Rapid Breakdown of Microvascular Barriers and Subsequent Hemorrhagic Transformation After Delayed Recombinant Tissue Plasminogen Activator Treatment in a Rat Embolic Stroke Model

Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS)

1995 • 3,456 citations

Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II)

1998 • 3,417 citations

Intravenous Thrombolysis With Recombinant Tissue Plasminogen Activator for Acute Hemispheric Stroke

1995 • 2,209 citations

High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part I: Mathematical approach and statistical analysis

1996 • 1,510 citations

Effects of Matrix Metalloproteinase-9 Gene Knock-Out on the Proteolysis of Blood–Brain Barrier and White Matter Components after Cerebral Ischemia

2001 • 982 citations

MR appearance of hemorrhage in the brain.

1993 • 720 citations

Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation

1998 • 551 citations

Monocrystalline iron oxide nanocompounds (MION): Physicochemical properties

1993 • 501 citations

Involvement of Matrix Metalloproteinase in Thrombolysis-Associated Hemorrhagic Transformation After Embolic Focal Ischemia in Rats

2002 • 412 citations

Early appearance of activated matrix metalloproteinase-9 and blood–brain barrier disruption in mice after focal cerebral ischemia and reperfusion

1999 • 340 citations

Metalloproteinase Inhibition Reduces Thrombolytic (Tissue Plasminogen Activator)–Induced Hemorrhage After Thromboembolic Stroke

2000 • 337 citations

Oxygen radicals in cerebral ischemia

1992 • 332 citations

MRI Features of Intracerebral Hemorrhage Within 2 Hours From Symptom Onset

1999 • 290 citations

Increased Formation of Reactive Oxygen Species after Permanent and Reversible Middle Cerebral Artery Occlusion in the Rat

1998 • 286 citations

Ischaemic damage of brain microvessels: inherent risks for thrombolytic treatment in stroke

1998 • 257 citations

Studies on the Specific Fibrinolytic Effect of Human Extrinsic (Tissue-Type) Plasminogen Activator in Human Blood and in Various Animal Species in Vitro

1981 • 231 citations

Use of a Spectrophotometric Hemoglobin Assay to Objectively Quantify Intracerebral Hemorrhage in Mice

1997 • 196 citations

Evaluation of risk of hemorrhagic transformation in local intra-arterial thrombolysis in acute ischemic stroke by initial SPECT.

1994 • 189 citations

Reduction of Tissue Plasminogen Activator-Induced Hemorrhage and Brain Injury by Free Radical Spin Trapping after Embolic Focal Cerebral Ischemia in Rats

2000 • 176 citations

MR Detection of Hyperacute Parenchymal Hemorrhage of the Brain

1998 • 131 citations

Hemorrhagic Transformation of Cerebral Infarction – Possible Mechanisms

1999 • 109 citations

Anti-oxidants prevent focal rat brain injury as assessed by induction of heat shock proteins (HSP70, HO-1/HSP32, HSP47) following subarachnoid injections of lysed blood

1999 • 103 citations

Continuous assessment of relative cerebral blood volume in transient ischemia using steady state susceptibility‐contrast MRI

1996 • 73 citations

Pharmacological Effects of the Spin Trap Agents N -t-Butyl-Phenylnitrone (PBN) and 2,2,6,6-Tetramethylpiperidine- N -Oxyl (TEMPO) in a Rabbit Thromboembolic Stroke Model

2001 • 66 citations

Delayed rt-PA Treatment in a Rat Embolic Stroke Model: Diagnosis and Prognosis of Ischemic Injury and Hemorrhagic Transformation with Magnetic Resonance Imaging

2001 • 58 citations

Blood-Brain Barrier Disturbances After rt-PA Treatment of Thromboembolic Stroke in the Rat

1997 • 38 citations

Brain hemorrhages after rt-PA treatment of embolic stroke in spontaneously hypertensive rats

1999 • 38 citations

Bovine erythrocyte haemolysates enhance plasminogen activation by tissue-type plasminogen activator.

1997 • 2 citations

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