Effect of Tamoxifen on the Enzymatic Activity of Human Cytochrome CYP2B6

Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

1998 • 5,487 citations

Cytochrome P-450: Structure, Mechanism, and Biochemistry

1986 • 2,703 citations

The molecular biology of cytochrome P450s.

1988 • 1,294 citations

Endometrial Cancer in Tamoxifen-Treated Breast Cancer Patients: Findings From the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14 *

1994 • 1,259 citations

The pharmacology and clinical uses of tamoxifen

1984 • 873 citations

Mammalian Microsomal Cytochrome P450 Monooxygenase

2000 • 689 citations

Cytochrome P-450. Multiplicity of isoforms, substrates, and catalytic and regulatory mechanisms

1991 • 675 citations

Cytochrome P450

1995 • 582 citations

Risk of endometrial cancer after tamoxifen treatment of breast cancer

1994 • 574 citations

Rapid separation of low molecular weight solutes from liposomes without dilution

1978 • 444 citations

Expression of Modified Human Cytochrome P450 3A4 in Escherichia coli and Purification and Reconstitution of the Enzyme

1993 • 341 citations

Induction of covalent DNA adducts in rodents by tamoxifen.

1992 • 255 citations

The triphenylethylene drug tamoxifen is a strong liver carcinogen in the rat

1993 • 235 citations

Variable contribution of cytochromes p450 2d6, 2c9 and 3a4 to the 4-hydroxylation of tamoxifen by human liver microsomes

1997 • 221 citations

CYP2D6 catalyzes tamoxifen 4-hydroxylation in human liver.

1997 • 185 citations

Identification of the cytochrome P450 IIIA family as the enzymes involved in the N-demethylation of tamoxifen in human liver microsomes

1991 • 185 citations

The Metabolism of Tamoxifen (I.C.I. 46,474) Part I : In Laboratory Animals

1973 • 181 citations

Role of the Alanine at Position 363 of Cytochrome P450 2B2 in Influencing the NADPH- and Hydroperoxide-Supported Activities

1998 • 170 citations

THE ROLE OF CYP2B6 IN HUMAN XENOBIOTIC METABOLISM*

1999 • 169 citations

Mechanism-Based Inactivators as Probes of Cytochrome P450 Structure and Function

2001 • 128 citations

Cytochrome P-450-mediated activation and irreversible binding of the antiestrogen tamoxifen to proteins in rat and human liver: possible involvement of flavin-containing monooxygenases in tamoxifen activation.

1991 • 121 citations

Expression of Human Cytochrome P450 2B6 in Escherichia coli: Characterization of Catalytic Activity and Expression Levels in Human Liver

2000 • 111 citations

Expression of Cytochrome P450 2D6 in Escherichia coli, Purification, and Spectral and Catalytic Characterization

1995 • 104 citations

Identification of tamoxifen–DNA adducts in the endometrium of women treated with tamoxifen

2000 • 100 citations

4-Hydroxylated Metabolites of the Antiestrogens Tamoxifen and Toremifene Are Metabolized to Unusually Stable Quinone Methides

1999 • 97 citations

Identification of tamoxifen–DNA adducts in the endometrium of women treated with tamoxifen

2000 • 92 citations

Recombinant Human Cytochrome P450 1B1 Expression inEscherichia coli

1998 • 89 citations

Characterization of Cytochrome P450 Enzymes in Human Breast Tissue from Reduction Mammaplasties¹

1998 • 82 citations

Synthesis and Reactivity of a Potential Carcinogenic Metabolite of Tamoxifen: 3,4-Dihydroxytamoxifen-o-quinone

1999 • 77 citations

DNA adduct formation by tamoxifen with rat and human liver microsomal activation systems

1994 • 72 citations

Studies on the metabolism and pharmacokinetics of tamoxifen in normal volunteers.

1980 • 71 citations

Identification of tamoxifen metabolites in human Hep G2 cell line, human liver homogenate, and patients on long-term therapy for breast cancer.

1995 • 69 citations

Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins.

1999 • 68 citations

Species differences in the covalent binding of [14C]tamoxifen to liver microsomes and the forms of cytochrome P450 involved

1995 • 64 citations

Does tamoxifen cause cancer in humans?

1998 • 60 citations

Evidence that the catechol 3,4-Dihydroxytamoxifen is a proximate intermediate to the reactive species binding covalently to proteins.

1996 • 58 citations

Activation of 4-hydroxytamoxifen and the tamoxifen derivative metabolite E by uterine peroxidase to form DNA adducts: Comparison with DNA adducts formed in the uterus of Sprague-Dawley rats treated with tamoxifen

1996 • 55 citations

In Laboratory Animals

1951 • 49 citations

Characterization of Cytochrome P450 Enzymes in Human Breast Tissue from Reduction Mammaplasties

1998 • 49 citations

Microsomal and peroxidase activation of 4-hydroxy-tamoxifen to form DNA adducts: comparison with DNA adducts formed in Sprague-Dawley rats treated with tamoxifen

1995 • 49 citations

Effects of tamoxifen administration on the expression of xenobiotic metabolizing enzymes in rat liver.

1995 • 45 citations

The metabolism of tamoxifen by human cytochromes P450 is rationalized by molecular modelling of the enzyme-substrate interactions: potential importance to its proposed anti-carcinogenic/carcinogenic actions

1996 • 42 citations

Metabolism of tamoxifen by isolated rat hepatocytes: anti-estrogenic activity of tamoxifen N-oxide

1982 • 29 citations

Analysis of the catalytic specificity of cytochrome P450 enzymes through site‐directed mutagenesis

1992 • 26 citations

Multiple Oxidants in Cytochrome P450 Catalyzed Reactions Implications for Drug Metabolism

2001 • 19 citations