Cancer/testis antigens, gametogenesis and cancer

A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

1991 • 3,493 citations

Meiosis-Specific DNA Double-Strand Breaks Are Catalyzed by Spo11, a Member of a Widely Conserved Protein Family

1997 • 1,751 citations

DNA hypermethylation in tumorigenesis: epigenetics joins genetics

2000 • 1,628 citations

A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening

1997 • 1,235 citations

The DNA sequence of the human X chromosome

2005 • 1,118 citations

Human neoplasms elicit multiple specific immune responses in the autologous host.

1995 • 1,097 citations

Cancer/testis antigens: an expanding family of targets for cancer immunotherapy

2002 • 851 citations

Hypomethylation of DNA from Benign and Malignant Human Colon Neoplasms

1985 • 844 citations

Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by geneMAGE-3 and presented by HLA-A1

1999 • 803 citations

Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes.

1994 • 771 citations

Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse.

1979 • 736 citations

The cancer/testis genes: review, standardization, and commentary.

2004 • 670 citations

BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes

1995 • 598 citations

Structure, chromosomal localization, and expression of 12 genes of the MAGE family

1994 • 595 citations

A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma.

1995 • 591 citations

DNA Methylation Is the Primary Silencing Mechanism for a Set of Germ Line- and Tumor-Specific Genes with a CpG-Rich Promoter

1999 • 589 citations

The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.

1996 • 552 citations

Functional and structural diversity of the human Dickkopf gene family

1999 • 486 citations

An overview of the MAGE gene family with the identification of all human members of the family.

2001 • 477 citations

Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4+ and CD8+ T cell responses in humans

2004 • 446 citations

Chromatin remodelling and epigenetic features of germ cells

2005 • 437 citations

Induction of primary NY-ESO-1 immunity: CD8+ T lymphocyte and antibody responses in peptide-vaccinated patients with NY-ESO-1+ cancers

2000 • 435 citations

Cancer immunology: the search for specificity--G. H. A. Clowes Memorial lecture.

1981 • 395 citations

BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma

2002 • 354 citations

A SPECIFIC COMPLEMENT-FIXING ANTIGEN PRESENT IN SV40 TUMOR AND TRANSFORMED CELLS

1963 • 320 citations

Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library

1998 • 307 citations

Expression of the MAGE-1 tumor antigen is up-regulated by the demethylating agent 5-aza-2'-deoxycytidine.

1994 • 292 citations

Cancer Tumor antigens

1997 • 289 citations

Identification of a meiosis-specific protein as a member of the class of cancer/testis antigens

1998 • 281 citations

Acetylation-Dependent Chromatin Reorganization by BRDT, a Testis-Specific Bromodomain-Containing Protein

2003 • 274 citations

The SSX-2 gene, which is involved in the t(X;18) translocation of synovial sarcomas, codes for the human tumor antigen HOM-MEL-40.

1996 • 254 citations

T-cell-mediated cytotoxicity against autologous malignant melanoma: analysis with interleukin 2-dependent T-cell cultures.

1984 • 237 citations

Genes Coding for Tumor Antigens Recognized by Cytolytic T Lymphocytes

1995 • 233 citations

Cancer immunology: the search for specificity.

1982 • 226 citations

TAP (NXF1) Belongs to a Multigene Family of Putative RNA Export Factors with a Conserved Modular Architecture

2000 • 224 citations

The Human Cysteine‐Rich Secretory Protein (CRISP) Family

1996 • 218 citations

Transfection and expression of a gene coding for a human melanoma antigen recognized by autologous cytolytic T lymphocytes

1992 • 198 citations

Cytolytic T-cell clones against an autologous human melanoma: specificity study and definition of three antigens by immunoselection.

1989 • 188 citations

Identification of a new MAGE gene with tumor-specific expression by representational difference analysis.

1998 • 184 citations

Large Scale Identification of Human Hepatocellular Carcinoma-Associated Antigens by Autoantibodies

2002 • 180 citations

Characterization of the GAGE genes that are expressed in various human cancers and in normal testis.

