The Composition of the β-2 Adrenergic Receptor Oligomer Affects Its Membrane Trafficking after Ligand-Induced Endocytosis

β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor

1996 • 1,329 citations

Cloning of a Delta Opioid Receptor by Functional Expression

1992 • 1,225 citations

Heterodimerization is required for the formation of a functional GABAB receptor

1998 • 1,156 citations

A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells.

1983 • 933 citations

Differential Affinities of Visual Arrestin, βArrestin1, and βArrestin2 for G Protein-coupled Receptors Delineate Two Major Classes of Receptors

2000 • 835 citations

Regulation of Receptor Fate by Ubiquitination of Activated β ₂ -Adrenergic Receptor and β-Arrestin

2001 • 807 citations

A Peptide Derived from a β2-Adrenergic Receptor Transmembrane Domain Inhibits Both Receptor Dimerization and Activation

1996 • 758 citations

cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.

1987 • 687 citations

A kinase-regulated PDZ-domain interaction controls endocytic sorting of the β2-adrenergic receptor

1999 • 673 citations

Oligomerization of G-protein-coupled transmitter receptors

2001 • 652 citations

Detection of β ₂ -adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)

2000 • 631 citations

Role of Heteromer Formation in GABA _B Receptor Function

1999 • 545 citations

Morphine Activates Opioid Receptors without Causing Their Rapid Internalization

1996 • 536 citations

Quantitative Assessment of β1- and β2-Adrenergic Receptor Homo- and Heterodimerization by Bioluminescence Resonance Energy Transfer

2002 • 466 citations

Dynamin and β-Arrestin Reveal Distinct Mechanisms for G Protein-coupled Receptor Internalization

1996 • 450 citations

Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors.

1992 • 445 citations

Sequestration and recycling of beta 2-adrenergic receptors permit receptor resensitization.

1995 • 343 citations

Regulation of Opioid Receptor Trafficking and Morphine Tolerance by Receptor Oligomerization

2002 • 335 citations

Oligomerization of opioid receptors with beta 2-adrenergic receptors: A role in trafficking and mitogen-activated protein kinase activation

2000 • 326 citations

mu-Opioid receptor internalization: opiate drugs have differential effects on a conserved endocytic mechanism in vitro and in the mammalian brain.

1998 • 323 citations

Modulation of Postendocytic Sorting of G Protein-Coupled Receptors

2002 • 322 citations

G-protein-coupled receptors function as oligomers in vivo

2000 • 313 citations

Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)

2000 • 304 citations

Homodimerization of the β2-Adrenergic Receptor as a Prerequisite for Cell Surface Targeting

2004 • 291 citations

μ-Opioid Receptor Internalization: Opiate Drugs Have Differential Effects on a Conserved Endocytic MechanismIn Vitroand in the Mammalian Brain

1998 • 265 citations

Enhancement of membrane insertion and function in a type IIIb membrane protein following introduction of a cleavable signal peptide.

1992 • 260 citations

Distinct Dynamin-dependent and -independent Mechanisms Target Structurally Homologous Dopamine Receptors to Different Endocytic Membranes

1999 • 229 citations

Molecular mechanisms of G protein-coupled receptor desensitization and resensitization

1998 • 219 citations

Type-specific Sorting of G Protein-coupled Receptors after Endocytosis

2000 • 218 citations

Hierarchy of mechanisms involved in generating Na/K-ATPase polarity in MDCK epithelial cells.

1995 • 211 citations

Role of Clathrin-mediated Endocytosis in Agonist-induced Down-regulation of the β2-Adrenergic Receptor

1998 • 211 citations

Homo- and hetero-oligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between less closely related sequences

2002 • 207 citations

Regulation of opioid receptor activities.

1999 • 202 citations

Antagonist-dependent and -independent steps in the mechanism of adrenergic receptor internalization

1994 • 196 citations

Mechanisms of β-Adrenergic Receptor Desensitization and Resensitization

1997 • 193 citations

A Novel Endocytic Recycling Signal That Distinguishes the Membrane Trafficking of Naturally Occurring Opioid Receptors

2003 • 189 citations

Inhibition of Cell Surface Expression by Mutant Receptors Demonstrates that D2 Dopamine Receptors Exist as Oligomers in the Cell

2000 • 150 citations

Heterodimerization of V1a and V2 vasopressin receptors determines the interaction with β-arrestin and their trafficking patterns

2004 • 147 citations

Downregulation of G protein-coupled receptors

2000 • 146 citations

δ and κ Opioid Receptors Are Differentially Regulated by Dynamin-dependent Endocytosis When Activated by the Same Alkaloid Agonist

1997 • 139 citations

Binding of the β2 Adrenergic Receptor toN-Ethylmaleimide-sensitive Factor Regulates Receptor Recycling

2001 • 137 citations

Regulated Endocytosis of G-protein-coupled Receptors by a Biochemically and Functionally Distinct Subpopulation of Clathrin-coated Pits

1998 • 136 citations

A Transplantable Sorting Signal That Is Sufficient to Mediate Rapid Recycling of G Protein-coupled Receptors

2001 • 128 citations

Oligomerisation of G-protein-coupled receptors

2001 • 124 citations

Functional rescue of a constitutively desensitized β2AR through receptor dimerization

1998 • 90 citations

Homo-oligomeric Complexes of the Yeast α-Factor Pheromone Receptor Are Functional Units of Endocytosis

2000 • 69 citations

Molecular Aspects of Muscarinic Receptor Dimerization

2000 • 63 citations

Differential Sorting of Human δ-Opioid Receptors after Internalization by Peptide and Alkaloid Agonists

2003 • 59 citations

Agonist-Specific Regulation of δ-Opioid Receptor Trafficking by G Protein-Coupled Receptor Kinase and β-Arrestin

1999 • 58 citations

Role of Arrestins in G-Protein-Coupled Receptor Endocytosis

1997 • 48 citations

Biochemical Characterization of β2-Adrenergic Receptor Dimers and Oligomers

2003 • 43 citations

Heterologous Inhibition of G Protein-coupled Receptor Endocytosis Mediated by Receptor-specific Trafficking of β-Arrestins

2001 • 38 citations

Isoproterenol-initiated beta-adrenergic receptor diacytosis in cultured cells.

1992 • 34 citations