Protein kinases and protooncogenes: biochemical regulators of the eukaryotic cell cycle

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes

1971 • 1,553 citations

Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

1983 • 1,506 citations

Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

1989 • 1,237 citations

Cyclin synthesis drives the early embryonic cell cycle

1989 • 1,223 citations

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

1987 • 1,153 citations

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

1989 • 1,114 citations

Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog

1987 • 1,004 citations

cdc25+ functions as an inducer in the mitotic control of fission yeast

1986 • 973 citations

The nuclear envelope lamina is reversibly depolymerized during mitosis

1980 • 956 citations

Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2

1989 • 920 citations

Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+

1988 • 885 citations

The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis

1988 • 829 citations

Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement

1988 • 786 citations

In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase

1990 • 783 citations

Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B

1990 • 730 citations

Comparative biochemical properties of normal and activated human ras p21 protein

1984 • 713 citations

Cyclin activation of p34cdc2

1990 • 690 citations

Requirement for c-ras proteins during viral oncogene transformation

1986 • 680 citations

Cyclin is a component of maturation-promoting factor from Xenopus

1990 • 674 citations

cdc2 protein kinase is complexed with both cyclin A and B: Evidence for proteolytic inactivation of MPF

1989 • 666 citations

The c-mos proto-oncogene product is a cytostatic factor responsible for meiotic arrest in vertebrate eggs

1989 • 654 citations

Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis

1990 • 642 citations

Purification of maturation-promoting factor, an intracellular regulator of early mitotic events.

1988 • 640 citations

Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes

1988 • 617 citations

Protein phosphatases come of age

1989 • 616 citations

Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.

1984 • 607 citations

Cell cycle dynamics of an M-phase-specific cytoplasmic factor in Xenopus laevis oocytes and eggs.

1984 • 575 citations

An essential G1 function for cyclin-like proteins in yeast

1989 • 574 citations

Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors.

1987 • 567 citations

Genetic control of cell division patterns in the Drosophila embryo

1989 • 567 citations

MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B.

1989 • 550 citations

Regulation of p34cdc2 protein kinase during mitosis

1989 • 544 citations

The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity

1984 • 539 citations

cdc2 is a component of the M phase-specific histone H1 kinase: Evidence for identity with MPF

1988 • 535 citations

The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes

1986 • 534 citations

The cell cycle control gene cdc2+ of fission yeast encodes a protein kinase potentially regulated by phosphorylation

1986 • 502 citations

The fission yeast dis2+ gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases

1989 • 486 citations

Substrates for p34cdc2: In vivo veritas?

1990 • 472 citations

Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication

1990 • 460 citations

Reversible tyrosine phosphorylation of cdc2: Dephosphorylation accompanies activation during entry into mitosis

1989 • 453 citations

G1-specific cyclins of S. cerevisiae: Cell cycle periodicity, regulation by mating pheromone, and association with the p34CDC28 protein kinase

1990 • 449 citations

The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells

1989 • 439 citations

Translation of cyclin mRNA is necessary for extracts of activated Xenopus eggs to enter mitosis

1989 • 438 citations

Control of Cell Division by Very Lysine Rich Histone (F1) Phosphorylation

1974 • 429 citations

The roles of Drosophila cyclins A and B in mitotic control

1990 • 429 citations

Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C

1990 • 425 citations

A family of cyclin homologs that control the G1 phase in yeast.

1989 • 416 citations

The interaction of steroids with Rana pipiens oocytes in the induction of maturation

1971 • 400 citations

Expression and function of Drosophila cyclin a during embryonic cell cycle progression

1989 • 399 citations

The fission yeast cdc2/cdc13/suc1 protein kinase: Regulation of catalytic activity and nuclear localization

1989 • 392 citations

S Phase of the Cell Cycle

1989 • 366 citations

Purification of MPF from starfish: Identification as the H1 histone kinase p34cdc2 and a possible mechanism for its periodic activation

1989 • 366 citations

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.

1990 • 353 citations

Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinase

1990 • 344 citations

RAS proteins can induce meiosis in xenopus oocytes

1985 • 341 citations

Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+

1987 • 341 citations

The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis

1987 • 334 citations

The Product of the mos Proto-Oncogene as a Candidate "Initiator" for Oocyte Maturation

1989 • 333 citations

Fission yeast p13 blocks mitotic activation and tyrosine dephosphorylation of the Xenopus cdc2 protein kinase

1989 • 327 citations

The bimG gene of Aspergillus nidulans, required for completion of anaphase, encodes a homolog of mammalian phosphoprotein phosphatase 1

1989 • 326 citations

Purified maturation promoting factor phosphorylates pp60c-src at the sites phosphorylated during fibroblast mitosis

1989 • 319 citations

Activation at M-phase of a protein kinase encoded by a starfish homologue of the cell cycle control gene cdc2+

1988 • 314 citations

Sequence of the cell division gene CDC2 from Schizosaccharomyces pombe; patterns of splicing and homology to protein kinases

1984 • 313 citations

Cyclin is a component of the sea urchin egg M-phase specific histone H1 kinase.

1989 • 308 citations

Dephosphorylation and activation of Xenopusp34cdc2 protein kinase during the cell cycle

1989 • 300 citations

Effects of cycloheximide on a cytoplasmic factor initiating meiotic maturation in Xenopus oocytes

1975 • 294 citations

Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate

1988 • 285 citations

Specific proteolysis of the c-mos proto-oncogene product by calpain on fertilization of Xenopus eggs

1989 • 275 citations

Conservation of mitotic controls in fission and budding yeasts

1989 • 275 citations

Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2

1989 • 270 citations

Changes in protein phosphorylation accompanying maturation of Xenopus laevis oocytes

1977 • 269 citations

Mammalian growth-associated H1 histone kinase: a homolog of cdc2+/CDC28 protein kinases controlling mitotic entry in yeast and frog cells.

