Synthesis and Reactivity of a Potential Carcinogenic Metabolite of Tamoxifen: 3,4-Dihydroxytamoxifen-o-quinone

Semiquinone anion radicals from addition of amino acids, peptides, and proteins to quinones derived from oxidation of catechols and catecholamines. An ESR spin stabilization study.

1987 • 151 citations

Hard acid and soft nucleophile system. 2. Demethylation of methyl ethers of alcohol and phenol with an aluminum halide-thiol system

1980 • 145 citations

Evidence That 4-Allyl-o-quinones Spontaneously Rearrange to Their More Electrophilic Quinone Methides: Potential Bioactivation Mechanism for the Hepatocarcinogen Safrole

1994 • 127 citations

Boron trihalide-methyl sulfide complexes as convenient reagents for dealkylation of aryl ethers

1980 • 97 citations

Facile geometric isomerization of phenolic non-steroidal estrogens and antiestrogens: Limitations to the interpretation of experiments characterizing the activity of individual isomers

1985 • 89 citations

Regiospecific attack of nitrogen and sulfur nucleophiles on quinones derived from poison oak/ivy catechols (urushiols) and analogs as models for urushiol-protein conjugate formation

1981 • 75 citations

Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins.

1999 • 68 citations

New Highly Stereoselective Synthesis of (Z)-4-Hydroxytamoxifen and (Z)-4-Hydroxytoremifene via McMurry Reaction

1996 • 67 citations

Antiestrogenic and antifertility compounds. 4. 1,1,2-Triarylalkan-1-ols and 1,1,2-triarylalk-1-enes containing basic ether groups

1971 • 51 citations

Stereochemistry and Reactions with Hydroxyl Ion and with Silver Oxide of the 2-Bromo-4-phenylcyclohexanols and the 1-Methyl-2-bromo-4-phenylcyclohexanols¹

1960 • 30 citations

DNA fragmentation during exposure of rat cerebella to ethanol under hypoxia imposedin vitro

1999 • 21 citations

Permethyl analog of the pyrrolic antibiotic distamycin A

1981 • 20 citations

Selective removal of an aromatic methylenedioxy group

1976 • 16 citations

DNA cleavage and 8-hydroxydeoxyguanosine formation caused by tamoxifen derivatives in vitro

1998 • 15 citations

Rational design of irinotecan administration based on preclinical models.

1998 • 11 citations

Identification of epoxide metabolites of tamoxifen by on-line liquid chromatography-electrospray ionization mass spectrometry

1994 • 3 citations

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