Physical Exercise as a Preventive or Disease-Modifying Treatment of Dementia and Brain Aging

Exercise training increases size of hippocampus and improves memory

2011 • 4,105 citations

Physical Activity and Public Health in Older Adults

2007 • 2,990 citations

Running enhances neurogenesis, learning, and long-term potentiation in mice

1999 • 2,829 citations

Practice parameter: Early detection of dementia: Mild cognitive impairment (an evidence-based review) [RETIRED]

2001 • 2,072 citations

Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice

2005 • 2,005 citations

Aerobic Exercise Training Increases Brain Volume in Aging Humans

2006 • 1,991 citations

Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment

2005 • 1,779 citations

Cardiovascular fitness, cortical plasticity, and aging

2004 • 1,612 citations

Aerobic Exercise and Neurocognitive Performance: A Meta-Analytic Review of Randomized Controlled Trials

2010 • 1,566 citations

Effect of Physical Activity on Cognitive Function in Older Adults at Risk for Alzheimer Disease

2008 • 1,529 citations

Physical Activity and Risk of Cognitive Impairment and Dementia in Elderly Persons

2001 • 1,518 citations

Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition

2004 • 1,345 citations

An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus

2007 • 1,288 citations

Transport of brain-derived neurotrophic factor across the blood–brain barrier

1998 • 1,258 citations

The effects of exercise training on elderly persons with cognitive impairment and dementia: A meta-analysis11No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the author(s) or upon any organization with which the author(s) is/are associated.

2004 • 1,206 citations

Effects of Aerobic Exercise on Mild Cognitive Impairment

2010 • 1,066 citations

Aerobic Fitness Reduces Brain Tissue Loss in Aging Humans

2003 • 994 citations

Circulating Insulin-Like Growth Factor I Mediates Exercise-Induced Increases in the Number of New Neurons in the Adult Hippocampus

2001 • 976 citations

Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain

1996 • 943 citations

Aerobic fitness is associated with hippocampal volume in elderly humans

2009 • 940 citations

Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence

2008 • 890 citations

BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

1991 • 887 citations

Brain-derived neurotrophic factor in the control human brain, and in Alzheimer’s disease and Parkinson’s disease

2001 • 851 citations

Evidence for a release of brain‐derived neurotrophic factor from the brain during exercise

2009 • 834 citations

Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male sprague–dawley rats in vivo

2004 • 816 citations

VEGF is necessary for exercise‐induced adult hippocampal neurogenesis

2003 • 801 citations

Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease

2005 • 769 citations

The Effect of Acute Exercise on Serum Brain-Derived Neurotrophic Factor Levels and Cognitive Function

2007 • 769 citations

Plasticity of brain networks in a randomized intervention trial of exercise training in older adults

2010 • 767 citations

Exercise Plus Behavioral Management in Patients With Alzheimer Disease

2003 • 758 citations

Circulating Insulin-Like Growth Factor I Mediates Effects of Exercise on the Brain

2000 • 734 citations

The Impact of Resistance Exercise on the Cognitive Function of the Elderly

2007 • 705 citations

Resistance Training and Executive Functions

2010 • 676 citations

Prevalence of mild cognitive impairment is higher in men

2010 • 660 citations

Systematic Review: Factors Associated With Risk for and Possible Prevention of Cognitive Decline in Later Life

2010 • 655 citations

Precursor form of brain‐derived neurotrophic factor and mature brain‐derived neurotrophic factor are decreased in the pre‐clinical stages of Alzheimer's disease

2005 • 649 citations

Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF

1996 • 583 citations

Review: Mortality trends in the general population: the importance of cardiorespiratory fitness

2010 • 560 citations

Brain-derived neurotrophic factor is reduced in Alzheimer's disease

1997 • 551 citations

Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function

2006 • 516 citations

Physical activity and memory functions: An interventional study

2009 • 477 citations

Physical activity predicts gray matter volume in late adulthood

2010 • 472 citations

Incidence and Prediction of Falls in Dementia: A Prospective Study in Older People

2009 • 460 citations

Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus

2005 • 455 citations

Voluntary exercise alters the cytoarchitecture of the adult dentate gyrus by increasing cellular proliferation, dendritic complexity, and spine density

