Serum Signature of Hypoxia-Regulated Factors Is Associated with Progression after Induction Therapy in Head and Neck Squamous Cell Cancer

Hypoxia — a key regulatory factor in tumour growth

2002 • 4,942 citations

Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data

2000 • 2,411 citations

Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study

2005 • 908 citations

Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta analysis of chemotherapy on head and neck cancer

2001 • 702 citations

Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesis.

2001 • 545 citations

Genetic Patterns in Head and Neck Cancers That Contain or Lack Transcriptionally Active Human Papillomavirus

2004 • 406 citations

Interleukin 6 and Interleukin 8 as Potential Biomarkers for Oral Cavity and Oropharyngeal Squamous Cell Carcinoma

2004 • 402 citations

Relation of a Hypoxia Metagene Derived from Head and Neck Cancer to Prognosis of Multiple Cancers

2007 • 366 citations

Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer.

2002 • 354 citations

Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer

2002 • 343 citations

Validation and comparison of luminex multiplex cytokine analysis kits with ELISA: Determinations of a panel of nine cytokines in clinical sample culture supernatants

2005 • 305 citations

Gene Expression Differences Associated with Human Papillomavirus Status in Head and Neck Squamous Cell Carcinoma

2006 • 304 citations

Investigating hypoxic tumor physiology through gene expression patterns

2003 • 301 citations

Cross-talk between Epidermal Growth Factor Receptor and Hypoxia-inducible Factor-1α Signal Pathways Increases Resistance to Apoptosis by Up-regulating Survivin Gene Expression

2006 • 287 citations

Induction Chemotherapy and Cetuximab for Locally Advanced Squamous Cell Carcinoma of the Head and Neck: Results From a Phase II Prospective Trial

2009 • 244 citations

The Expanding Role of Systemic Therapy in Head and Neck Cancer

2004 • 213 citations

Hypoxia-regulated carbonic anhydrase-9 (CA9) relates to poor vascularization and resistance of squamous cell head and neck cancer to chemoradiotherapy.

2001 • 199 citations

Growth Regulated Oncogene-α expression by murine squamous cell carcinoma promotes tumor growth, metastasis, leukocyte infiltration and angiogenesis by a host CXC Receptor-2 dependent mechanism

2000 • 176 citations

Human Papillomavirus in HNSCC: Recognition of a Distinct Disease Type

2008 • 159 citations

Serum levels of interleukin-6 in patients with primary head and neck squamous cell carcinoma.

2005 • 153 citations

Simultaneous detection of multiple cytokines and chemokines from nonhuman primates using luminex technology

2005 • 129 citations

Early Detection of Head and Neck Cancer: Development of a Novel Screening Tool Using Multiplexed Immunobead-Based Biomarker Profiling

2007 • 122 citations

Second malignant neoplasms in patients successfully treated with multimodality treatment for advanced head and neck cancer

1984 • 112 citations

Nuclear Factor-κB–Related Serum Factors as Longitudinal Biomarkers of Response and Survival in Advanced Oropharyngeal Carcinoma

2007 • 111 citations

Identification of Patients With Head and Neck Cancer Using Serum Protein Profiles

2004 • 110 citations

End points for new agents in induction chemotherapy for locally advanced head and neck cancers

2002 • 105 citations

Tissue oxygen distribution in head and neck cancer patients

1999 • 94 citations

Cyclooxygenase regulates human oropharyngeal carcinomas via the proinflammatory cytokine IL‐6: a general role for inflammation?

2000 • 78 citations

Elevated serum vascular endothelial growth factor and decreased survival in advanced laryngeal carcinoma

2002 • 75 citations

Primary and acquired resistance to anti-EGFR targeted drugs in cancer therapy

2007 • 73 citations

Circulating levels of vascular endothelial growth factor in patients with oral squamous cell carcinoma

2002 • 53 citations

Serum Protein Profile Analysis in Patients With Head and Neck Squamous Cell Carcinoma

2006 • 35 citations

Serum Protein Profile Analysis Following Definitive Treatment in Patients With Head and Neck Squamous Cell Carcinoma

2007 • 11 citations