Mixed Disulfides: Biological Functions and Increase in Oxidative Stress

10 Methoden der enzymatischen Analyse

2019 • 3,602 citations

The Glutathione Status of Cells

1978 • 1,218 citations

Glutathione: Metabolism and function

1978 • 971 citations

Enzymatic Synthesis of Deoxyribonucleotides

1964 • 917 citations

Thioredoxin catalyzes the reduction of insulin disulfides by dithiothreitol and dihydrolipoamide.

1979 • 907 citations

Toxic drug effects associated with oxygen metabolism: Redox cycling and lipid peroxidation

1981 • 650 citations

Functions of glutathione. Biochemical, physiological, toxicological and clinical aspects

1984 • 595 citations

Studies on the Reduction and Re-formation of Protein Disulfide Bonds

1961 • 595 citations

Regulation of the pentose phosphate cycle

1974 • 439 citations

The regulation of rat liver xanthine oxidase. Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzyme

1972 • 432 citations

Formation of three-dimensional structure in proteins. I. Rapid nonenzymic reactivation of reduced lysozyme

1970 • 394 citations

Identification and quantitation of glutathione in hepatic protein mixed disulfides and its relationship to glutathione disulfide

1983 • 353 citations

Thioredoxin and glutathione regulate photosynthesis in chloroplasts

1977 • 340 citations

Reduction of disulfides by thioredoxin. Exceptional reactivity of insulin and suggested functions of thioredoxin in mechanism of hormone action.

1979 • 324 citations

Bovine thioredoxin system. Purification of thioredoxin reductase from calf liver and thymus and studies of its function in disulfide reduction.

1977 • 294 citations

Free and protein-bound glutathione in normal and cataractous human lenses

1970 • 288 citations

Effects of Sulfhydryl Inhibition on Red Blood Cells

1966 • 287 citations

Hydroperoxide‐Metabolizing Systems in Rat Liver

1975 • 266 citations

Biological disulfides: the third messenger? Modulation of phosphofructokinase activity by thiol/disulfide exchange.

1982 • 265 citations

Redox control of enzyme activities by thiol/disulfide exchange

1984 • 264 citations

A mechanism of paraquat toxicity in mice and rats

1976 • 253 citations

Glutathione-dependent synthesis of deoxyribonucleotides. Purification and characterization of glutaredoxin from Escherichia coli.

1979 • 245 citations

Glutathione-dependent synthesis of deoxyribonucleotides. Characterization of the enzymatic mechanism of Escherichia coli glutaredoxin.

1979 • 239 citations

Insulin-stimulated intracellular hydrogen peroxide production in rat epididymal fat cells

1979 • 239 citations

Oxygen toxicity: augmentation of antioxidant defense mechanisms in rat lung

1976 • 216 citations

Evidence for the Involvement of Sulfhydryl Oxidation in the Regulation of Fat Cell Hexose Transport by Insulin

1974 • 209 citations

Glutathione dependent control of protein disulfide-sulfhydryl content by subcellular fractions of hepatic tissue

1977 • 182 citations

Catalysis by protein-disulphide isomerase of the unfolding and refolding of proteins with disulphide bonds

1980 • 173 citations

Structure and Function of the J Chain

1975 • 172 citations

Electrostatic influence of local cysteine environments on disulfide exchange kinetics

1981 • 167 citations

Hexose Transport in Isolated Brown Fat Cells

1974 • 159 citations

Role of cytoplasmic thioltransferase in cellular regulation by thiol-disulphide interchange

1980 • 154 citations

Flavins and flavoproteins

1977 • 144 citations

Dark modulation of NADP-dependent malate dehydrogenase and glucose-6-phosphate dehydrogenase in the chloroplast

1981 • 138 citations

Purification and characterization of cytoplasmic thioltransferase (glutathione:disulfide oxidoreductase) from rat liver

1978 • 133 citations

Reversible inactivation of guanylate cyclase by mixed disulfide formation.

