Inhibition of Telomerase Increases Resistance of Melanoma Cells to Temozolomide, but Not to Temozolomide Combined with Poly (ADP-Ribose) Polymerase Inhibitor

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

1989 • 1,509 citations

Randomized Phase III Study of Temozolomide Versus Dacarbazine in the Treatment of Patients With Advanced Metastatic Malignant Melanoma

2000 • 1,252 citations

Inhibition of telomerase limits the growth of human cancer cells

1999 • 1,032 citations

Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials

1997 • 777 citations

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

1999 • 695 citations

Repair of O6-alkylguanine by alkyltransferases

2000 • 569 citations

Detection of telomerase activity in human cells and tumors by a telomeric repeat amplification protocol (TRAP)

1995 • 395 citations

Natural and pharmacological regulation of telomerase

2002 • 347 citations

p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells.

2001 • 343 citations

Cancer Research Campaign phase II trial of temozolomide in metastatic melanoma.

1995 • 290 citations

Involvement of the Mismatch Repair System in Temozolomide-Induced Apoptosis

1998 • 275 citations

O6-benzylguanine and its role in chemotherapy.

1997 • 214 citations

Pharmacologic disruption of base excision repair sensitizes mismatch repair-deficient and -proficient colon cancer cells to methylating agents.

1999 • 160 citations

Inhibition of telomerase increases the susceptibility of human malignant glioblastoma cells to cisplatin-induced apoptosis

1998 • 155 citations

A Chemical and Genetic Approach Together Define the Biological Consequences of 3-Methyladenine Lesions in the Mammalian Genome

1998 • 126 citations

3-aminobenzamide and/or O6-benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment in cell lines of variable mismatch repair status and O6-alkylguanine-DNA alkyltransferase activity

1996 • 121 citations

Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase.

2001 • 117 citations

Telomere dysfunction alters the chemotherapeutic profile of transformed cells

2001 • 112 citations

Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site

2002 • 82 citations

C-Myc Down-Regulation Increases Susceptibility to Cisplatin through Reactive Oxygen Species-Mediated Apoptosis in M14 Human Melanoma Cells

2001 • 79 citations

Telomerase activity in melanoma and non-melanoma skin cancer

1998 • 66 citations

Expression of DNA repair proteins hMSH2, hMSH6, hMLH1,O6-methylguanine-DNA methyltransferase and N-methylpurine-DNA glycosylase in melanoma cells with acquired drug resistance

1999 • 65 citations

Groove- and sequence-selective alkylation of DNA by sulfonate esters tethered to lexitropsins

1993 • 60 citations

Treatment with temozolomide and poly(ADP-ribose) polymerase inhibitors induces early apoptosis and increases base excision repair gene transcripts in leukemic cells resistant to triazene compounds

1999 • 58 citations

Temozolomide for treating brain metastases

2001 • 57 citations

Inhibition of O⁶-Alkylguanine DNA-Alkyltransferase or Poly(ADP-ribose) Polymerase Increases Susceptibility of Leukemic Cells to Apoptosis Induced by Temozolomide

1997 • 57 citations

The in Vitro Methylation of DNA by a Minor Groove Binding Methyl Sulfonate Ester

1996 • 38 citations

Poly (ADP-ribose) polymerase inhibitor increases apoptosis and reduces necrosis induced by a DNA minor groove binding methyl sulfonate ester

2001 • 38 citations

Combined effects of adenovirus-mediated wild-type p53 transduction, temozolomide and poly (ADP-ribose) polymerase inhibitor in mismatch repair deficient and non-proliferating tumor cells

2001 • 32 citations

Combination therapy of 2-5A antisense against telomerase RNA and cisplatin for malignant gliomas

2001 • 29 citations

Reconstitution of hTERT restores tumorigenicity in melanoma-derived c-Myc low-expressing clones

2002 • 27 citations

Attenuation of telomerase activity does not increase sensitivity of human melanoma cells to anticancer agents

2000 • 25 citations

Analysis of the DNA mismatch repair proteins expression in malignant melanomas.

2001 • 24 citations

CD40 expressed on human melanoma cells mediates T cell co-stimulation and tumor cell growth

2000 • 22 citations

Immunocytochemical detection of hMSH2 and hMLH1 expression in oral melanoma.

2000 • 16 citations

Cytotoxic and clastogenic effects of a DNA minor groove binding methyl sulfonate ester in mismatch repair deficient leukemic cells

2000 • 15 citations

Apoptotic and genotoxic effects of a methyl sulfonate ester that selectively generates N3-methyladenine and poly(ADP-ribose) polymerase inhibitors in normal peripheral blood lymphocytes

2002 • 12 citations

Clinical applications of telomerase in cancer treatment

2000 • 6 citations

True

1999 • 4 citations