Conformational Dynamics of the Chromatin Fiber in Solution: Determinants, Mechanisms, and Functions

Translating the Histone Code

2001 • 9,488 citations

Crystal structure of the nucleosome core particle at 2.8 Å resolution

1997 • 8,906 citations

The language of covalent histone modifications

2000 • 8,260 citations

Histone Acetyltransferases

2001 • 1,745 citations

Involvement of histone H1 in the organization of the nucleosome and of the salt-dependent superstructures of chromatin.

1979 • 1,532 citations

ALTERATION OF NUCLEOSOME STRUCTURE AS A MECHANISM OF TRANSCRIPTIONAL REGULATION

1998 • 1,124 citations

Chromatin Structure and Function

1979 • 1,050 citations

Signaling to Chromatin through Histone Modifications

2000 • 987 citations

Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: A molecular model for the formation of heterochromatin in yeast

1995 • 778 citations

Preparation of nucleosome core particle from recombinant histones

1999 • 770 citations

Crystal structure of globular domain of histone H5 and its implications for nucleosome binding

1993 • 739 citations

The nucleosomal core histone octamer at 3.1 A resolution: a tripartite protein assembly and a left-handed superhelix.

1991 • 720 citations

Histone methylation versus histone acetylation: new insights into epigenetic regulation

2001 • 689 citations

Mechanism of Protein Access to Specific DNA Sequences in Chromatin: A Dynamic Equilibrium Model for Gene Regulation

1995 • 651 citations

Dynamic binding of histone H1 to chromatin in living cells

2000 • 606 citations

Structure of the chromatosome, a chromatin particle containing 160 base pairs of DNA and all the histones

1978 • 583 citations

Nucleosomes, linker DNA, and linker histone form a unique structural motif that directs the higher-order folding and compaction of chromatin

1998 • 574 citations

Disruption of Higher-Order Folding by Core Histone Acetylation Dramatically Enhances Transcription of Nucleosomal Arrays by RNA Polymerase III

1998 • 568 citations

Chromatin disruption and modification

1999 • 537 citations

Crystal structure of a nucleosome core particle containing the variant histone H2A.Z.

2000 • 513 citations

The histone tails of the nucleosome

1998 • 512 citations

Chromatin reconstituted from tandemly repeated cloned DNA fragments and core histones: A model system for study of higher order structure

1985 • 469 citations

Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4.

1996 • 460 citations

Pulling a single chromatin fiber reveals the forces that maintain its higher-order structure

2000 • 453 citations

Chromatin Structure and Function

1999 • 438 citations

Control of Cell Division by Very Lysine Rich Histone (F1) Phosphorylation

1974 • 429 citations

Studies of the DNA binding properties of histone H4 amino terminus. Thermal denaturation studies reveal that acetylation markedly reduces the binding constant of the H4 “tail” to DNA.

1993 • 423 citations

Rapid exchange of histone H1.1 on chromatin in living human cells

2000 • 405 citations

Histone variant H2A.Z is required for early mammalian development

2001 • 373 citations

The histone fold: a ubiquitous architectural motif utilized in DNA compaction and protein dimerization.

1995 • 351 citations

Review: Chromatin Structural Features and Targets That Regulate Transcription

2000 • 348 citations

25 years after the nucleosome model: chromatin modifications

2000 • 338 citations

Topography of the histone octamer surface: repeating structural motifs utilized in the docking of nucleosomal DNA.

1993 • 333 citations

Visualization of G1 chromosomes: a folded, twisted, supercoiled chromonema model of interphase chromatid structure.

1994 • 331 citations

Use of selectively trypsinized nucleosome core particles to analyze the role of the histone “tails” in the stabilization of the nucleosome

1989 • 330 citations

Boundary analysis of sedimentation‐velocity experiments with monodisperse and paucidisperse solutes

1978 • 311 citations

Modulation of Chromatin Folding by Histone Acetylation

1995 • 311 citations

Roles of H1 domains in determining higher order chromatin structure and H1 location

1986 • 310 citations

DNA binding within the nucleosome core

1998 • 298 citations

Higher-order structure of chromatin and chromosomes

2001 • 291 citations

Sequence and position-dependence of the equilibrium accessibility of nucleosomal DNA target sites 1 1Edited by T. Richmond

2000 • 289 citations

STRUCTURE, DYNAMICS, AND FUNCTION OF CHROMATIN IN VITRO

1998 • 281 citations

Influence of histone H1 on chromatin structure

1977 • 278 citations

Chromatin remodeling enzymes: who's on first?