1999 • 167 citations

Functional Domains of the SYT and SYT-SSX Synovial Sarcoma Translocation Proteins and Co-Localization with the SNF Protein BRM in the Nucleus

1999 • 153 citations

Serological detection of cutaneous T-cell lymphoma-associated antigens

2001 • 148 citations

Physical and Functional Interactions of Neuronal Growth Suppressor Necdin with p53

1999 • 146 citations

Fertilin β and other ADAMs as integrin ligands: insights into cell adhesion and fertilization

2001 • 145 citations

5-aza-2'-deoxycytidine-induced expression of functional cancer testis antigens in human renal cell carcinoma: immunotherapeutic implications.

2002 • 142 citations

Monoclonal antibody MA454 reveals a heterogeneous expression pattern of MAGE-1 antigen in formalin-fixed paraffin embedded lung tumours

2000 • 141 citations

Identification of cancer/testis genes by database mining and mRNA expression analysis

2002 • 140 citations

Expression of cancer-testis antigens in lung cancer: definition of bromodomain testis-specific gene (BRDT) as a new CT gene, CT9

2000 • 137 citations

Molecular Expression Analysis of Restrictive Receptor for Interleukin 13, a Brain Tumor-associated Cancer/Testis Antigen

2000 • 134 citations

Overexpression of MAGE/GAGE genes in paclitaxel/doxorubicin-resistant human cancer cell lines.

2003 • 133 citations

Melanoma Antigen Gene Protein MAGE-11 Regulates Androgen Receptor Function by Modulating the Interdomain Interaction

2005 • 133 citations

Expression of cancer/testis (CT) antigens in lung cancer

2003 • 131 citations

TheSSXgene family: Characterization of 9 complete genes

2002 • 130 citations

Combined use of oligonucleotide and tissue microarrays identifies cancer/testis antigens as biomarkers in lung carcinoma.

2002 • 128 citations

The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation

2003 • 125 citations

Identification on a Human Sarcoma of Two New Genes with Tumor-specific Expression

2000 • 124 citations

CT10: A new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational-difference analysis

2000 • 124 citations

Human chorionic gonadotropin-beta subunit gene expression in cultured human fetal and cancer cells of different types and origins

1995 • 123 citations

Frequent hypomethylation in multiple promoter CpG islands is associated with global hypomethylation, but not with frequent promoter hypermethylation

2004 • 123 citations

MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression.

2000 • 122 citations

Multiple splice variants of lactate dehydrogenase C selectively expressed in human cancer.

2002 • 119 citations

Identification and Characterization of a Novel Cancer/Testis Antigen Gene CAGE

2002 • 117 citations

Mammalian Protein SCP1 Forms Synaptonemal Complex-like Structures in the Absence of Meiotic Chromosomes

2004 • 116 citations

Immunomic analysis of human sarcoma

2003 • 113 citations

Identification of proacrosin binding protein sp32 precursor as a human cancer/testis antigen

2001 • 109 citations

MAGE-A1 interacts with adaptor SKIP and the deacetylase HDAC1 to repress transcription

2004 • 106 citations

Isolation and characterization of a MAGE gene family in the Xp21.3 region.

1995 • 106 citations

MAGE-A4 Interacts with the Liver Oncoprotein Gankyrin and Suppresses Its Tumorigenic Activity

2003 • 105 citations

Necdin-related MAGE Proteins Differentially Interact with the E2F1 Transcription Factor and the p75 Neurotrophin Receptor

2004 • 104 citations

New gene family defined by MORC, a nuclear protein required for mouse spermatogenesis

1999 • 97 citations

MAGE-B5, MAGE-B6, MAGE-C2, andMAGE-C3: four new members of theMAGE family with tumor-specific expression

2000 • 95 citations

Immunodominant CD4 ⁺ responses identified in a patient vaccinated with full-length NY-ESO-1 formulated with ISCOMATRIX adjuvant

2004 • 92 citations

Human PLU-1 Has Transcriptional Repression Properties and Interacts with the Developmental Transcription Factors BF-1 and PAX9

