HISTONE STRUCTURE AND THE ORGANIZATION OF THE NUCLEOSOME

A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

1996 • 1,769 citations

Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation

1996 • 1,567 citations

Involvement of histone H1 in the organization of the nucleosome and of the salt-dependent superstructures of chromatin.

1979 • 1,532 citations

Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5

1993 • 1,269 citations

Solenoidal model for superstructure in chromatin.

1976 • 1,223 citations

A positive role for histone acetylation in transcription factor access to nucleosomal DNA

1993 • 1,116 citations

Crystal Structure of a CAP-DNA Complex: the DNA Is Bent by 90°

1991 • 1,109 citations

Structure of the nucleosome core particle at 7 Å resolution

1984 • 1,028 citations

Sequence periodicities in chicken nucleosome core DNA

1986 • 930 citations

Stimulation of GAL4 Derivative Binding to Nucleosomal DNA by the Yeast SWI/SNF Complex

1994 • 853 citations

Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.

1993 • 795 citations

Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: A molecular model for the formation of heterochromatin in yeast

1995 • 778 citations

Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex

1994 • 766 citations

Crystal structure of globular domain of histone H5 and its implications for nucleosome binding

1993 • 739 citations

The nucleosomal core histone octamer at 3.1 A resolution: a tripartite protein assembly and a left-handed superhelix.

1991 • 720 citations

DNA bending and its relation to nucleosome positioning

1985 • 702 citations

The structure of histone H1 and its location in chromatin

1980 • 696 citations

Action of micrococcal nuclease on chromatin and the location of histone H1

1977 • 686 citations

DNA recognition by GAL4: structure of a protein-DNA complex

1992 • 664 citations

ATP-dependent nucleosome disruption at a heat-shock promoter mediated by binding of GAGA transcription factor

1994 • 662 citations

Mechanism of Protein Access to Specific DNA Sequences in Chromatin: A Dynamic Equilibrium Model for Gene Regulation

1995 • 651 citations

Chromatin

1989 • 606 citations

Purification and properties of an ATP-dependent nucleosome remodeling factor

1995 • 600 citations

Facilitated binding of TATA-binding protein to nucleosomal DNA

1994 • 593 citations

Structure of the chromatosome, a chromatin particle containing 160 base pairs of DNA and all the histones

1978 • 583 citations

Gene number, noise reduction and biological complexity

1995 • 462 citations

Repression and activation by multiprotein complexes that alter chromatin structure.

1996 • 444 citations

Histone acetylation reduces nucleosome core particle linking number change

1989 • 394 citations

Sequence-Specific Antirepression of Histone H1-Mediated Inhibition of Basal RNA Polymerase II Transcription

1991 • 378 citations

ISWI, a member of the SWl2/SNF2 ATPase family, encodes the 140 kDa subunit of the nucleosome remodeling factor

1995 • 366 citations

The histone core complex: an octamer assembled by two sets of protein-protein interactions

1978 • 357 citations

Reversible histone modification and the chromosome cell cycle

1992 • 357 citations

Histone Function in Transcription

1990 • 354 citations

The structure of DNA in a nucleosome.

1990 • 353 citations

The histone fold: a ubiquitous architectural motif utilized in DNA compaction and protein dimerization.

1995 • 351 citations

Artificial nucleosome positioning sequences.

1989 • 347 citations

Identification of a Gene Encoding a Yeast Histone H4 Acetyltransferase

1995 • 341 citations

An active tissue-specific enhancer and bound transcription factors existing in a precisely positioned nucleosomal array

1993 • 336 citations

Topography of the histone octamer surface: repeating structural motifs utilized in the docking of nucleosomal DNA.

1993 • 333 citations

Structural features of a phased nucleosome core particle.

1983 • 323 citations

[33] Hydroxyl radical footprinting: A high-resolution method for mapping protein-DNA contacts

1987 • 322 citations

Hormone induces binding of receptors and transcription factors to a rearranged nucleosome on the MMTV promoter in vivo.

1995 • 313 citations

Roles of H1 domains in determining higher order chromatin structure and H1 location

1986 • 310 citations

Mobile nucleosomes--a general behavior.

1992 • 309 citations

Studies on the Role and Mode of Operation of the Very‐Lysine‐Rich Histone H1 in Eukaryote Chromatin

1977 • 309 citations

A low resolution structure for the histone core of the nucleosome

1980 • 309 citations

The transcriptional regulation of Xenopus 5S RNA genes in chromatin: The roles of active stable transcription complexes and histone H1

1984 • 265 citations

Structural similarity between TAFs and the heterotetrameric core of the histone octamer

1996 • 258 citations

Histone contributions to the structure of DNA in the nucleosome.