2001 • 265 citations

Electrostatic mechanism of chromatin folding

1990 • 259 citations

The essential histone variant H2A.Z regulates the equilibrium between different chromatin conformational states

2002 • 253 citations

A Model for the Cooperative Binding of Eukaryotic Regulatory Proteins to Nucleosomal Target Sites

1996 • 251 citations

Reversible Oligonucleosome Self-Association: Dependence on Divalent Cations and Core Histone Tail Domains

1996 • 250 citations

Change in the pattern of histone binding to DNA upon transcriptional activation

1989 • 246 citations

Structure and Function of the Core Histone N-Termini: More Than Meets the Eye

1998 • 241 citations

Linker Histones Stabilize the Intrinsic Salt-Dependent Folding of Nucleosomal Arrays: Mechanistic Ramifications for Higher-Order Chromatin Folding

1998 • 240 citations

Role of the histone “tails” in the folding of oligonucleosomes depleted of histone H1.

1992 • 238 citations

Three-dimensional structure of extended chromatin fibers as revealed by tapping-mode scanning force microscopy.

1994 • 236 citations

Changes in chromatin folding in solution

1980 • 235 citations

Global Role for Chromatin Remodeling Enzymes in Mitotic Gene Expression

2000 • 232 citations

Homogeneous reconstituted oligonucleosomes, evidence for salt-dependent folding in the absence of histone H1

1989 • 224 citations

Physicochemical studies of the folding of the 100 Å nucleosome filament into the 300 Å filament

1986 • 224 citations

Histone H1: location and role

1999 • 212 citations

Regions of variant histone His2AvD required for Drosophila development

1999 • 207 citations

A variety of DNA-binding and multimeric proteins contain the histone fold motif

1995 • 202 citations

What does ‘chromatin remodeling’ mean?

2000 • 197 citations

Histone H3 N-terminal mutations allow hyperactivation of the yeast GAL1 gene in vivo.

1992 • 186 citations

Catalytic activity of the yeast SWI/SNF complex on reconstituted nucleosome arrays

1997 • 184 citations

Salt-induced release of DNA from nucleosome core particles

1989 • 183 citations

Large-scale chromatin decondensation and recondensation regulated by transcription from a natural promoter

2001 • 181 citations

Magnetic Resonance Studies of Deoxyribonucleoprotein

1973 • 179 citations

Core Histone Tail Domains Mediate Oligonucleosome Folding and Nucleosomal DNA Organization through Distinct Molecular Mechanisms

1995 • 173 citations

HISTONE STRUCTURE AND THE ORGANIZATION OF THE NUCLEOSOME

1997 • 171 citations

Linker histones H1 and H5 prevent the mobility of positioned nucleosomes.

1994 • 168 citations

Chromatin conformation and salt-induced compaction: three-dimensional structural information from cryoelectron microscopy.

1995 • 165 citations

Formation and stability of higher order chromatin structures. Contributions of the histone octamer.

1994 • 163 citations

Energy-dependent chromatin accessibility and nucleosome mobility in a cell-free system.

1995 • 162 citations

Chromatin Higher Order Structure: Chasing a Mirage?

1995 • 161 citations

Proteases as structural probes for chromatin: The domain structure of histones

1984 • 160 citations

The Nucleosomal Array: Structure/Function Relationships

1996 • 155 citations

Acetylation Increases the α-Helical Content of the Histone Tails of the Nucleosome

2000 • 152 citations

Errata: The essential histone variant H2A.Z regulates the equilibrium between different chromatin conformational states

2002 • 152 citations

Role of Histone Acetylation in the Assembly and Modulation of Chromatin Structures

2001 • 150 citations

DNA folding by histones: The kinetics of chromatin core particle reassembly and the interaction of nucleosomes with histones

1979 • 145 citations

Persistent Interactions of Core Histone Tails with Nucleosomal DNA following Acetylation and Transcription Factor Binding

1998 • 144 citations

Hybrid Trypsinized Nucleosomal Arrays: Identification of Multiple Functional Roles of the H2A/H2B and H3/H4 N-Termini in Chromatin Fiber Compaction

1997 • 141 citations

What do linker histones do in chromatin?

