Role of integrins in angiogenesis

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Requirement of Vascular Integrin α _v β ₃ for Angiogenesis

1994 • 3,016 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

Angiogenesis.

1992 • 2,581 citations

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1994 • 2,293 citations

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

1995 • 1,808 citations

Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

1996 • 1,555 citations

Integrins.

1991 • 1,369 citations

Definition of Two Angiogenic Pathways by Distinct α _v Integrins

1995 • 1,333 citations

Collagen family of proteins

1991 • 1,243 citations

Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures.

1988 • 1,209 citations

Integrin function: molecular hierarchies of cytoskeletal and signaling molecules.

1995 • 1,202 citations

Macrophages and angiogenesis

1994 • 1,123 citations

The implications of angiogenesis for the biology and therapy of cancer metastasis

1994 • 1,120 citations

Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix.

1989 • 877 citations

Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin.

1995 • 840 citations

Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro

1989 • 746 citations

Embryonic mesodermal defects in α5 integrin-deficient mice

1993 • 694 citations

Integrin transmembrane signaling and cytoskeletal control

1995 • 616 citations

Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1

1995 • 599 citations

Tumor interactions with the vasculature: angiogenesis and tumor metastasis

1990 • 598 citations

Extracellular proteins that modulate cell-matrix interactions. SPARC, tenascin, and thrombospondin

1991 • 560 citations

Endothelial receptor tyrosine kinases involved in angiogenesis.

1995 • 537 citations

Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information

1992 • 532 citations

Identification of an Inhibitor of Neovascularization from Cartilage

1990 • 481 citations

Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro.

1990 • 466 citations

Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra- and intracellular initiated transmembrane signaling

1993 • 447 citations

Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen.

1994 • 447 citations

Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesis

1988 • 410 citations

Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis.

1996 • 385 citations

Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin.

1995 • 382 citations

An α2β1 Integrin-Dependent Pinocytic Mechanism Involving Intracellular Vacuole Formation and Coalescence Regulates Capillary Lumen and Tube Formation in Three-Dimensional Collagen Matrix

1996 • 352 citations

Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor–type integrins inhibits retinal neovascularization

1996 • 336 citations

Affinity of integrins for damaged extracellular matrix: αvβ3 binds to denatured collagen type I through RGD sites

1992 • 326 citations

An antagonist of integrin αvβ3 prevents maturation of blood vessels during embryonic neovascularization

1995 • 304 citations

Dynamics of matrix turnover during pathologic remodeling of the extracellular matrix.

1996 • 295 citations

Integrins as dynamic regulators of vascular function

1994 • 289 citations

Embryonic lethal mutation in mouse collagen I gene causes rupture of blood vessels and is associated with erythropoietic and mesenchymal cell death

1984 • 285 citations

Endothelial cell proliferation during angiogenesis. In vitro modulation by basement membrane components.

1986 • 277 citations

First steps of tumor-related angiogenesis.

1991 • 241 citations

Inhibition of angiogenesis through modulation of collagen metabolism.

1988 • 240 citations

The Bcl-2 family of proteins: regulators of cell death and survival

1994 • 238 citations

Interstitial Collagenase Is Required for Angiogenesis in Vitro

1994 • 231 citations

A role for sialyl Lewis-X/A glycoconjugates in capillary morphogenesis

1993 • 211 citations

Blood Vessel Fibronectin Increases in Conjunction with Endothelial Cell Proliferation and Capillary Ingrowth During Wound Healing

1982 • 211 citations

Cytokine networks in solid human tumors: regulation of angiogenesis

1994 • 209 citations

Control of Growth and Differentiation of Vascular Cells by Extracellular Matrix Proteins

1991 • 204 citations

Transient functional expression of alphaVbeta 3 on vascular cells during wound repair.

1996 • 203 citations

Differential expression of extracellular proteins is correlated with angiogenesis in vitro.

1991 • 199 citations

In vitro model of angiogenesis using a human endothelium‐derived permanent cell line: Contributions of induced gene expression, G‐proteins, and integrins

1992 • 198 citations

Regulation of in vitro capillary tube formation by anti-integrin antibodies.

1993 • 194 citations

Basic FGF and TGF-β differentially modulate integrin expression of human microvascular endothelial cells

1992 • 163 citations

Tumor cell adhesion to the extracellular matrix and signal transduction mechanisms implicated in tumor cell motility, invasion and metastasis

1992 • 150 citations

Basic Fibroblast Growth Factor Increases Expression of the αvβ3 Integrin Complex on Human Microvascular Endothelial Cells

1994 • 140 citations

Antibodies to β₁‐integrins cause alterations of aortic vasculogenesis, in vivo

1992 • 126 citations

The microvascular extracellular matrix. Developmental changes during angiogenesis in the aortic ring-plasma clot model.

1987 • 118 citations

An antagonist of integrin αvβ3 prevents maturation of blood vessels during embryonic neovascularization

1995 • 104 citations

Differential modulation of vascular cell integrin and extracellular matrix expression in vitro by TGF‐β1 correlates with reciprocal effects on cell migration⁺

1992 • 93 citations

Distinct biological consequences of integrin alpha v beta 3-mediated melanoma cell adhesion to fibrinogen and its plasmic fragments.

1992 • 83 citations

Inhibitors of basement membrane collagen synthesis prevent endothelial cell alignment in matrigel in vitro and angiogenesis in vivo.

1994 • 81 citations

Inhibition of angiogenesis in vitro by Arg-Gly-Asp-containing synthetic peptide.

1991 • 77 citations

Cellular adhesion molecules. Newly identified mediators of angiogenesis.

1996 • 76 citations

Confocal Microscopic Analysis of Integrin Expression on the Microvasculature and its Sprouts in the Neonatal Foreskin

1994 • 75 citations

Expression and Modulation of the Vitronectin Receptor on Human Dermal Microvascular Endothelial Cells

1992 • 70 citations

Role of laminin in endothelial cell recognition and differentiation

1993 • 61 citations

Identification of a role of the vitronectin receptor and protein kinase C in the induction of endothelial cell vascular formation

1993 • 56 citations

Differential expression of type I collagen and cellular fibronectin isoforms in endothelial cell variants

1993 • 17 citations

Lepromatous placentitis and intrauterine fetal infection in lepromatous nine-banded armadillos (Dasypus novemcinctus).

1987 • 12 citations