2005 • 453 citations

Endurance training enhances BDNF release from the human brain

2009 • 451 citations

The aging brain: morphomolecular senescence of cortical circuits

2004 • 414 citations

Exercise and time-dependent benefits to learning and memory

2010 • 364 citations

Cardiorespiratory fitness and brain atrophy in early Alzheimer disease

2008 • 363 citations

Physical Exercise, Aging, and Mild Cognitive Impairment

2010 • 356 citations

Brain‐derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition

2008 • 354 citations

Acute BDNF and cortisol response to low intensity exercise and following ramp incremental exercise to exhaustion in humans

2006 • 346 citations

BDNF is a novel marker of cognitive function in ageing women: The DR’s EXTRA Study

2008 • 328 citations

Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease

2000 • 316 citations

Exercise and Alzheimer's disease biomarkers in cognitively normal older adults

2010 • 311 citations

Physical Activity Over the Life Course and Its Association with Cognitive Performance and Impairment in Old Age

2010 • 307 citations

Endurance training increases plasma brain-derived neurotrophic factor concentration in young healthy men.

2008 • 306 citations

Basal serum levels and reactivity of nerve growth factor and brain-derived neurotrophic factor to standardized acute exercise in multiple sclerosis and controls

2003 • 296 citations

Depressive Symptom Outcomes of Physical Activity Interventions: Meta-analysis Findings

2010 • 288 citations

Exercise exerts neuroprotective effects on Parkinson's disease model of rats

2009 • 287 citations

Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging

2004 • 285 citations

Cognitive and Physical Activity Differently Modulate Disease Progression in the Amyloid Precursor Protein (APP)-23 Model of Alzheimer’s Disease

2006 • 283 citations

Acute effect of brief low- and high-intensity exercise on circulating insulin-like growth factor (IGF) I, II, and IGF-binding protein-3 and its proteolysis in young healthy men.

1996 • 264 citations

The effects of forced exercise on hippocampal plasticity in the rat: A comparison of LTP, spatial- and non-spatial learning

2006 • 264 citations

Walking or vitamin B for cognition in older adults with mild cognitive impairment? A randomised controlled trial

2008 • 261 citations

BDNF serum and CSF concentrations in Alzheimer’s disease, normal pressure hydrocephalus and healthy controls

2006 • 254 citations

Functional connectivity: A source of variance in the association between cardiorespiratory fitness and cognition?

2010 • 247 citations

Neuroprotective effects of prior limb use in 6‐hydroxydopamine‐treated rats: possible role of GDNF

2003 • 246 citations

Influence of exercise on serum brain-derived neurotrophic factor concentrations in healthy human subjects

2007 • 243 citations

Exercise differentially regulates synaptic proteins associated to the function of BDNF

2006 • 242 citations

Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease

2009 • 240 citations

Neuroanatomical correlates of aging, cardiopulmonary fitness level, and education

2008 • 237 citations

Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls

2008 • 233 citations

Essentials of the Proper Diagnoses of Mild Cognitive Impairment, Dementia, and Major Subtypes of Dementia

2003 • 233 citations

Exercise-induced changes in dendritic structure and complexity in the adult hippocampal dentate gyrus

2005 • 231 citations

Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid

2008 • 224 citations

Effects of resistance training on insulin-like growth factor-I and IGF binding proteins

2001 • 223 citations

Cardiorespiratory Fitness and Preserved Medial Temporal Lobe Volume in Alzheimer Disease

2009 • 209 citations

Age effects on the regulation of adult hippocampal neurogenesis by physical activity and environmental enrichment in the APP23 mouse model of Alzheimer disease

2009 • 198 citations

Treadmill exercise represses neuronal cell death in an aged transgenic mouse model of Alzheimer's disease

2010 • 195 citations

Exercise induces BDNF and synapsin I to specific hippocampal subfields

2004 • 193 citations

Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway

2010 • 192 citations

The timecourse of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise

2004 • 192 citations

Exercise training acts as a therapeutic strategy for reduction of the pathogenic phenotypes for Alzheimer's disease in an NSE/APPsw-transgenic model

1998 • 191 citations

Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition

2008 • 188 citations

Training augments resistance exercise induced elevation of circulating brain derived neurotrophic factor (BDNF)

2010 • 187 citations

Effects of aerobic exercise training on cognitive function and cortical vascularity in monkeys

2010 • 185 citations

Effects of Physical Activity on Cognitive Functioning in Middle Age: Evidence From the Whitehall II Prospective Cohort Study

2005 • 181 citations

The effects of resistance training on well-being and memory in elderly volunteers

1998 • 170 citations

Serum BDNF, TNF-α and IL-1β levels in dementia patients

2006 • 168 citations

Diet, Exercise and the Metabolic Syndrome

2006 • 162 citations

Higher BDNF serum levels predict slower cognitive decline in Alzheimer's disease patients

2010 • 157 citations

Life span and synapses: will there be a primary senile dementia?

