Radiosensitization by fluorodeoxyuridine: effects of thymidylate synthase inhibition and cell synchronization.

The linear-quadratic formula and progress in fractionated radiotherapy

1989 • 2,150 citations

Effective Surgical Adjuvant Therapy for High-Risk Rectal Carcinoma

1991 • 1,888 citations

New Human Tumor Cell Lines

1975 • 974 citations

A method to measure the duration of DNA syntheses and the potential doubling time from a single sample

1985 • 599 citations

A clinical-pharmacological evaluation of hepatic arterial infusions of 5-fluoro-2'-deoxyuridine and 5-fluorouracil.

1978 • 516 citations

Cyclic X-Ray Responses in Mammalian Cellsin Vitro¹

2012 • 505 citations

The radioresponsiveness of human tumours and the initial slope ofthe cell survival curve

1984 • 472 citations

Studies on fluorinated pyrimidines. II. Effects on transplanted tumors.

1958 • 436 citations

Metabolism and mechanism of action of 5-fluorouracil

1990 • 431 citations

Pharmacologic requirements for obtaining sensitization of human tumor cells in vitro to combined 5-fluorouracil or ftorafur and X rays

1982 • 391 citations

Concomitant chemoradiotherapy: rationale and clinical experience in patients with solid tumors.

1990 • 370 citations

In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas.

1982 • 254 citations

Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death.

1987 • 251 citations

Control of thymidine kinase mRNA during the cell cycle.

1987 • 176 citations

Computer Programs for the Analysis of Cellular Survival Data

1987 • 171 citations

An improved method for the immunocytochemical detection of bromodeoxyuridine labeled nuclei using flow cytometry

1987 • 157 citations

The Roles of Transport and Phosphorylation in Nutrient Uptake in Cultured Animal Cells

1980 • 119 citations

Initial Slope of Radiation Survival Curves Is Characteristic of the Origin of Primary and Established Cultures of Human Tumor Cells and Fibroblasts

1987 • 118 citations

Present status of radiation therapy in the conservative management of rectal cancer

1990 • 106 citations

Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells.

1988 • 96 citations

Enhancement of mammalian cell killing by 5-fluorouracil in combination with X-rays.

1979 • 90 citations

Fluorodeoxyuridine-induced radiosensitization and inhibition of DNA double strand break repair in human colon cancer cells

1990 • 86 citations

Role of thymidine in biochemical modulation: a review.

1987 • 79 citations

Tumour shrinkage and down staging after preoperative radiation of rectal adenocarcinomas

1990 • 77 citations

Assay of intracellular free and macromolecular-bound metabolites of 5-fluorodeoxyuridine and 5-fluorouracil.

1979 • 60 citations

5-fluorouracil infusions and fractionated doses of radiation: Studies with a murine squamous cell carcinoma

1987 • 50 citations

Induction of megabase DNA fragments by 5-fluorodeoxyuridine in human colorectal tumor (HT29) cells.

1991 • 42 citations

Comparative DNA strand breakage induced by FUra and FdUrd in human ileocecal adenocarcinoma (HCT-8) cells: relevance to cell growth inhibition.

1991 • 32 citations

Dynamcis of the thymidine triphosphate pool during the cell cycle of synchronized 3T3 mouse fibroblasts

1988 • 32 citations

Combined 5‐fluorouracil (5‐FU) and radiation therapy following resection of locally advanced gastric carcinoma

1986 • 30 citations

Cell cycle related studies on thymidine kinase and its isoenzymes in Ehrlich ascites tumours

1991 • 29 citations

Inhibition of DNA excision repair by methotrexate in Chinese hamster ovary cells following exposure to ultraviolet irradiation or ethylmethanesulfonate.

1990 • 25 citations

Synchronisation of cancer cell lines of human origin using methotrexate

1990 • 23 citations

Transitional cell carcinoma of the urinary bladder: histologic clearance with combined 5-FU chemotherapy and radiation therapy. Preliminary results of a bladder-preservation study.

1988 • 21 citations

Preoperative irradiation and 5-fluorouracil suppository for carcinoma of the rectum

1988 • 20 citations

Growth delay in a murine squamous cell tumor after local radiation and concurrent infusional 5-Fluorouracil treatment

1986 • 20 citations

Effects of combined treatments of cis-diamminedichloroplatinum(II), 5-fluorouracil, and X-rays on growth of human cancer nodules maintained in continuous organotypic culture.

1985 • 19 citations

The Relevance of α/β Ratios Determinedin Vitrofor Human Cell Lines to the Understanding ofin VivoValues

1989 • 17 citations

Coordinate Control of S Phase Onset and Thymidine Kinase Expression

1989 • 15 citations

Phase I–II pilot of whole abdominal radiation and concomitant 5-FU as an adjuvant in colon cancer: A southwest oncology group study

1988 • 14 citations

Comparative Antitumor Activity of 5‐Fluorouracil and 5′‐Deoxy‐5‐fluorouridine in Combination with Radiation Therapy in Mice Bearing Colon 26 Adcnocarcinoma

1989 • 13 citations

5-fluorouracil chemotherapy and pelvic radiation in the treatment of large bowel cancer: Decreased toxicity in combined treatment with 5-fluorouracil administration through the intraperitoneal route

1986 • 13 citations

An enzymatic method for distinguishing deoxyuridine and deoxythymidine nucleotide pools and its application for determining ribonucleotide reductase activity

1979 • 10 citations

Treatment of Unresectable Pancreatic Carcinoma Using Irradiation with Concurrent Intravenous 5-FU Infusion Therapy

1988 • 9 citations

Combined 5- Fluorouracil and Radiation Therapy Following Resection of Locally Advanced Gastric Carcinoma: A 5- Years Follow-up

1988 • 5 citations

Influence of radiation therapy on cure and recurrence rates.

1989 • 3 citations