Targeting inhibitor of apoptosis proteins in combination with dacarbazine or TRAIL in melanoma cells

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

2002 • 18,672 citations

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

2010 • 14,016 citations

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

2010 • 3,500 citations

X-linked IAP is a direct inhibitor of cell-death proteases

1997 • 1,961 citations

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

2010 • 1,767 citations

Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

2006 • 770 citations

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

2002 • 739 citations

IAPs, RINGs and ubiquitylation

2005 • 591 citations

Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis

2004 • 357 citations

Palliative therapy of disseminated malignant melanoma: a systematic review of 41 randomised clinical trials

2003 • 323 citations

IAP Regulation of Metastasis

2010 • 281 citations

Diagnosis and treatment of cutaneous melanoma: state of the art 2006*

2007 • 222 citations

Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma

2007 • 189 citations

Inhibitor of Apoptosis Protein cIAP2 Is Essential for Lipopolysaccharide-Induced Macrophage Survival

2005 • 188 citations

Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs

2006 • 172 citations

Small Molecule XIAP Inhibitors Enhance TRAIL-Induced Apoptosis and Antitumor Activity in Preclinical Models of Pancreatic Carcinoma

2009 • 152 citations

Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP

2004 • 137 citations

[2] Techniques for human adenovirus vector construction and characterization

1995 • 118 citations

cIAP1 Localizes to the Nuclear Compartment and Modulates the Cell Cycle

2005 • 116 citations

Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells

2006 • 108 citations

A new experimental metastasis model in athymic nude mice, the human malignant melanoma lox

1988 • 101 citations

The X-linked inhibitor of apoptosis protein (XIAP) is up-regulated in metastatic melanoma, and XIAP cleavage by Phenoxodiol is associated with Carboplatin sensitization

2007 • 100 citations

Aberrant regulation and function of wild-type p53 in radioresistant melanoma cells.

2000 • 98 citations

TRAIL and Other TRAIL Receptor Agonists as Novel Cancer Therapeutics

2009 • 89 citations

Resistance of melanoma cells to TRAIL does not result from upregulation of antiapoptotic proteins by NF-κB but is related to downregulation of initiator caspases and DR4

2006 • 85 citations

Extrapulmonary, tissue-specific metastasis formation in nude mice injected with FEMX-I human melanoma cells.

1988 • 80 citations

Survivin expression by metastatic melanoma predicts poor disease outcome in patients receiving adjuvant polyvalent vaccine

2005 • 79 citations

Effects of cIAP-1, cIAP-2 and XIAP triple knockdown on prostate cancer cell susceptibility to apoptosis, cell survival and proliferation

2009 • 68 citations

Mapatumumab and lexatumumab induce apoptosis in TRAIL-R1 and TRAIL-R2 antibody-resistant NSCLC cell lines when treated in combination with bortezomib

2009 • 65 citations

Expression and Function of Bcl-2 Proteins in Melanoma

2008 • 62 citations

Real Time Analysis of Tumor Necrosis Factor-related Apoptosis-inducing Ligand/Cycloheximide-induced Caspase Activities during Apoptosis Initiation

2008 • 62 citations

Expression of inhibitor-of-apoptosis protein family members in malignant mesothelioma

2007 • 59 citations

XIAP is highly expressed in esophageal cancer and its downregulation by RNAi sensitizes esophageal carcinoma cell lines to chemotherapeutics

2007 • 57 citations

X Chromosome-linked Inhibitor of Apoptosis Regulates Cell Death Induction by Proapoptotic Receptor Agonists

2009 • 57 citations

Mechanism of action and pharmacology studies with DTIC (NSC-45388).

1976 • 56 citations

Melanoma inhibitor of apoptosis protein is expressed differentially in melanoma and melanocytic naevus, but similarly in primary and metastatic melanomas

2005 • 44 citations

Induction of apoptosis and/or necrosis following exposure to antitumour agents in a melanoma cell line, probably through modulation of Bcl-2 family proteins

2003 • 44 citations

Bim Expression Is Reduced in Human Cutaneous Melanomas

2007 • 43 citations

Interaction of heat-shock protein 90β isoform (HSP90β) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation

2008 • 42 citations

Caspases and inhibitor of apoptosis proteins in cutaneous and mucosal melanoma: expression profile and clinicopathologic significance

2009 • 40 citations

Inhibition of Telomerase Increases Resistance of Melanoma Cells to Temozolomide, but Not to Temozolomide Combined with Poly (ADP-Ribose) Polymerase Inhibitor

2003 • 39 citations

Sensitization of melanoma cells to TRAIL by UVB-induced and NF-κB-mediated downregulation of xIAP

2008 • 32 citations

Immunohistochemical detection of XIAP in melanoma

2007 • 32 citations

B16 and cloudman S91 mouse melanoma cells susceptibility to apoptosis after dacarbazine treatment.

2006 • 8 citations