1997 • 139 citations

Toward A Unified Model Of Chromatin Folding

1989 • 139 citations

Histone H2A.Z Is Widely but Nonrandomly Distributed in Chromosomes of Drosophila melanogaster

2000 • 136 citations

Nucleosomes and the chromatin fiber

2001 • 136 citations

Large-scale chromatin structure and function

1999 • 129 citations

Nucleosome core particle stability and conformational change

1984 • 128 citations

The Core Histone N Termini Function Independently of Linker Histones during Chromatin Condensation

2000 • 126 citations

A highly basic histone H4 domain bound to the sharply bent region of nucleosomal DNA

1988 • 123 citations

Histone H1 and Chromatin Higher-Order Structure

1997 • 122 citations

Effects of core histone tail domains on the equilibrium constants for dynamic dna site accessibility in nucleosomes

2000 • 120 citations

Localization of the sites along nucleosome DNA which interact with NH2-terminal histone regions.

1977 • 119 citations

Histone acetylation alters the capacity of the H1 histones to condense transcriptionally active/competent chromatin.

1990 • 116 citations

MENT, a Heterochromatin Protein That Mediates Higher Order Chromatin Folding, Is a New Serpin Family Member

1999 • 114 citations

Chromatin Fiber Structure: Morphology, Molecular Determinants, Structural Transitions

1998 • 110 citations

Computational Modeling Predicts the Structure and Dynamics of Chromatin Fiber

2001 • 106 citations

Preferential interaction of the core histone tail domains with linker DNA

2001 • 104 citations

Chromatin organization re-viewed

1995 • 103 citations

Effects of Histone Acetylation on the Solubility and Folding of the Chromatin Fiber

2001 • 98 citations

Dynamics and equilibria of nucleosomes at elevated ionic strength.

1984 • 97 citations

Involvement of the domains of histones H1 and H5 in the structural organization of soluble chromatin

1983 • 96 citations

Condensation of chromatin: role of multivalent cations

1986 • 95 citations

Functional interaction between GCN5 and polyamines: a new role for core histone acetylation

1999 • 94 citations

The location of the linker histone on the nucleosome

1999 • 94 citations

Influence of chromatin folding on transcription initiation and elongation by RNA polymerase III

1992 • 92 citations

Pulling chromatin fibers: computer simulations of direct physical micromanipulations

2000 • 92 citations

The mechanism of nucleosome assembly onto oligomers of the sea urchin 5 S DNA positioning sequence

1991 • 91 citations

Human DNA ligase I efficiently seals nicks in nucleosomes

2000 • 91 citations

Structure and Dynamic Properties of a Glucocorticoid Receptor-Induced Chromatin Transition

2000 • 90 citations

Assembly of defined nucleosomal and chromatin arrays from pure components

1999 • 89 citations

Chromatin structure: Linking structure to function with histone H1

1998 • 85 citations

A role for histones H2A/H2B in chromatin folding and transcriptional repression.

1994 • 84 citations

Histone hyperacetylation has little effect on the higher order folding of chromatin

1983 • 83 citations

Binding of daunomycin to calf thymus nucleosomes

1983 • 82 citations

Distribution of high mobility group proteins 1/2,E and 14/17 and linker histones H1 and H5 on transcribed and non-transcribed regions of chicken erythrocyte chromatin

1991 • 82 citations

Photofootprint of nucleosome core DNA in intact chromatin having different structural states

1988 • 78 citations

The histone core exerts a dominant constraint on the structure of DNA in a nucleosome

1991 • 78 citations

Where is the globular domain of linker histone located on the nucleosome?

1997 • 78 citations

Linker Histone Tails and N-Tails of Histone H3 Are Redundant: Scanning Force Microscopy Studies of Reconstituted Fibers

1998 • 78 citations

The organized chromatin domain of the repressed yeast a cell-specific gene STE6 contains two molecules of the corepressor Tup1p per nucleosome

2000 • 77 citations

Histone H1 Is a Specific Repressor of Core Histone Acetylation in Chromatin

2000 • 77 citations

The N tails of histones H3 and H4 adopt a highly structured conformation in the nucleosome 1 1Edited by T. Richmond

1997 • 77 citations

Chromatin core particle unfolding induced by tryptic cleavage of histones

1977 • 75 citations

The Core Histone N-Terminal Domains Are Required for Multiple Rounds of Catalytic Chromatin Remodeling by the SWI/SNF and RSC Complexes

1999 • 75 citations

Rearrangement of the histone H2A C-terminal domain in the nucleosome.

