Requirement of dendritic cells and B cells in the clonal deletion of Mls-reactive T cells in the thymus.

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

1989 • 778 citations

Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells

1985 • 613 citations

Identification of a novel cell type in peripheral lymphoid organs of mice. V. Purification of spleen dendritic cells, new surface markers, and maintenance in vitro.

1979 • 514 citations

The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens

1988 • 491 citations

Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells

1989 • 462 citations

The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype.

1984 • 389 citations

Dendritic cells are the principal stimulators of the primary mixed leukocyte reaction in mice

1983 • 367 citations

Resting and sensitized T lymphocytes exhibit distinct stimulatory (antigen-presenting cell) requirements for growth and lymphokine release.

1984 • 346 citations

T Cell Development in the Adult Murine Thymus: Changes in the Expression of the Surface Antigens Ly2, L3T4 and B2A2 during Development from Early Precursor Cells to Emigrants

1984 • 344 citations

The effect of thymus environment on T cell development and tolerance

1988 • 330 citations

Effect of deoxyguanosine on lymphopoiesis in the developing thymus rudiment in vitro: Application in the production of chimeric thymus rudiments

1982 • 324 citations

A Nondeletional Mechanism of Thymic Self Tolerance

1989 • 322 citations

The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus

1989 • 318 citations

Does T-cell tolerance require a dedicated antigen-presenting cell?

1989 • 288 citations

Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage

1988 • 265 citations

T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I–E

1989 • 238 citations

The major histocompatibility complex-restricted antigen receptor on T cells: Distribution on thymus and peripheral T cells

1984 • 210 citations

A single stem cell can recolonize an embryonic thymus, producing phenotypically distinct T-cell populations

1985 • 199 citations

Intrathymic deletion of self-reactive cells prevented by neonatal anti-CD4 antibody treatment

1988 • 197 citations

Bone marrow origin of Ia-positive cells in the medulla rat thymus.

1981 • 197 citations

Deletion of self-reactive T cells before entry into the thymus medulla

1988 • 171 citations

A role for clonal inactivation in T cell tolerance to Mis-1a

1990 • 166 citations

Thymocytes appear to ignore class I major histocompatibility complex antigens expressed on thymus epithelial cells

1984 • 158 citations

Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities.

1990 • 146 citations

Successful transplantation across major histocompatibility barrier of deoxyguanosine-treated embryonic thymus expressing class II antigens

1984 • 138 citations

Minor but not major histocompatibility antigens of thymus epithelium tolerize precursors of cytolytic T cells

1986 • 109 citations

Postnatal disappearance of self-reactive (V beta 6+) cells from the thymus of Mlsa mice. Implications for T cell development and autoimmunity.

1989 • 108 citations

Two monoclonal rat antibodies with specificity for the beta-chain variable region V beta 6 of the murine T-cell receptor.

1988 • 100 citations

Distinct features of dendritic cells and anti-Ig activated B cells as stimulators of the primary mixed leukocyte reaction.

1989 • 96 citations

Thymic Requirement for Clonal Deletion During T Cell Development

1989 • 95 citations

Restricted tissue distribution of Mlsa determinants. Stimulation of Mlsa-reactive T cells by B cells but not by dendritic cells or macrophages.

1989 • 90 citations

Clonal deletion of self-reactive T cells in irradiation bone marrow chimeras and neonatally tolerant mice. Evidence for intercellular transfer of Mlsa.

1989 • 76 citations

Failure of T Cell Receptor V _β Negative Selection in an Athymic Environment

1989 • 76 citations

Positive and negative selection of T cell receptor V beta domains controlled by distinct cell populations in the thymus.

1989 • 67 citations

Distinct fates of self-specific T cells developing in irradiation bone marrow chimeras: clonal deletion, clonal anergy, or in vitro responsiveness to self-Mls-1a controlled by hemopoietic cells in the thymus.

1990 • 54 citations

Early events in T lymphocyte genesis in the fetal thymus

1984 • 53 citations

Studies on non-H-2-linked lymphocyte-activating determinants. II. Nonexpression of Mls determinants in a mouse strain with an X-linked B lymphocyte immune defect.

1976 • 51 citations

Phenotype of stromal cell‐associated thymocytes in situ is compatible with selection of the T cell repertoire at an “immature” stage of thymic T cell differentiation

1987 • 48 citations

Macrophage factors which enhance the mixed leukocyte reaction initiated by dendritic cells.

1989 • 47 citations

Reconfirmation of indirect induction of radiogenic lymphomas using thymectomized, irradiated B10 mice grafted with neonatal thymuses from Thy 1 congenic donors.

1983 • 44 citations

Characterization of stromal cell populations in the developing thymus of normal and nude mice

1984 • 35 citations

Quantification of the progenitors for thymic T cells in various organs

1988 • 30 citations

Synergistic effect of colony-stimulating factors and IL-2 on prothymocyte proliferation linked to the maturation of macrophage/dendritic cells within L3T4-Lyt-2-Ia-Mac- cells.

1988 • 27 citations

Role of macrophages as modulators but not as stimulators in primary mixed leukocyte reaction

1984 • 27 citations

Difference in the target cells for tolerance induction in relation to the dose of tolerogen.

1972 • 23 citations

Analysis of the development of T cells by transferring precursors into cultured fetal thymus with a microinjector.

1989 • 18 citations

Tolerance induction in TxXBT and TxXB mice.

1975 • 10 citations

Tolerance to Mlsa by clonal deletion of V beta 6+ T cells in bone marrow and thymus chimeras.

1989 • 5 citations