Expression of Activated Epidermal Growth Factor Receptors, Ras-Guanosine Triphosphate, and Mitogen-activated Protein Kinase in Human Glioblastoma Multiforme Specimens

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1997 • 2,746 citations

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo

1992 • 2,293 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer.

1996 • 1,393 citations

Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment.

1998 • 1,086 citations

Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts.

1998 • 1,013 citations

A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity.

1994 • 932 citations

Structural alterations of the epidermal growth factor receptor gene in human gliomas.

1992 • 853 citations

Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors.

1995 • 633 citations

Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas.

1990 • 593 citations

The Enhanced Tumorigenic Activity of a Mutant Epidermal Growth Factor Receptor Common in Human Cancers Is Mediated by Threshold Levels of Constitutive Tyrosine Phosphorylation and Unattenuated Signaling

1997 • 591 citations

Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.

1993 • 565 citations

Expression of epidermal growth factor receptors in human brain tumors.

1984 • 478 citations

Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas.

1995 • 465 citations

DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3–26.1 is deleted in malignant brain tumours

1997 • 444 citations

Her-2/neu expression in node-negative breast cancer: direct tissue quantitation by computerized image analysis and association of overexpression with increased risk of recurrent disease.

1993 • 432 citations

A common mutant epidermal growth factor receptor confers enhanced tumorigenicity on human glioblastoma cells by increasing proliferation and reducing apoptosis.

1996 • 407 citations

Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma.

1990 • 384 citations

Proliferation of human malignant astrocytomas is dependent on Ras activation

1997 • 331 citations

Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts.

1990 • 329 citations

The p53 Gene and Protein in Human Brain Tumors

1994 • 303 citations

Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop

1995 • 298 citations

Functional characterization of an EGF receptor with a truncated extracellular domain expressed in glioblastomas with EGFR gene amplification.

1994 • 255 citations

Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas.

1993 • 246 citations

Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors.

1988 • 218 citations

Gene Amplification in Malignant Human Gliomas: Clinical and Histopathologic Aspects

1988 • 216 citations

Transformational and altered signal transduction by a naturally occurring mutant EGF receptor.

1996 • 195 citations

A tiger behind many doors: multiple genetic pathways to malignant glioma

1995 • 187 citations

Loss of tumorigenicity of rat glioblastoma directed by episome-based antisense cDNA transcription of insulin-like growth factor I.

1992 • 180 citations

Enhanced Tumorigenic Behavior of Glioblastoma Cells Expressing a Truncated Epidermal Growth Factor Receptor Is Mediated through the Ras-Shc-Grb2 Pathway

1996 • 175 citations

Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells.

1993 • 155 citations

Ras-GTP levels are elevated in human NF1 peripheral nerve tumors.

1996 • 144 citations

Loss of P16INK4 expression is frequent in high grade gliomas.

1995 • 120 citations

Activation of the Ras/Mitogen-Activated Protein Kinase Pathway by Kinase-Defective Epidermal Growth Factor Receptors Results in Cell Survival but Not Proliferation

1998 • 115 citations

Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors.

1996 • 112 citations

Determination of absolute amounts of GDP and GTP bound to Ras in mammalian cells: comparison of parental and Ras-overproducing NIH 3T3 fibroblasts.

1995 • 97 citations

A naturally occurring mutant human epidermal growth factor receptor as a target for peptide vaccine immunotherapy of tumors.

1997 • 89 citations

Retinoblastoma gene deletions in human glioblastomas.

1991 • 89 citations

Differential Modulation of Mitogen-activated Protein (MAP) Kinase/Extracellular Signal-related Kinase Kinase and MAP Kinase Activities by a Mutant Epidermal Growth Factor Receptor

1995 • 87 citations

Expression of an altered epidermal growth factor receptor by human glioblastoma cells.

1988 • 68 citations

Expression of growth factor receptors in human brain tumours

1991 • 68 citations

Specific targeting of a mutant, activated egf receptor found in glioblastoma using a monoclonal antibody

1995 • 67 citations

Improved targeting of an anti-epidermal growth factor receptor variant III monoclonal antibody in tumor xenografts after labeling using N-succinimidyl 5-iodo-3-pyridinecarboxylate.

1997 • 63 citations

Inhibition of a naturally occurring EGFR oncoprotein by the p185neu ectodomain: implications for subdomain contributions to receptor assembly

1998 • 54 citations

Gene amplification as a prognostic factor in primary brain tumors.

1998 • 52 citations

In vitro and in vivo behavior of radiolabeled chimeric anti-EGFRvIII monoclonal antibody: Comparison with its murine parent

1997 • 44 citations

Monoclonal antibody against the fusion junction of a deletion-mutant epidermal growth factor receptor

1996 • 37 citations

Tandem duplication of the epidermal growth factor receptor tyrosine kinase and calcium internalization domains in A-172 glioma cells

1998 • 37 citations

Expression of an oncogenic mutant EGF receptor markedly increases the sensitivity of cells to an EGF‐receptor‐specific antibody‐toxin

1998 • 30 citations

Expression of platelet derived growth factor and platelet derived growth factor receptor mRNA in a glioblastoma from a patient with Li-Fraumeni syndrome.

1995 • 26 citations

Expression of an oncogenic mutant EGF receptor markedly increases the sensitivity of cells to an EGF-receptor-specific antibody-toxin

1998 • 21 citations