1994 • 75 citations

Reversible and irreversible changes in nucleosome structure along the c-fos and c-myc oncogenes following inhibition of transcription

1990 • 74 citations

Differential dissociation of histone tails from core chromatin

1984 • 74 citations

Assembly and structural properties of subsaturated chromatin arrays.

1993 • 73 citations

Treatment with sodium butyrate inhibits the complete condensation of interphase chromatin

1988 • 68 citations

Major Role of the Histones H3-H4 in the Folding of the Chromatin Fiber

1997 • 67 citations

Histone H1

1997 • 66 citations

The chromatin unfolding domain of chromosomal protein HMG-14 targets the N-terminal tail of histone H3 in nucleosomes

1998 • 64 citations

Assembly, Remodeling, and Histone Binding Capabilities of Yeast Nucleosome Assembly Protein 1

1998 • 63 citations

The N-terminal tail of histone H2A binds to two distinct sites within the nucleosome core

1997 • 62 citations

Sir3-dependent assembly of supramolecular chromatin structuresin vitro

2001 • 62 citations

Linker DNA and H1-Dependent Reorganization of Histone−DNA Interactions within the Nucleosome

1998 • 60 citations

Hydrodynamic studies of the interaction between nucleosome core particles and core histones

1981 • 60 citations

Chromatin Structure in Granulocytes

1998 • 55 citations

Histone-DNA contacts in a nucleosome core containing a Xenopus 5S rRNA gene

1993 • 55 citations

Nuclear Visions Functional Flexibility from Structural Instability

2001 • 53 citations

Chromatin Structure Revisited

1999 • 51 citations

Evidence for Nonrandom Behavior in 208-12 Subsaturated Nucleosomal Array Populations Analyzed by AFM

1999 • 50 citations

Gene silencing: Two faces of SIR2

2000 • 42 citations

Magnesium-dependent Association and Folding of Oligonucleosomes Reconstituted with Ubiquitinated H2A

2001 • 40 citations

How do linker histones mediate differential gene expression?

1999 • 40 citations

Quantitative Analysis of Macromolecular Conformational Changes Using Agarose Gel Electrophoresis: Application to Chromatin Folding

1994 • 39 citations

Silent chromatin in yeast: an orchestrated medley featuring Sir3p

1998 • 39 citations

Nuclear‐Magnetic Resonance and Optical‐Spectroscopic Studies of Conformation and Interactions in the Cleaved Halves of Histone F2B

1972 • 35 citations

Linker histone function in chromatin: Dual mechanisms of action

2001 • 32 citations

Nucleosome Motion: Evidence and Models

1985 • 32 citations

Enhanced transcription factor access to arrays of histone H3/H4 tetramer⋅DNA complexes in vitro : Implications for replication and transcription

1998 • 31 citations

Equilibrium and Dynamic Nucleosome Stability

2003 • 29 citations

Structural States of the Nucleosome

1996 • 29 citations

Self-Association of Linker Histone H5 and of Its Globular Domain: Evidence for Specific Self-Contacts

1998 • 29 citations

The Mouse Mammary Tumor Virus Promoter Adopts Distinct Chromatin Structures in Human Breast Cancer Cells with and without Glucocorticoid Receptor

2000 • 27 citations

Asymmetric Linker Histone Association Directs the Asymmetric Rearrangement of Core Histone Interactions in a Positioned Nucleosome Containing a Thyroid Hormone Response Element

1998 • 27 citations

DNA Lesion Bypass Polymerases Open Up

2001 • 25 citations

Structure of the Histone Octamer Core of the Nucleosome and Its Potential Interactions with DNA

1993 • 22 citations

Order and disorder in 30 nm chromatin fibers

1992 • 21 citations

Analysis of Chromatin by Scanning Force Microscopy

2003 • 20 citations

Self-association of the globular domain of histone H5

1994 • 19 citations

Analysis of the changes in the structure and hydration of the nucleosome core particle at moderate ionic strengths

1990 • 17 citations

High resolution microanalysis and three-dimensional nucleosome structure associated with transcribing chromatin

1997 • 17 citations

Linker histone function in chromatin: Dual mechanisms of action

2001 • 4 citations

Are linker histones (histone H1) dispensable for survival?

2000 • 3 citations

Higher-order folding of heterochromatin: Protein bridges span the nucleosome arrays

2001 • 1 citations