Palliative therapy of disseminated malignant melanoma: a systematic review of 41 randomised clinical trials

The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials

2001 • 5,358 citations

Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells

1998 • 2,916 citations

Prognostic Factors Analysis of 17,600 Melanoma Patients: Validation of the American Joint Committee on Cancer Melanoma Staging System

2001 • 2,365 citations

Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684.

1996 • 2,073 citations

The CONSORT Statement: Revised Recommendations for Improving the Quality of Reports of Parallel-Group Randomized Trials

2001 • 1,432 citations

Vaccination with Mage-3a1 Peptide–Pulsed Mature, Monocyte-Derived Dendritic Cells Expands Specific Cytotoxic T Cells and Induces Regression of Some Metastases in Advanced Stage IV Melanoma

1999 • 1,260 citations

Randomized Phase III Study of Temozolomide Versus Dacarbazine in the Treatment of Patients With Advanced Metastatic Malignant Melanoma

2000 • 1,252 citations

Phase III Multicenter Randomized Trial of the Dartmouth Regimen Versus Dacarbazine in Patients With Metastatic Melanoma

1999 • 756 citations

The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis

2001 • 610 citations

Prognostic factors in 1,521 melanoma patients with distant metastases.

1995 • 567 citations

bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice

1998 • 496 citations

Rapid Induction of Tumor-specific Type 1 T Helper Cells in Metastatic Melanoma Patients by Vaccination with Mature, Cryopreserved, Peptide-loaded Monocyte-derived Dendritic Cells

2002 • 484 citations

Randomised trial of interferon α-2a as adjuvant therapy in resected primary melanoma thicker than 1·5 mm without clinically detectable node metastases

1998 • 437 citations

Cancer Immunotherapy With Peptide-Based Vaccines: What Have We Achieved? Where Are We Going?

2002 • 400 citations

Sequential Biochemotherapy Versus Chemotherapy for Metastatic Melanoma: Results From a Phase III Randomized Trial

2002 • 378 citations

Prospective Randomized Trial of the Treatment of Patients With Metastatic Melanoma Using Chemotherapy With Cisplatin, Dacarbazine, and Tamoxifen Alone or in Combination With Interleukin-2 and Interferon Alfa-2b

1999 • 318 citations

Phase III trial of dacarbazine versus dacarbazine with interferon alpha-2b versus dacarbazine with tamoxifen versus dacarbazine with interferon alpha-2b and tamoxifen in patients with metastatic malignant melanoma: an Eastern Cooperative Oncology Group study.

1998 • 309 citations

Increasing Incidence of Cutaneous Melanoma in Queensland, Australia

1992 • 271 citations

Treatment of Metastatic Malignant Melanoma with Dacarbazine plus Tamoxifen

1992 • 241 citations

Primary cutaneous melanoma. Identification of prognostic groups and estimation of individual prognosis for 5093 patients

1995 • 229 citations

Incidence of and survival from malignant melanoma in Scotland: an epidemiological study

2002 • 221 citations

Improved results with the addition of interferon alfa-2b to dacarbazine in the treatment of patients with metastatic malignant melanoma.

1991 • 200 citations

Interferon alfa-2a and interleukin-2 with or without cisplatin in metastatic melanoma: a randomized trial of the European Organization for Research and Treatment of Cancer Melanoma Cooperative Group.

1997 • 197 citations

Randomized phase III trial of treatment with high-dose interleukin-2 either alone or in combination with interferon alfa-2a in patients with advanced melanoma.

1993 • 181 citations

Phase II trial of intralesional therapy with interleukin-2 in soft-tissue melanoma metastases

2003 • 180 citations

A prospective evaluation of a triple-drug regimen containing cisplatin, vinblastine, and dacarbazine (CVD) for metastatic melanoma

1989 • 179 citations

Treatment of metastatic melanoma with combined chemotherapy containing cisplatin, vinblastine and dacarbazine (CVD) and biotherapy using interleukin-2 and interferon-α

1996 • 176 citations

Randomized, double-blind, placebo-controlled trial comparing the response rates of carmustine, dacarbazine, and cisplatin with and without tamoxifen in patients with metastatic melanoma. National Cancer Institute of Canada Clinical Trials Group.

1996 • 176 citations

Results From a Randomized Phase III Study Comparing Combined Treatment With Histamine Dihydrochloride Plus Interleukin-2 Versus Interleukin-2 Alone in Patients With Metastatic Melanoma

2002 • 166 citations

Single-agent DTIC versus combination chemotherapy with or without immunotherapy in metastatic melanoma: a meta-analysis of 3273 patients from 20 randomized trials

2001 • 153 citations

Multicenter randomized trial of dacarbazine alone or in combination with two different doses and schedules of interferon alfa-2a in the treatment of advanced melanoma.

1994 • 153 citations

Cisplatin, Dacarbazine With or Without Subcutaneous Interleukin-2, and Interferon Alfa-2b in Advanced Melanoma Outpatients: Results From an Italian Multicenter Phase III Randomized Clinical Trial

2002 • 124 citations

Interferon-alpha 2a does not improve response or survival when combined with dacarbazine in metastatic malignant melanoma: results of a multi-institutional Australian randomized trial.

1993 • 121 citations

Randomized phase III trial of vinblastine, bleomycin, and cis-dichlorodiammine-platinum versus dacarbazine in malignant melanoma.

