 citations

The FDA Should Eliminate the Ambiguities in the Current BCS Biowaiver Guidance and Make Public the Drugs for Which BCS Biowaivers Have Been Granted

2010 • 39 citations

Effect of Single-Dose Rifampin on the Pharmacokinetics of Warfarin in Healthy Volunteers

2010 • 34 citations

Computational Systems Chemical Biology

2010 • 20 citations

THE PREDICTIVE NATURE OF HIGH-THROUGHPUT TOXICITY SCREENING USING A HUMAN HEPATOCYTE CELL LINE

2002 • 16 citations

Early ADME/T Predictions: Toy or Tool?

2008 • 4 citations

Deleted Work

1955 • 0 citations