The α_vintegrin antagonists as novel anticancer agents: an update

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Integrins

2002 • 8,127 citations

Integrin Signaling

1999 • 3,705 citations

Requirement of Vascular Integrin α _v β ₃ for Angiogenesis

1994 • 3,016 citations

Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment

1993 • 2,182 citations

Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model

1998 • 2,040 citations

Integrins and other cell adhesion molecules

1990 • 1,990 citations

Signal transduction from the extracellular matrix.

1993 • 1,727 citations

Crystal Structure of the Extracellular Segment of Integrin αVβ3 in Complex with an Arg-Gly-Asp Ligand

2002 • 1,571 citations

Arg-Gly-Asp: A versatile cell recognition signal

1986 • 1,413 citations

Definition of Two Angiogenic Pathways by Distinct α _v Integrins

1995 • 1,333 citations

Crystal Structure of the Extracellular Segment of Integrin αVβ3

2001 • 1,256 citations

Integrins and anoikis

1997 • 1,145 citations

Angiogenesis and Tumor Metastasis

1998 • 1,013 citations

Detection of tumor angiogenesis in vivo by αvβ3-targeted magnetic resonance imaging

1998 • 851 citations

Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin.

1995 • 840 citations

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

1992 • 831 citations

Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progression.

1990 • 771 citations

Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins.

1991 • 713 citations

The role of αv integrins during angiogenesis: insights into potential mechanisms of action and clinical development

1999 • 651 citations

Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins

2002 • 604 citations

Steps toward mapping the human vasculature by phage display

2002 • 591 citations

Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor.

1987 • 571 citations

Integrin activation controls metastasis in human breast cancer

2001 • 566 citations

A reevaluation of integrins as regulators of angiogenesis

2002 • 546 citations

Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen.

1994 • 447 citations

Involvement of integrins alpha v beta 3 and alpha v beta 5 in ocular neovascular diseases.

1996 • 443 citations

Glioblastoma expression of vitronectin and the alpha v beta 3 integrin. Adhesion mechanism for transformed glial cells.

1991 • 420 citations

Role of the alpha v beta 3 integrin in human melanoma cell invasion.

1992 • 414 citations

A Link Between Cyclin A Expression and Adhesion-Dependent Cell Cycle Progression

1993 • 399 citations

Involvement of integrin alpha V gene expression in human melanoma tumorigenicity.

1992 • 380 citations

Radiolabeled alpha(v)beta3 integrin antagonists: a new class of tracers for tumor targeting.

1999 • 354 citations

Targeting the prostate for destruction through a vascular address

2002 • 285 citations

Vascular integrin alpha(v)beta3: a new prognostic indicator in breast cancer.

1998 • 281 citations

Magnetic resonance contrast enhancement of neovasculature with ?v?3-targeted nanoparticles

2000 • 274 citations

Requirement of the integrin beta 3 subunit for carcinoma cell spreading or migration on vitronectin and fibrinogen

1992 • 239 citations

Integrin alpha(v)beta3 promotes M21 melanoma growth in human skin by regulating tumor cell survival.

1999 • 238 citations

Increased filamin binding to β-integrin cytoplasmic domains inhibits cell migration

2001 • 237 citations

Integrins and GTPases in tumour cell growth, motility and invasion

1998 • 219 citations

Extracellular Matrix-derived Peptide Binds to αvβ3 Integrin and Inhibits Angiogenesis

2001 • 205 citations

Role of integrins in angiogenesis

1996 • 191 citations

A Pilot Trial of Vitaxin, A Humanized Anti-Vitronectin Receptor (antiα_vβ₃) Antibody in Patients with Metastatic Cancer

2001 • 191 citations

Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo.

1995 • 186 citations

Inhibition of angiogenesis and tumor growth by SCH221153, a dual alpha(v)beta3 and alpha(v)beta5 integrin receptor antagonist.

2001 • 176 citations

Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin.

1992 • 170 citations

Expression of Integrin ανβ3 in Small Blood Vessels of Glioblastoma Tumors

1996 • 163 citations

Role of alpha v integrins during angiogenesis.

2000 • 140 citations

Integrins and vascular extracellular matrix assembly.

1997 • 135 citations

Molecular role(s) for integrins in human melanoma invasion.

1999 • 119 citations

Mechanisms of tumour invasion and metastasis: emerging targets for therapy

2002 • 118 citations

Antagonists of integrin alpha v beta 3 inhibit retinal neovascularization in a murine model.

1996 • 118 citations

The pharmacology of the integrins

1994 • 117 citations

Discovery of Orally Active Nonpeptide Vitronectin Receptor Antagonists Based on a 2-Benzazepine Gly-Asp Mimetic

1999 • 115 citations

β3 Integrin Expression in Melanoma Predicts Subsequent Metastasis

1996 • 103 citations

Tumour progression and metastatic behaviour in vivo correlates with integrin expression on melanocytic tumours

1993 • 102 citations

Identification and in vivo efficacy of small-molecule antagonists of integrin αvβ3 (the vitronectin receptor)

2000 • 102 citations

Expression of αvβ3 integrin is less frequent in ovarian epithelial tumors of low malignant potential in contrast to ovarian carcinomas

1997 • 101 citations

Novel small molecule alpha v integrin antagonists: comparative anti-cancer efficacy with known angiogenesis inhibitors.

1999 • 100 citations

Imaging of metastatic melanoma utilising a technetium-99m labelled RGD-containing synthetic peptide

1998 • 100 citations

Pilot study of vitaxin?an angiogenesis inhibitor?in patients with advanced leiomyosarcomas

2001 • 97 citations

Isoxazolines as Potent Antagonists of the Integrin α_vβ₃

1999 • 85 citations

Disubstituted Indazoles as Potent Antagonists of the Integrin α_vβ₃

1999 • 71 citations

Solid-phase synthesis of a selective αvβ3 integrin antagonist library

1997 • 69 citations

α_v‐Integrins in human melanoma: Gain of α_vβ₃ and loss OF α_vβ₅ are related to tumor progression in situ but not to metastatic capacity of cell lines in nude mice

1995 • 59 citations

Integrins: Structure, Function, and Biological Properties

1993 • 58 citations

Neovascular Targeting with Cyclic RGD Peptide (cRGDf-ACHA) to Enhance Delivery of Radioimmunotherapy

2000 • 56 citations

In vitro and in vivo effects of a cyclic peptide with affinity for the ανβ3 integrin in human melanoma cells

2000 • 55 citations

A specific sequence of the noncollagenous domain of the alpha3(IV) chain of type IV collagen inhibits expression and activation of matrix metalloproteinases by tumor cells.

2000 • 51 citations

Adhesion molecule profile and malignancy of melanocytic lesions.

1993 • 51 citations

Ligands to the integrin receptor α_vβ₃

2000 • 49 citations

Comparative analysis of integrins in vitro and in vivo in uveal and cutaneous melanomas

1998 • 39 citations

Combinatorial chemistry techniques applied to nonpeptide integrin antagonists.

1998 • 27 citations

Role of V Integrins and Vitronectin in Human Melanoma Cell Growth

1992 • 26 citations

Integrin Chatter and Vascular Function in Diabetic Retinopathy

1997 • 21 citations

Angiogenesis at the Interface between Basic and Clinical Research

1999 • 10 citations

ChemInform Abstract: Discovery of Orally Active Nonpeptide Vitronectin Receptor Antagonists Based on a 2‐Benzazepine Gly‐Asp Mimetic.

2000 • 7 citations