1981 • 132 citations

Differential effects of sulfhydryl reagents on activation and deactivation of the fat cell hexose transport system.

1976 • 132 citations

Pathways of folding of reduced bovine pancreatic ribonuclease

1974 • 129 citations

Ozone interaction with rodent lung. III. Oxidation of reduced glutathione and formation of mixed disulfides between protein and nonprotein sulfhydryls.

1975 • 128 citations

Reduced nicotinamide adenine dinucleotide phosphate oxidase in adipocyte plasma membrane and its activation by insulin

1977 • 127 citations

Conformational changes associated with proteolytic processing of presecretory proteins allow glutathione-catalyzed formation of native disulfide bonds.

1982 • 125 citations

Increase in hepatic mixed disulphide and glutathione disulphide levels elicited by paraquat

1982 • 118 citations

Biosynthesis of immunoglobulin A (IgA) and immunoglobulin M (IgM). Requirement for J chain and a disulphide-exchanging enzyme for polymerization

1973 • 116 citations

Useful agents for the study of glutathione metabolism in erythrocytes. Organic hydroperoxides

1974 • 116 citations

Endogenous hydrogen peroxide and peroxidative metabolism in adipocytes in response to insulin and sulfhydryl reagents

1978 • 113 citations

Hepatic glutathione-insulin transhydrogenase.

1962 • 108 citations

How many distinct enzymes are responsible for the several cellular processes involving thiol:protein‐disulphide interchange?

1979 • 103 citations

Formation of interchain disulfide bonds and helical structure during biosynthesis of procollagen by embryonic tendon cells

1974 • 102 citations

The relevance of pentose phosphate pathway stimulation in rat lung to the mechanism of paraquat toxicity

1976 • 95 citations

Protein disulfide bond synthesis: a possible intracellular mechanism

1977 • 94 citations

Mode of Action of an Insulin-degrading Enzyme from Beef Liver

1962 • 93 citations

Cellular mixed disulphides between thiols and proteins, and their possible implication for radiation protection

1968 • 91 citations

Cyclic AMP-dependent control of the rat hepatic glutathione disulfide-sulfhydryl ratio

1977 • 89 citations

Some properties of mitochondrial glutathione

1975 • 86 citations

Preparation of Bovine Milk Xanthine Oxidase as a Dehydrogenase Form

1982 • 83 citations

Manipulation of the properties of enzymes by covalent attachment of carbohydrate

1978 • 82 citations

Inhibition of γ-glutamylcysteine synthetase by cystamine; An approach to a therapy of 5-oxoprolinuria (pyroglutamic aciduria)

1977 • 81 citations

The occurrence of protein-bound mixed disulfides in rat tissues

1973 • 81 citations

Relative contributions of thioltransferase-and thioredoxin-dependent systems in reduction of low-molecular-mass and protein disulphides

1983 • 78 citations

Studies on the Specificity and Mechanism of Action of Hepatic Glutathione-Insulin Transhydrogenase

1966 • 77 citations

Regulation of Rat Liver Glycogen Synthetase

1973 • 77 citations

The formation of mixed disulphides in rat lung following paraquat administration Correlation with changes in intermediary metabolism

1982 • 73 citations

Regulation of fructose diphosphatase activity by disulfide exchange.

1967 • 69 citations

A New Principle of Regulation of Enzymic Activity

1981 • 67 citations

Membrane thiol-disulfide status in glucose-6-phosphate dehydrogenase deficient red cells. Relationship to cellular glutathione

1982 • 62 citations

Oxidative-reductive modulation of guinea pig splenic cell guanylate cyclase activity.

1978 • 61 citations

Studies of the Insulin-like Actions of Thiols upon Isolated Fat Cells

1970 • 61 citations

Enzyme inactivation via disulphide–thiol exchange as catalysed by a rat liver membrane protein

1980 • 61 citations

Evidence of inactivation of pineal indoleamine N-acetyltransferase by protein thiol:disulfide exchange.