2003 • 90 citations

Novel Insights into the INK4-CDK4/6-Rb Pathway: Counter Action of Gankyrin against INK4 Proteins Regulates the CDK4-Mediated Phosphorylation of Rb

2002 • 90 citations

The TPTE gene family: cellular expression, subcellular localization and alternative splicing

2003 • 90 citations

Overexpression ofp28/gankyrinin human hepatocellular carcinoma and its clinical significance

2002 • 89 citations

A member of the GAGE family of tumor antigens is an anti-apoptotic gene that confers resistance to Fas/CD95/APO-1, Interferon-gamma, taxol and gamma-irradiation.

2002 • 84 citations

Serum HCGβ and CA 72-4 Are Stronger Prognostic Factors than CEA, CA 19-9 and CA 242 in Pancreatic Cancer

2004 • 82 citations

Human testicular protein TPX1/CRISP-2: localization in spermatozoa, fate after capacitation and relevance for gamete interaction

2005 • 82 citations

XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma.

2000 • 81 citations

Identification of a New, Unorthodox Member of the MAGE Gene Family

1999 • 79 citations

Elevated expression of S100P, CAPL and MAGE 3 in doxorubicin-resistant cell lines

1998 • 77 citations

Five new human cancer‐germline genes identified among 12 genes expressed in spermatogonia

2003 • 76 citations

A Processed Pseudogene Codes for a New Antigen Recognized by a Cd8+ T Cell Clone on Melanoma

2000 • 71 citations

Ectopic Expression of Necdin Induces Differentiation of Mouse Neuroblastoma Cells

2002 • 67 citations

A Member of the GAGE Family of Tumor Antigens is an Anti-Apoptotic Gene that Confers Resistance to Fas/CD95/APO-1, Interferon-g, Taxol and g-irradiation

2002 • 56 citations

Identification of the gonad-specific anion transporter SLCO6A1 as a cancer/testis (CT) antigen expressed in human lung cancer.

2004 • 55 citations

The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines

2003 • 55 citations

TSP50, a possible protease in human testes, is activated in breast cancer epithelial cells.

2002 • 53 citations

Identification of two novel CT antigens and their capacity to elicit antibody response in hepatocellular carcinoma patients

2003 • 50 citations

A novel tumour associated leucine zipper protein targeting to sites of gene transcription and splicing

2002 • 49 citations

cDNA and protein characterization of humanMAGE-10

1999 • 48 citations

The Trophoblast Theory of Cancer (<i>John Beard</i>, 1857–1924) Revisited

1975 • 47 citations

Immunolocalization of Sperm Protein 17 in Human Testis and Ejaculated Spermatozoa

2003 • 46 citations

Functional domains of necdin for protein–protein interaction, nuclear matrix targeting, and cell growth suppression

2004 • 46 citations

A new superinvasive in vitro phenotype induced by selection of human breast carcinoma cells with the chemotherapeutic drugs paclitaxel and doxorubicin

2004 • 46 citations

PLU-1, a transcriptional repressor and putative testis-cancer antigen, has a specific expression and localisation pattern during meiosis

2003 • 44 citations

Frequent expression of new cancer/testis gene D40/AF15q14 in lung cancers of smokers

2002 • 41 citations

Expression profiling of MMA‐1a and splice variant MMA‐1b: New cancer/testis antigens identified in human melanoma

2002 • 36 citations

Localization and expression of TSP50 protein in human and rodent testes

2004 • 36 citations

Cancer/testis antigen CSAGE is concurrently expressed with MAGE in chondrosarcoma

2002 • 32 citations

hMAGE-A1 overexpression reduces TNF-alpha cytotoxicity in ME-180 cells.

2002 • 30 citations

Characterization of sperm protein 17 in human somatic and neoplastic tissue

2002 • 29 citations

hMAGE-A1 Overexpression Reduces TNF-α Cytotoxicity in ME-180 Cells

2002 • 19 citations

Presence of synaptonemal complex protein 1 transversal filament-like protein in human primary spermatocytes

1997 • 19 citations

Introduction

2001 • 6 citations