1991 • 256 citations

Histone-h1-dependent chromatin superstructures and the suppression of gene activity

1984 • 251 citations

Nucleosome Positioning: Occurrence, Mechanisms, and Functional Consequences

1991 • 248 citations

Chromatin condensation: does histone H1 dephosphorylation play a role?

1992 • 247 citations

The winged-helix DNA-binding motif: Another helix-turn-helix takeoff

1993 • 242 citations

Transcription: In tune with the histones

1994 • 239 citations

A histone octamer can step around a transcribing polymerase without leaving the template

1994 • 238 citations

SPKK, a new nucleic acid-binding unit of protein found in histone.

1989 • 237 citations

Developmental Regulation of Two 5 S Ribosomal RNA Genes

1988 • 229 citations

Structural analysis of a triple complex between the histone octamer, a Xenopus gene for 5S RNA and transcription factor IIIA.

1985 • 222 citations

A nucleosome-dependent static loop potentiates estrogen-regulated transcription from the Xenopus vitellogenin B1 promoter in vitro.

1993 • 219 citations

Mobility of positioned nucleosomes on 5 S rDNA

1991 • 211 citations

A variety of DNA-binding and multimeric proteins contain the histone fold motif

1995 • 202 citations

Protein motifs that recognize structural features of DNA

1991 • 200 citations

Nucleosomes: regulators of transcription

1990 • 186 citations

‘SPKK’ motifs prefer to bind to DNA at A/T-rich sites.

1989 • 184 citations

A histone octamer-like structure within TFIID

1996 • 182 citations

DNA and protein determinants of nucleosome positioning on sea urchin 5S rRNA gene sequences in vitro.

1990 • 176 citations

Mapping nucleosome position at single base-pair resolution by using site-directed hydroxyl radicals.

1996 • 175 citations

Removal of histone H1 exposes a fifty base pair DNA segment between nucleosomes

1976 • 175 citations

A positive role for nucleosome mobility in the transcriptional activity of chromatin templates: restriction by linker histones.

1995 • 172 citations

The influence of DNA and nucleosome structure on integration events directed by HIV integrase.

1994 • 172 citations

Linker Histone-dependent DNA Structure in Linear Mononucleosomes

1996 • 171 citations

Nucleosome positioning on the MMTV LTR results from the frequency-biased occupancy of multiple frames.

1995 • 171 citations

Overcoming a nucleosomal barrier to transcription

1995 • 168 citations

Linker histones H1 and H5 prevent the mobility of positioned nucleosomes.

1994 • 168 citations

Alpha-helix in the carboxy-terminal domains of histones H1 and H5.

1988 • 159 citations

A nucleosome core is transferred out of the path of a transcribing polymerase

1992 • 155 citations

Crystallographic Structure of the Octameric Histone Core of the Nucleosome at a Resolution of 3.3 Å

1985 • 155 citations

Identification of two DNA-binding sites on the globular domain of histone H5.

1996 • 150 citations

Preferential and asymmetric interaction of linker histones with 5S DNA in the nucleosome.

1993 • 149 citations

The Conformation of Histone H5

1978 • 148 citations

Points of contact between histone H1 and the histone octamer.

1980 • 145 citations

NMR Structure of HMfB from the Hyperthermophile,Methanothermus fervidus, Confirms that this Archaeal Protein is a Histone

1996 • 144 citations

HMG-D, the Drosophila melanogaster homologue of HMG 1 protein, is associated with early embryonic chromatin in the absence of histone H1.

1994 • 138 citations

A nucleosome precludes binding of the transcription factor Pho4 in vivo to a critical target site in the PHO5 promoter.

1994 • 134 citations

Chromatosome positioning on assembled long chromatin

1991 • 133 citations

Primary organization of the nucleosome core particles sequential arrangement of histones along DNA

1980 • 133 citations

Nucleosome Structural Changes Due to Acetylation

1994 • 133 citations

Nucleosome linking number change controlled by acetylation of histones H3 and H4.

1990 • 132 citations

Nucleosome positioning is determined by the (H3-H4)2 tetramer.

1991 • 127 citations

Histones H2A/H2B inhibit the interaction of transcription factor IIIA with the Xenopus borealis somatic 5S RNA gene in a nucleosome.

1992 • 123 citations

Identification of a non-basic domain in the histone H4 N-terminus required for repression of the yeast silent mating loci.

1992 • 120 citations

Interaction of the histone (H3-H4)2 tetramer of the nucleosome with positively supercoiled DNA minicircles: Potential flipping of the protein from a left- to a right-handed superhelical form.