1980 • 61 citations

Inactivation of phosphorylase phosphatase by a factor from rabbit liver and its chemical characterization as glutathione disulfide.

1978 • 57 citations

Sensitivity of Hemoglobin Thiol Groups within Red Blood Cells of Rat during Oxidation of Glutathione

1977 • 54 citations

Antibody as immunological probe for studying refolding of bovine serum albumin. Refolding within each domain.

1977 • 54 citations

Regulation of liver phosphorylase phosphatase by glutathione disulfide.

1980 • 51 citations

Insulin's effect on glucose oxidation independent of glucose transport

1976 • 51 citations

Two interconvertible forms of L-type pyruvate kinase from rat liver

1973 • 49 citations

Microsomal mixed-function oxidase-dependent renaturation of reduced ribonuclease

1977 • 49 citations

Glutathione disulfide inactivates, destabilizes, and enhances proteolytic susceptibility of fructose-1,6-bisphosphate aldolase.

1984 • 48 citations

Glutathione Oxidation and Activation of Pentose Phosphate Cycle during Hydroperoxide Metabolism. A Comparison of Livers from Fed and Fasted Rats

1983 • 46 citations

Thiol-disulfide-dependent interconversion of active and latent forms of rat hepatic 3-hydroxy-3-methylglutaryl-coenzyme a reductase

1982 • 45 citations

Resolution of protein disulphide-isomerase and glutathione-insulin transhydrogenase activities by covalent chromatography

1980 • 45 citations

Characterization, kinetics and comparative properties of thiol:protein disulfide oxidoreductase

1978 • 44 citations

Decreased Flux through Pyruvate Dehydrogenase by Thiol Oxidation during t-Butyl Hydroperoxide Metabolism in Perfused Rat Liver

1983 • 44 citations

Insulin degradation. XIII. Kinetic analysis of the mechanism of insulin degradation by gluthathione-insulin transhydrogenase (thiol:protein-disulfide oxidoreductase)

1975 • 43 citations

The inhibition of hexokinase by disulphides

1963 • 42 citations

The identity of the insulin degrading thiol‐protein disulfide oxidoreductase (glutathione—insulin transhydrogenase) with the sulfhydryl‐disulfide interchange enzyme

1973 • 41 citations

Reversible inhibition of adenylate cyclase activity of rat brain caudate nucleus by oxidized glutathione

1978 • 41 citations

Insulin degradation. XIV. Interaction of insulin analogs, glucagon, growth hormone, vasopressin, oxytocin, and scrambled forms of ribonuclease and lysozyme with glutathione-insulin transhydrogenase (thiol:protein-disulfide oxidoreductase). Dependence upon conformation

1975 • 41 citations

Formation of disulfide bonds between glutathione and membrane sh groups in human erythrocytes

1979 • 40 citations

Role of cellular redox state and glutathione in adenylate cyclase activity in rat adipocytes

1979 • 39 citations

Enzyme-Catalysed Disulphide Interchange and Protein Biosynthesis

1977 • 39 citations

Specific mixed disulfide formation with purified bovine cardiac glycogen synthase I and glutathione.

1983 • 37 citations

Rapid stimulation of the hexose monophosphate shunt in the isolated perfused rat heart: Possible involvement of oxidized glutathione

1981 • 35 citations

Analysis of protein-glutathione mixed disulfides by high performance liquid chromatography

1983 • 35 citations

A critical appraisal of the effect of oxidized glutathione on hepatic glucose 6-phosphate dehydrogenase activity

1983 • 34 citations

Xanthine oxidase: An enzyme playing a role in the killing mechanism of polymorphonuclear leucocytes

1980 • 33 citations

Glutathione-dependent Interconversion of Microheterogeneous Forms of Glucose-6-Phosphate Dehydrogenase in Rat Liver

1972 • 32 citations

Isolation and purification of a regulating cofactor of the pentose-phosphate pathway

1979 • 32 citations

Regulation of pyruvate dehydrogenase kinase activity by protein thiol-disulfide exchange.