2001 • 155 citations

Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology

2011 • 150 citations

Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice

2008 • 148 citations

Strength training does not influence serum brain-derived neurotrophic factor

2010 • 141 citations

Effect of Regular Exercise on Senile Dementia Patients

2008 • 135 citations

Serum brain-derived neurotrophic factor response to aerobic exercise in multiple sclerosis

2008 • 132 citations

Cardio-respiratory fitness, habitual physical activity and serum brain derived neurotrophic factor (BDNF) in men and women

2008 • 130 citations

Effects of Strength and Endurance Training on Brain-derived Neurotrophic Factor and Insulin-like Growth Factor 1 in Humans

2008 • 126 citations

Exercise‐induced changes in insulin‐like growth factors and their low molecular weight binding protein in healthy subjects and patients with growth hormone deficiency

1990 • 125 citations

Physical activity elicits sustained activation of the cyclic AMP response element-binding protein and mitogen-activated protein kinase in the rat hippocampus

2001 • 121 citations

Vascular Risk Factors: Imaging and Neuropathologic Correlates

2010 • 119 citations

Effect of Resistance Exercise on Serum Levels of Growth Factors in Humans

2010 • 116 citations

Physical Inactivity and Mortality Risk

2011 • 106 citations

Exercise protects against MPTP-induced neurotoxicity in mice

2010 • 104 citations

Decreased serum brain-derived neurotrophic factor in trained men

2008 • 100 citations

Wheel-running in a transgenic mouse model of Alzheimer's disease: Protection or symptom?

2008 • 99 citations

The relation between insulin-like growth factor I levels and cognition in healthy elderly: A meta-analysis

2005 • 99 citations

Physical Activity and Alzheimer Disease Course

2010 • 98 citations

Repression of tau hyperphosphorylation by chronic endurance exercise in aged transgenic mouse model of tauopathies

2009 • 98 citations

Sarcopenia

2010 • 85 citations

Lack of exercise, via hindlimb suspension, impedes endogenous neurogenesis

2007 • 84 citations

Management of osteoporosis in the elderly

2009 • 77 citations

Exercise and cognition: Results from the National Long Term Care Survey

2010 • 74 citations

Relationships between cortisol, dehydroepiandrosterone sulphate and insulin-like growth factor-I system in dementia

2001 • 73 citations

Acute strength exercise and the involvement of small or large muscle mass on plasma brain-derived neurotrophic factor levels

2010 • 73 citations

Effects of Resistance Training on Insulin‐Like Growth Factor and its Binding Proteins in Men and Women Aged 60 to 85

2002 • 55 citations

Voluntary exercise does not enhance long-term potentiation in the adolescent female dentate gyrus

2011 • 47 citations

Brain derived neurotrophic factor, cardiopulmonary fitness and cognition in patients with coronary artery disease

2011 • 45 citations

Exercise and Atherogenesis

2001 • 40 citations

Effects of endurance exercise on ventral tegmental area neurons in the chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and probenecid-treated mice

2008 • 38 citations

IGF‐I and IGFBP-3 during Continuous and Interval Exercise

2008 • 32 citations

No Effect of Exercise on Insulin-Like Growth Factor-I, Insulin, and Glucose in Young Women Participating in a 16-Week Randomized Controlled Trial

2010 • 31 citations

Brief, high intensity exercise alters serum ghrelin and growth hormone concentrations but not IGF-I, IGF-II or IGF-I bioactivity

2010 • 31 citations

Mouse Models of Alzheimer’s Dementia: Current Concepts and New Trends

2008 • 27 citations

Review: exercise programmes reduce anxiety symptoms in sedentary patients with chronic illnesses

2010 • 2 citations