1984 • 110 citations

Metastatic melanoma

2001 • 104 citations

Combination of Chemotherapy With Interleukin-2 and Interferon Alfa for the Treatment of Metastatic Melanoma

1999 • 102 citations

A randomized phase III study comparing dacarbazine, BCNU, cisplatin and tamoxifen with dacarbazine and interferon in advanced melanoma

2000 • 101 citations

RGD Peptides and Monoclonal Antibodies, Antagonists of αv-Integrin, Enter the Cells by Independent Endocytic Pathways

2001 • 94 citations

Combination chemotherapy with or without s.c. IL-2 and IFN-α: results of a prospectively randomized trial of the Cooperative Advanced Malignant Melanoma Chemoimmunotherapy Group (ACIMM)

2002 • 93 citations

Desmoids in familial adenomatous polyposis are monoclonal proliferations

2000 • 93 citations

Dacarbazine and interferon α with or without interleukin 2 in metastatic melanoma: a randomized phase III multicentre trial of the Dermatologic Cooperative Oncology Group (DeCOG)

2001 • 89 citations

Randomized phase II trial of BCDT [carmustine (BCNU), cisplatin, dacarbazine (DTIC) and tamoxifen] with or without interferon alpha (IFN-α) and interleukin (IL-2) in patients with metastatic melanoma

1998 • 88 citations

Phase II randomized study of dacarbazine, carmustine, cisplatin and tamoxifen versus dacarbazine alone in advanced melanoma patients

2001 • 84 citations

Phase III Clinical Trial of the Combination of Cisplatin, Dacarbazine, and Carmustine With or Without Tamoxifen in Patients With Advanced Malignant Melanoma

1999 • 74 citations

Malignant Melanoma: Prognostic Indicators

1997 • 71 citations

Chemoimmunotherapy of advanced malignant melanoma: sequential administration of subcutaneous interleukin-2 and interferon-α after intravenous dacarbazine and carboplatin or intravenous dacarbazine, cisplatin, carmustine and tamoxifen

1995 • 71 citations

Randomized trial of treatment with cisplatin and interleukin-2 either alone or in combination with interferon-?-2a in patients with metastatic melanoma

1999 • 71 citations

A phase III randomized trial of dacarbazine and carboplatin with and without tamoxifen in the treatment of patients with metastatic melanoma

1999 • 68 citations

Prospective Randomized Comparison of Dacarbazine (DTIC) Versus DTIC Plus Interferon-Alpha (IFN-α) in Metastatic Melanoma

2001 • 63 citations

Dacarbazine–vindesine versus dacarbazine–vindesine–cisplatin in disseminated malignant melanoma. A randomised phase III trial

1998 • 61 citations

Outpatient Biochemotherapy With Interleukin-2 and Interferon Alfa-2b in Patients With Metastatic Malignant Melanoma: Results of Two Phase II Cytokine Working Group Trials

2001 • 58 citations

Comparison of the combination of 1, 3-bis(2-chloroethyl)-l-nitrosourea (BCNU) and vincristine with two dose schedules of 5-(3,3-dimethyl-l-triazino) imidazole 4-carboxamide (DTIC) in the treatment of disseminated malignant melanoma

1975 • 48 citations

DTIC (nsc-45388) and combination therapy for melanoma. I. Studies with DTIC, BCNU (NSC-409962), CCNU (NSC-79037), vincristine (NSC-67574), and hydroxyurea (NSC-32065).

1976 • 47 citations

Dacarbazine versus dacarbazine-vindesine in disseminated malignant melanoma: A randomized phase II study

1989 • 43 citations

Combination chemotherapy plus BCG in the treatment of disseminated malignant melanoma: A southwest oncology group study

1982 • 41 citations

Combination chemotherapy in metastatic malignant melanoma.A randomized study of three DTIC-containing combinations

1978 • 39 citations

Targeting integrins alpha v beta 3 and alpha v beta 5 for blocking tumor-induced angiogenesis.

2000 • 37 citations

Bis chloroethyl nitrosourea, vincristine, dimethyl triazeno imidazole carboxamide and chlorpromazine combination chemotherapy in disseminated malignant melanoma

1977 • 36 citations

Targeting Integrins αvβ3 and αvβ5 for Bloking Tumor-Induced Angiogenesis

2000 • 34 citations

Experience with interferon alpha 2b combined with dacarbazine in the treatment of metastatic malignant melanoma

1995 • 26 citations

Combination chemotherapy plus levamisole in the treatment of disseminated malignant melanoma a southwest oncology group study

1984 • 24 citations

Is There a Standard for the Palliative Treatment of Melanoma?

2002 • 21 citations

Controlled Study with Imidazole Carboxamide (DTIC), DTIC + Bacillus Calmette-Guérin (BCG), and DTIC + Corynebacterium Parvum in Advanced Malignant Melanoma

1984 • 20 citations

Combination chemotherapy plus levamisole in the treatment of disseminated malignant melanoma a southwest oncology group study

1984 • 18 citations

Multi-institutional phase II randomized trial of integrated therapy with cisplatin, dacarbazine, vindesine, subcutaneous interleukin-2, interferon α2a and tamoxifen in metastatic melanoma

1999 • 17 citations

Comparison of the efficacy of two different dosage dacarbazine-based regimens and two regimens without dacarbazine in metastatic melanoma: a single-centre randomized four-arm study

2002 • 17 citations

A trial of imidazole carboxamide and corynebacteriumparvum in disseminated melanoma. Clinical and immunologic results

1980 • 16 citations

[Chemotherapy in advanced malignant melanoma. Results of a controlled trial comparing a combination of dacarbazine (DTIC) and detorubicin with dacarbazine alone].

1982 • 13 citations

A randomised phase II study of carmustine alone or in combination with tomour necrosis factor in patients with advanced melanoma

1992 • 11 citations

Treatment of metastatic malignant melanoma with dacarbazine plus tamoxifen, or vindesine plus tamoxifen

2003 • 10 citations

Deleted Work

1955 • 0 citations