1982 • 31 citations

Rise of Coenzyme A‐Glutathione Mixed Disulfide during Hydroperoxide Metabolism in Perfused Rat Liver

1982 • 30 citations

Regulatory sulfhydryl groups and activation by homocystine in liver fructose diphosphatase

1970 • 30 citations

Interconversions between different sulfhydryl-related kinetic states in glucokinase

1983 • 30 citations

Activation of liver guanylate cyclase by paraquat: possible role of superoxide anion.

1979 • 29 citations

The role of glutathione in rat adipocyte pentose phosphate cycle activity

1981 • 27 citations

Human erythrocyte glucose 6-phosphate dehydrogenase. Content of bound coenzyme

1974 • 27 citations

Reversible inactivation of tyrosine amino transferase from guinea pig liver by thiol and disulfide compounds

1978 • 27 citations

Nuclear‐Magnetic‐Resonance Studies of Pseudomonas aeruginosa Cytochrome c‐551

1977 • 26 citations

Disulphide Exchange Reactions in the Control of Enzymic Activity

1981 • 26 citations

The reaction of chicken liver fatty acid synthetase with 5,5′-dithiobis(2-nitrobenzoic acid)

1982 • 26 citations

Properties of latent and thiol-activated rat hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase and regulation of enzyme activity

1983 • 25 citations

Protein-Bound Glutathione in Mammalian Lenses and in Galactose Cataract

1976 • 24 citations

The regulation of rat liver xanthine oxidase: Conversion of type D (dehydrogenase) into type O (oxidase) by a thermolabile factor, and reversibility by dithioerythritol

1970 • 24 citations

Effect of paraquat on plasma enzymes, insulin, glucose, and liver glycogen in the rat

1979 • 24 citations

Purification and properties of a new glutathione-dependent thiol:disulphide oxidoreductase from rat liver

1982 • 21 citations

Reversible inactivation of soluble liver guanylate cyclase by disulfides

1981 • 18 citations

Activation of plant acid phosphatases by oxidized glutathione and dehydroascorbate

1979 • 18 citations

Rat liver levels of coenzyme A-glutathione and of enzymes in its metabolism

1972 • 17 citations

Influence of Glutathione on the Reactivation of Enzymes Containing Cysteine or Cystine

1983 • 16 citations

Reductive activation of fructose-1,6-bisphosphatase and the peroxide effect on chloroplast photosynthesis

1983 • 15 citations

Sulfhydryl group involvement in the modulation of guanosine 3′,5′-monophosphate metabolism by nitric oxide, norepinephrine, pyruvate and t-butyl hydroperoxide in minced rat lung

1982 • 15 citations

Rapid and reversible activation of acetyl CoA hydrolase in intact pineal cells by disulfide exchange

1980 • 15 citations

Human erythrocyte glucose 6-phosphate dehydrogenase. Interaction with oxidized and reduced coenzyme

1974 • 15 citations

Early and delayed biochemical effects of paraquat toxicity on rat lung

1980 • 14 citations

Low glucose-6-phosphate dehydrogenase activity and increased sensitivity to paraquat toxicity

1980 • 13 citations

Formation of Interchain Disulfide Bonds in Bence Jones Proteins and Immunoglobulins1

1976 • 12 citations

Protein disulphide isomerase activity in collagen‐synthesising tissues of the chick embryo

1978 • 12 citations

Peroxide induced activation of glycogen phosphorylase a activity in vascular smooth muscle

1982 • 9 citations

The effect of oxygen and paraquat on the 14C-glucose oxidation of rabbit alveolar macrophages and lung slices.

1979 • 4 citations

Pentose Pathway in Pulmonary Fibrosis Due to Chronic Paraquat Poisoning

1980 • 2 citations