1996 • 117 citations

Footprinting of linker histones H5 and H1 on the nucleosome.

1988 • 116 citations

DNA binding by the archaeal histone HMf results in positive supercoiling.

1991 • 111 citations

Interplay between chromatin structure and transcription

1995 • 110 citations

Developmentally regulated expression of linker‐histone variants in vertebrates

1994 • 103 citations

The Linker Histones and Chromatin Structure: New Twists

1996 • 98 citations

Cooperative binding of the globular domains of histones H1 and H5 to DNA

1992 • 97 citations

Involvement of the domains of histones H1 and H5 in the structural organization of soluble chromatin

1983 • 96 citations

Homo- and Heteronuclear Two-Dimensional NMR Studies of the Globular Domain of Histone H1: Full Assignment, Tertiary Structure, and Comparison with the Globular Domain of Histone H5

1994 • 96 citations

Another potential artifact in the study of nucleosome phasing by chromatin digestion with micrococcal nuclease

1983 • 96 citations

The polypeptide fold of the globular domain of histone H5 in solution. A study using nuclear magnetic resonance, distance geometry and restrained molecular dynamics.

1987 • 86 citations

Contacts of the globular domain of histone H5 and core histones with DNA in a "chromatosome".

1994 • 81 citations

The higher order structure of chromatin and histone H1

1984 • 81 citations

Binding of histones H1 and H5 and their globular domains to four-way junction DNA.

1994 • 80 citations

The histone core exerts a dominant constraint on the structure of DNA in a nucleosome

1991 • 78 citations

Crystals of a nucleosome core particle containing defined sequence DNA

1988 • 78 citations

Site-Directed Cleavage of DNA by a Linker Histone−Fe(II) EDTA Conjugate: Localization of a Globular Domain Binding Site within a Nucleosome

1996 • 77 citations

Hyperacetylation of core histones does not cause unfolding of nucleosomes. Neutron scatter data accords with disc shape of the nucleosome.

1986 • 75 citations

Preferential binding of histone H1 to four-way helical junction DNA.

1993 • 70 citations

The role of a positioned nucleosome at the Drosophila melanogaster hsp26 promoter.

1995 • 62 citations

Effects of histone acetylation on chromatin topology in vivo.

1992 • 62 citations

Thermodynamic studies of the core histones: Ionic strength and pH dependence of H2A-H2B dimer stability

1995 • 58 citations

Co-operative binding of the globular domain of histone H5 to DNA

1992 • 58 citations

DNA Sequence Organization in Chromatosomes

1994 • 53 citations

Chromatin superstructure-dependent crosslinking with DNA of the histone H5 residues Thr1, His25 and His62

1990 • 49 citations

Selective radiolabelling and identification of a strong nucleosome binding site on the globular domain of histone H5.

1986 • 48 citations

Histones H1 and H5 interact preferentially with crossovers of double-helical DNA.

1993 • 47 citations

Interaction of f1 histone with superhelical DNA.

1975 • 47 citations

Studies of Nucleosome Structure

1993 • 46 citations

Binding of the globular domain of linker histones H5/H1 to the nucleosome: a hypothesis

1989 • 35 citations

Alterations in Nucleosome Core Structure in Linker Histone-depleted Chromatin

1996 • 31 citations

X-ray Diffraction Analysis of Crystals Containing Twofold Symmetric Nucleosome Core Particles

1996 • 31 citations

An NMR study on the DNA-binding SPKK motif and a model for its interaction with DNA

1993 • 28 citations

Deposition of histone H1 onto reconstituted nucleosome arrays inhibits both initiation and elongation of transcripts by 17 RNA polymerase

1995 • 28 citations

The Octameric Histone Core of the Nucleosome

1994 • 27 citations

Mapping of histone H5 sites on nucleosomes using immunoelectron microscopy.

1983 • 27 citations

Chromatin: Pushing nucleosomes around

1996 • 25 citations

DNA Sequence Patterns in Precisely Positioned Nucleosomes

1988 • 24 citations

Structure of the Histone Octamer Core of the Nucleosome and Its Potential Interactions with DNA

1993 • 22 citations

Regulation of Chromatin Condensation and Decondensation in Sea Urchin Pronuclei

1987 • 22 citations

Histone structure

1994 • 21 citations

Crystals of the Octameric Histone Core of the Nucleosome

1984 • 21 citations

Structure and Stability of Histone HMf from the Hyperthermophilic Archaeon Methanothermus fervidus

1995 • 18 citations

The histone fold: evolutionary questions.

1995 • 15 citations

Response : Crystallographic Structure of the Octamer Histone Core of the Nucleosome

1985 • 10 citations