Identification of tamoxifen–DNA adducts in the endometrium of women treated with tamoxifen

Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

1998 • 5,487 citations

Tamoxifen for early breast cancer: an overview of the randomised trials

1998 • 4,082 citations

Tamoxifen in the Treatment of Breast Cancer

1998 • 1,295 citations

Endometrial Cancer in Tamoxifen-Treated Breast Cancer Patients: Findings From the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14 *

1994 • 1,259 citations

Tamoxifen Therapy for Breast Cancer and Endometrial Cancer Risk

1999 • 348 citations

The triphenylethylene drug tamoxifen is a strong liver carcinogen in the rat

1993 • 235 citations

Correlation of DNA adduct levels with tumor incidence: carcinogenic potency of DNA adducts

1999 • 133 citations

A comparative study of tamoxifen metabolism in female rat, mouse and human liver microsomes

1994 • 110 citations

A mechanistic hypothesis for DNA adduct formation by tamoxifen following hepatic oxidative metabolism

1994 • 104 citations

³²P-Postlabelled DNA adducts in liver obtained from women treated with tamoxifen

1995 • 100 citations

The tamoxifen dilemma

1999 • 96 citations

Detection of DNA adducts in HL-60 cells treated with hydroquinone and p-benzoquinone by ³²P-postlabeling

1991 • 93 citations

Sulfation of alpha-hydroxytamoxifen catalyzed by human hydroxysteroid sulfotransferase results in tamoxifen-DNA adducts

1998 • 80 citations

Tamoxifen−DNA Adducts Detected in the Endometrium of Women Treated with Tamoxifen

1999 • 80 citations

Identification of Tamoxifen−DNA Adducts Formed by α-Sulfate Tamoxifen and α-Acetoxytamoxifen

1997 • 79 citations

Reduced genotoxicity of [D₅-ethyl]-tamoxifen implicates α-hydroxylation of the ethyl group as a major pathway of tamoxifen activation to a liver carcinogen

1994 • 77 citations

Identification of tamoxifen-DNA adducts formed by 4-hydroxytamoxifen quinone methide

1997 • 66 citations

The metabolic activation of tamoxifen and alpha-hydroxytamoxifen to DNA- binding species in rat hepatocytes proceeds via sulphation

1998 • 61 citations

Does tamoxifen cause cancer in humans?

1998 • 60 citations

Lack of evidence from HPLC 32P-post-labelling for tamoxifenDNA adducts in the human endometrium

1999 • 58 citations

The deuterium isotope effect for the α-hydroxylation of tamoxifen by rat liver microsomes accounts for the reduced genotoxicity of [D₅-ethyl]tamoxifen

1995 • 53 citations

Comparison of the DNA adducts formed by tamoxifen and 4-hydroxytamoxifen in vivo

1999 • 50 citations

Aspects of metabolism of tamoxifen by rat liver microsomes

1986 • 43 citations

The mercenary business: ‘executive outcomes’

1997 • 41 citations

Evaluation of tamoxifen and alpha-hydroxytamoxifen 32P-post-labelled DNA adducts by the development of a novel automated on-line solid-phase extraction HPLC method

1998 • 38 citations

Minor products of reaction of DNA with alpha-acetoxytamoxifen

1997 • 33 citations

Miscoding Potential of Tamoxifen-Derived DNA Adducts: α-(N²-Deoxyguanosinyl)tamoxifen

1997 • 31 citations

Lifetime and Reactivity of an Ultimate Tamoxifen Carcinogen: The Tamoxifen Carbocation

1998 • 24 citations

Tamoxifen−DNA Adducts Formed by α-Acetoxytamoxifen N-Oxide

1999 • 17 citations