1989 • 265 citations

Altered phosphorylation and activation of PP60c-src during fibroblast mitosis

1988 • 249 citations

Cdc2 H1 kinase is negatively regulated by a type 2A phosphatase in the Xenopus early embryonic cell cycle: evidence from the effects of okadaic acid.

1990 • 244 citations

Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication

1989 • 242 citations

The role of cyclin B in meiosis I.

1989 • 241 citations

Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinase

1989 • 239 citations

Rous sarcoma virus transforming protein lacking myristic acid phosphorylates known polypeptide substrates without inducing transformation

1986 • 223 citations

The fission yeast cell cycle control gene cdc2: isolation of a sequence suc1 that suppresses cdc2 mutant function

1986 • 222 citations

Regulation of mitosis by cyclic accumulation of p80cdc25 mitotic inducer in fission yeast

1990 • 221 citations

Molecular cloning and characterization of the mRNA for cyclin from sea urchin eggs.

1987 • 220 citations

Regulation of MPF activity in vitro

1988 • 209 citations

Simple and Complex Cell Cycles

1989 • 192 citations

Involvement of a type 1 protein phosphatase encoded by bws1+ in fission yeast mitotic control

1989 • 188 citations

Microinjection of antisense c-mos oligonucleotides prevents meiosis II in the maturing mouse egg.

1989 • 182 citations

Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe.

1990 • 181 citations

Mouse Mos protooncogene product is present and functions during oogenesis.

1989 • 173 citations

Cell cycle control genes in fission yeast and mammalian cells

1988 • 168 citations

Differential Phosphorylation of c-Abl in Cell Cycle Determined by cdc 2 Kinase and Phosphatase Activity

1990 • 157 citations

Meiotic maturation of mouse oocytes In Vitro: inhibition of maturation at specific stages of nuclear progression

1976 • 156 citations

Activation of M-phase-specific histone H1 kinase by modification of the phosphorylation of its p34cdc2 and cyclin components.

1990 • 150 citations

Regulation of amphibian oocyte maturation

1985 • 148 citations

Involvement of protein phosphatases 1 and 2A in the control of M phase-promoting factor activity in starfish.

1989 • 141 citations

Control of programmed cyclin destruction in a cell-free system.

1989 • 138 citations

The p53 nuclear localisation signal is structurally linked to a p34cdc2 kinase motif.

1990 • 135 citations

Mitosis-specific phosphorylation causes 83K non-muscle caldesmon to dissociate from microfilaments

1990 • 130 citations

Cell cycle oscillation of phosphatase inhibitor-2 in rat fibroblasts coincident with p34cdc2 restriction

1990 • 120 citations

Transcripts of one of two Drosophila cyclin genes become localized in pole cells during embryogenesis

1989 • 120 citations

Putting it on and taking it off: Phosphoprotein phosphatase involvement in cell cycle regulation

1989 • 119 citations

The transforming protein of Moloney murine sarcoma virus is a soluble cytoplasmic protein

1983 • 109 citations

The cyclin B2 component of MPF is a substrate for the c-mosxe proto-oncogene product

1990 • 105 citations

The heptad repeat in the largest subunit of RNA polymerase II binds by intercalating into DNA

1990 • 103 citations

Xenopus homolog of the mos protooncogene transforms mammalian fibroblasts and induces maturation of Xenopus oocytes.

1989 • 91 citations

Metaphase protein phosphorylation in Xenopus laevis eggs.

1987 • 90 citations

Protein phosphatase-1 is involved in Xenopus oocyte maturation

1981 • 86 citations

Microinjection of pp60v-src into Xenopus oocytes increases phosphorylation of ribosomal protein S6 and accelerates the rate of progesterone-induced meiotic maturation.

1984 • 86 citations

A purified complex from Xenopus oocytes contains a p47 protein, an in vivo substrate of MPF, and a p30 protein respectively homologous to elongation factors EF‐1γ and EF‐1β

1989 • 76 citations

Properties of a cytostatic factor from Xenopus laevis eggs

1979 • 67 citations

Ha-rasVal-12,Thr-59 activates S6 kinase and p34cdc2 kinase in Xenopus oocytes: evidence for c-mosxe-dependent and -independent pathways.

1990 • 66 citations

Characterization of MPF activation by okadaic acid in Xenopus oocyte

1990 • 63 citations

Monoclonal antibodies specific for thiophosphorylated proteins recognize Xenopus MPF

1988 • 62 citations

Effects of the v-mos oncogene on Xenopus development: meiotic induction in oocytes and mitotic arrest in cleaving embryos.

1990 • 57 citations

Stabilization and enhancement of primary cytostatic factor (CSF) by ATP and NaF in amphibian egg cytosols

1988 • 52 citations

Phosphorylation of histone H1 through the cell cycle of Physarum polycephalum. 24 sites of phosphorylation at metaphase.

1985 • 39 citations

In vivo actions of protein phosphatase inhibitor‐2 inXenopusoocytes

1982 • 34 citations

Fractionation of cytostatic factors from cytosols of amphibian eggs

1989 • 11 citations